35 results about "Dermatophyton" patented technology

The invention belongs to the field of natural medicine and cosmetics, and provides application of Chinese torreya essential oil to preparation of anti-dermatophytes medicine, or application of Chinese torreya essential oil as efficiency ingredients in cosmetics for inhibiting the dermatophytes. In-vitro antibacterial activity study on the Chinese torreya essential oil shows that the Chinese torreya essential oil has better antibacterial activity on common pathogenic dermatophytes capable of causing tinea capitis, tinea corporis and little onychomycosis. The Chinese torreya essential oil is essential oil prepared from Chinese torreya aril by a distillation method, a cold squeezing method, a solvent extracting method or a carbon dioxide supercritical extraction method and the like. The Chinese torreya essential oil has the quality requirements that the Chinese torreya essential oil is colourless to yellowish Green liquid, and has the characteristic flavor of Chinese torreya fruit; the relative density (20 DEG C / 20 DEG C) is 0.850 to 0.860; the content sum of characteristic components of Alpha-pinene and limonene is greater than or equal to 30 percent. The invention discloses a new purpose of the Chinese torreya essential oil to prepare anti-dermatophytes medicine or cosmetics. In addition, an optimized preparation method of the Chinese torreya essential oil is provided by comparing the advantages and disadvantages of different extraction methods of the Chinese torreya essential oil.

The invention relates to methods assessing nucleic acids encoding a dermatophyte extracellular serine / threonine-rich protein (ESTRP gene) in identifying and preferably differentiating between dermatophytes. The invention relates further to corresponding detection kits, in addition to isolated probes and oligonucleotides.

The present invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungus. More particularly, the present invention relates to the synergistic enhancement of activity of a combination by menthyl acetate or Geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations.

The invention discloses a compound clobetasol propionate nano-medicament of which the particle size is 1-100 nanometers. The medicament consists of the following components in percentage by weight: 10.0-50 percent of surfactant, 0-8 percent of cosurfactant, 0.5-20 percent of oil, 0.001-4.0 percent of amitraz, 0.001-4.0 percent of clobetasol propionate, 0.001-10 percent of terbinafine and the balance of distilled water, wherein the total percentage by weight of the components is 100 percent. The medicament has the effects of resisting bacteria, diminishing inflammation, relieving itching and pain, killing mites and treating fungal diseases, eczema and various types of dermatitis caused by fungi such as dermatophyte, microsporosis capitis, acrothesium floccosum, microzyme of monilia and chaff ringworm fungus, and the like. The medicament is a yellow or colorless clear transparent liquid and has the advantages of high stability, high wetting property, good transdermal effect, nontoxicity, non-irritation, high safety, easiness for preparing, low cost and convenience for popularizing.

Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.

The invention discloses an application of sophorolipids in preparing drugs for resisting dermatophyte, and an application of a combination where the sophorolipids is used as an effective component inpreparing drugs for resisting dermatophyte. With low price, little dosage and remarkable antibacterial effect, the invention has no side effect on the human, and in certain aspects can be used as a drug for replacing conventional antifungal drugs which produce heat resistance easily and drugs for treating skin tinea disease such as corticosteroid with severe side effects. Thus, the invention has great application prospect.

The present invention concerns novel compounds of Formula (I):wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

The invention discloses a jiumiao jiaxianling traditional Chinese medicine composition which is prepared from the following components in parts by weight: 1-30 parts of golden larch bark, 1-30 parts of common goldenrod, 1-30 parts of fructus cnidii, 1-30 parts of dragon blood, 1-30 parts of rheum officinale, 1-30 parts of golden cypress, 1-15 parts of indigo naturalis, 1-15 parts of dried alum and medical oil, including 0.1g-3 parts of artemisia scoparia oil, 0.1g-3 parts of clove oil, 0.1g-3 parts of zanthoxylum oil and 0.1g-3 parts of artemisia oil. The traditional Chinese medicine composition has the killing effect on dermatophytes, trichophyton rubrum, trichophyton gypseum, epidermophyton floccosum, alpha fungus, molds, saccharomycetes and the like and has the advantages that a patient feel less pain, the effect is good, the disease is not easy to relapse, the bacteria can be thoroughly killed, and the small toxic or side effect is caused.

The invention discloses an extract of Artemisia argyi, a preparation method thereof, and application of an antibacterial agent for dermatophytes, belonging to the technical application field of plant-derived antibacterial preparations. The antibacterial agent is the wormwood leaf extract obtained by ultrasonic extraction (5-75% ethanol) or ethanol reflux extraction with Chinese herbal medicine argyi leaf as raw material. Dermatophytes are highly inhibited. After being separated and purified by macroporous adsorption resin, the 40-95% ethanol fractions have different degrees of inhibitory activity against dermatophytes, and the 95% ethanol fraction is the most significant. At the same time, the main chemical compositions of the 95% ethanol separated fractions are iszelanin, emodin methyl ether, vitexin, and brown cyanidin. The invention can effectively inhibit dermatophytes, has the advantages of safety, high efficiency and low toxicity and side effects, and provides a new drug source for the prevention and treatment of dermatophytes such as hand and tinea pedis.

The invention relates to the application of Caragana caragana extract in the preparation of medicines for the treatment and prevention of skin ringworm. The extract obtained by adopting conventional supercritical fluid extraction method in the plant seeds of several species contains at least the Caragana caragana extract in various dosage forms of medicines for treating and preventing skin ringworm. The Caragana caragana extract in the present invention is an active ingredient that can significantly inhibit three common dermatophytes of Microsporum canis, Trichophyton mentagrophytes and Trichophyton rubrum.