Compound clobetasol propionate nano-medicament and preparation method thereof
A technology of clobetasol propionate and compound chlorine propionate, which is applied in the field of medicine, can solve the problems of unsatisfactory transdermal absorption effect, unsatisfactory clinical effect, large drug smell, etc., and achieves low toxicity, good wettability, and surface low tension effect
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Embodiment 1
[0066] 1) Add 0.013g of clobetasol propionate into a mixture of 0.1g of 1,2-propanediol and 0.1g of absolute ethanol, and stir well;
[0067] 2) Add 0.01g amitraz, 0.26g terbinafine to 9.2g Tween-80 surfactant and stir until completely dissolved, then add 0.69g IPM, 0.005g almond oil and 0.005g wheat germ oil to the mixture, stir Evenly as the oil phase;
[0068] 3) Add the solution prepared in step 1) into the oil phase prepared in step 2), and stir evenly;
[0069] 4) Stir the solution prepared in step 3) rapidly at room temperature, and slowly add 15 g of distilled water dropwise while stirring until the system becomes a transparent and clear liquid.
Embodiment 2
[0071] Clobetasol Propionate 0.02g Amitraz 0.016g
[0072] Terbinafine 0.3g RH-40 8g
[0073] IPM 0.84g Glycerin 0.2g
[0074] Distilled water 15.81g Isopropyl laurate 0.96g
Embodiment 3
[0076] Clobetasol Propionate 0.013g Amitraz 0.013g
[0077] Terbinafine 0.26g Tween-20 8.4g
[0078] Glyceryl triacetate 0.5g Soybean oil 0.5g
[0079] Olive oil 0.5g Absolute ethanol 0.1g
[0080] Distilled water 17.34g
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