Use of crataegus pit extract in preparation of medicine for treating mycosis
A technology of hawthorn core and extract, which is applied to the preparation of drugs for treating antifungal diseases. The hawthorn core extract can solve the problem of coking at the bottom of the pot in the field of preparation of antifungal disease drugs, hawthorn core extract or its medicinal composition , to achieve the effect of low cost, simple manufacturing process and safe use
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experiment example 1
[0030] Experimental example 1. Observation of antifungal effect of hawthorn core extract in vitro
[0031] METHODS: The MIC of hawthorn kernel extracts against various fungi was determined by double plate dilution method, and fluconazole and amphotericin were used as controls.
[0032] Results: MIC of amphotericin and fluconazole against Candida albicans 90 Both are 64μg / ml, the MIC to Candida tropicalis, Trichophyton rubrum, Trichophyton mentagrophytes 90 Both were 128 μg / ml. The MIC of test drug stock solution, heavy stock solution, and purified solution against 66 strains of Candida albicans, 13 strains of Candida tropicalis, and 9 strains of Trichophyton mentagrophytes 90 Are respectively 1.25% (V / V), 1.25% (V / V), 2.5% (V / V), the MIC of 25 strains of Trichophyton rubrum 90 They are 0.62% (V / V), 1.25% (V / V), and 1.25% (V / V), respectively. 8-16μg / ml of amphotericin and fluconazole can kill 7374 strains of Candida albicans and 6180 strains of Trichophyton rubrum after 60 ...
experiment example 2
[0119] Experimental example 2 The effect of hawthorn core extract on inhibiting other fungi in vitro
[0120] Referring to the experimental method of Experimental Example 1, the effects of 2 hawthorn core extracts on inhibiting other fungi in vitro were tested.
[0121] Table 3 summarizes the effect of hawthorn core distillate crude oil on inhibiting other fungi in vitro. The preparation method of the stock solution is to put the hawthorn core into a dry distillation container after washing and draining, heat to 180--240°C for dry distillation, and condense the steam to collect the liquid; the collected liquid is precipitated and then the upper layer oil is collected as the hawthorn core distillate oil stock solution ; or the collected liquid is placed in an evaporating dish, placed in a water bath, the temperature of the water bath is maintained between 80-100 ° C, and heated for half an hour to remove the volatile substances and moisture in the distillate. The black shiny o...
experiment example 3
[0193] Therapeutic Effect of Experimental Example 3 Hawthorn Core Extract
[0194] Treat each 30 cases of clinical effects of fungal infection diseases with 15% hawthorn kernel distillate oil purification liquid (preparation method is the same as experimental example 1):
[0195] Effect
[0196] Disease type Effective rate
[0197] Ineffective Significantly effective Effective cure
[0198] Hand and athlete's foot 0 3 9 18 100%
[0199] Onychomycosis 0 7 15 8 100%
[0200] Tinea capitis 3 9 16 2 88.89%
[0201] Ringworm 2 11 7 10 92.86%
[0202] Bacterial vaginosis 1 8 10 11 96.55%
[0203] Total 6 38 57 42 95.66%
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