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Use of crataegus pit extract in preparation of medicine for treating mycosis

A technology of hawthorn core and extract, which is applied to the preparation of drugs for treating antifungal diseases. The hawthorn core extract can solve the problem of coking at the bottom of the pot in the field of preparation of antifungal disease drugs, hawthorn core extract or its medicinal composition , to achieve the effect of low cost, simple manufacturing process and safe use

Inactive Publication Date: 2004-06-09
铁毅 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, if you start to heat up too quickly, it is easy to burn at the bottom of the pot

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0030] Experimental example 1. Observation of antifungal effect of hawthorn core extract in vitro

[0031] METHODS: The MIC of hawthorn kernel extracts against various fungi was determined by double plate dilution method, and fluconazole and amphotericin were used as controls.

[0032] Results: MIC of amphotericin and fluconazole against Candida albicans 90 Both are 64μg / ml, the MIC to Candida tropicalis, Trichophyton rubrum, Trichophyton mentagrophytes 90 Both were 128 μg / ml. The MIC of test drug stock solution, heavy stock solution, and purified solution against 66 strains of Candida albicans, 13 strains of Candida tropicalis, and 9 strains of Trichophyton mentagrophytes 90 Are respectively 1.25% (V / V), 1.25% (V / V), 2.5% (V / V), the MIC of 25 strains of Trichophyton rubrum 90 They are 0.62% (V / V), 1.25% (V / V), and 1.25% (V / V), respectively. 8-16μg / ml of amphotericin and fluconazole can kill 7374 strains of Candida albicans and 6180 strains of Trichophyton rubrum after 60 ...

experiment example 2

[0119] Experimental example 2 The effect of hawthorn core extract on inhibiting other fungi in vitro

[0120] Referring to the experimental method of Experimental Example 1, the effects of 2 hawthorn core extracts on inhibiting other fungi in vitro were tested.

[0121] Table 3 summarizes the effect of hawthorn core distillate crude oil on inhibiting other fungi in vitro. The preparation method of the stock solution is to put the hawthorn core into a dry distillation container after washing and draining, heat to 180--240°C for dry distillation, and condense the steam to collect the liquid; the collected liquid is precipitated and then the upper layer oil is collected as the hawthorn core distillate oil stock solution ; or the collected liquid is placed in an evaporating dish, placed in a water bath, the temperature of the water bath is maintained between 80-100 ° C, and heated for half an hour to remove the volatile substances and moisture in the distillate. The black shiny o...

experiment example 3

[0193] Therapeutic Effect of Experimental Example 3 Hawthorn Core Extract

[0194] Treat each 30 cases of clinical effects of fungal infection diseases with 15% hawthorn kernel distillate oil purification liquid (preparation method is the same as experimental example 1):

[0195] Effect

[0196] Disease type Effective rate

[0197] Ineffective Significantly effective Effective cure

[0198] Hand and athlete's foot 0 3 9 18 100%

[0199] Onychomycosis 0 7 15 8 100%

[0200] Tinea capitis 3 9 16 2 88.89%

[0201] Ringworm 2 11 7 10 92.86%

[0202] Bacterial vaginosis 1 8 10 11 96.55%

[0203] Total 6 38 57 42 95.66%

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Abstract

The present invention discloses crataegus pit extract or its medicinal composition and its application in preparation of medicine for curing or preventing mycetes, specially for resisting dermatomycosis and candidiosis. Said invention uses the crataegus pit as raw material, and adopts the existent technological process including the steps of pyrogenic distillation, purification and others to obtain the crataegus pit distillate oil raw liquor. Said medicine has no any toxic side effects, and its therapeutic effect is obvious.

Description

technical field [0001] The present invention relates to the use of hawthorn core extract in the preparation of medicines for treating antifungal diseases, in particular to the use of hawthorn core extract or its pharmaceutical composition in the preparation of medicines for treating antifungal diseases, which belongs to the field of medicines. Background technique [0002] Hawthorn core extract is a black viscous liquid obtained by dry distillation of hawthorn fruit core. It has antibacterial effect and can be used for sterilization and air purification. [0003] Because the black viscous liquid obtained by dry distillation of hawthorn fruit contains oil, jelly and water, it needs to be concentrated and refined as a medicinal or food raw material. [0004] The preparation methods of many hawthorn core extracts are disclosed in the prior art, mainly including: [0005] Chinese patent application No. 85100470 discloses a method of using hawthorn core as raw material, dry dist...

Claims

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Application Information

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IPC IPC(8): A61P31/10
Inventor 铁毅刘民俐
Owner 铁毅
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