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Compound clobetasol propionate nano-medicament and preparation method thereof

A technology of clobetasol propionate and compound chlorine propionate, which is applied in the field of medicine, can solve problems such as unsatisfactory transdermal absorption effect, unsatisfactory clinical effect, and strong drug odor, and achieve low toxicity, good wettability, and surface low tension effect

Inactive Publication Date: 2012-01-25
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented compound describes an ester derivative called CLOBEX® (Cloprostenil) that has several advantages over other drugs such as flumazenil or clonidone due to its small size (10-10m). It also shows better stability during storage at room temperature compared with others but it still requires specific conditions like pH value adjustment before use because they are sensitive to changes from external factors like sunlight exposure.

Problems solved by technology

This patented technical problem addressed in this patents relates to developing an effective therapy for veterinary medicine due to various factors such as poor patient compliance during administration of new products like creams containing terbafefuran, which may cause harmful symptoms associated therewith when administered over longer periods.

Method used

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  • Compound clobetasol propionate nano-medicament and preparation method thereof
  • Compound clobetasol propionate nano-medicament and preparation method thereof
  • Compound clobetasol propionate nano-medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] 1) Add 0.013g of clobetasol propionate into a mixture of 0.1g of 1,2-propanediol and 0.1g of absolute ethanol, and stir well;

[0067] 2) Add 0.01g amitraz, 0.26g terbinafine to 9.2g Tween-80 surfactant and stir until completely dissolved, then add 0.69g IPM, 0.005g almond oil and 0.005g wheat germ oil to the mixture, stir Evenly as the oil phase;

[0068] 3) Add the solution prepared in step 1) into the oil phase prepared in step 2), and stir evenly;

[0069] 4) Stir the solution prepared in step 3) rapidly at room temperature, and slowly add 15 g of distilled water dropwise while stirring until the system becomes a transparent and clear liquid.

Embodiment 2

[0071] Clobetasol Propionate 0.02g Amitraz 0.016g

[0072] Terbinafine 0.3g RH-40 8g

[0073] IPM 0.84g Glycerin 0.2g

[0074] Distilled water 15.81g Isopropyl laurate 0.96g

Embodiment 3

[0076] Clobetasol Propionate 0.013g Amitraz 0.013g

[0077] Terbinafine 0.26g Tween-20 8.4g

[0078] Glyceryl triacetate 0.5g Soybean oil 0.5g

[0079] Olive oil 0.5g Absolute ethanol 0.1g

[0080] Distilled water 17.34g

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Abstract

The invention discloses a compound clobetasol propionate nano-medicament of which the particle size is 1-100 nanometers. The medicament consists of the following components in percentage by weight: 10.0-50 percent of surfactant, 0-8 percent of cosurfactant, 0.5-20 percent of oil, 0.001-4.0 percent of amitraz, 0.001-4.0 percent of clobetasol propionate, 0.001-10 percent of terbinafine and the balance of distilled water, wherein the total percentage by weight of the components is 100 percent. The medicament has the effects of resisting bacteria, diminishing inflammation, relieving itching and pain, killing mites and treating fungal diseases, eczema and various types of dermatitis caused by fungi such as dermatophyte, microsporosis capitis, acrothesium floccosum, microzyme of monilia and chaff ringworm fungus, and the like. The medicament is a yellow or colorless clear transparent liquid and has the advantages of high stability, high wetting property, good transdermal effect, nontoxicity, non-irritation, high safety, easiness for preparing, low cost and convenience for popularizing.

Description

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Claims

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Application Information

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Owner NORTHWEST A & F UNIV
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