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Application of polyphyllin in preparation of anti-candida albicans fluconazole drug-resistant strain product and anti-dermatophyte product

A technology of Chonglou saponin and dermatophyte is applied in the application field of preparing anti-Candida albicans fluconazole-resistant strain products and anti-dermatophyte products, and can solve problems such as unclear effects and the like

Pending Publication Date: 2022-05-06
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chonglou decoction has different inhibitory effects on Candida albicans, Staphylococcus aureus, hemolytic streptococcus, meningococcus, Shigella, typhoid bacillus, paratyphoid bacillus, Escherichia coli and Pseudomonas aeruginosa. The effect of lausaponin against fluconazole-resistant strains of Candida albicans, Epidermophyton flocculus, Microsporum gypsumoides and Trichophyton rubrum has not been clarified

Method used

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  • Application of polyphyllin in preparation of anti-candida albicans fluconazole drug-resistant strain product and anti-dermatophyte product
  • Application of polyphyllin in preparation of anti-candida albicans fluconazole drug-resistant strain product and anti-dermatophyte product
  • Application of polyphyllin in preparation of anti-candida albicans fluconazole drug-resistant strain product and anti-dermatophyte product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Polyphyll saponin monomer I, II, III, V, VI, VII, H, diosgenin-3-O-α-L-rhamnopyranose-(1→2)-[β-D-pyranose Inhibitory effects of glucose-(1→6)]-β-D-glucopyranoside and total saponins of S. albicans against fluconazole-resistant strains of Candida albicans.

[0036] 1. Strain: Candida albicans fluconazole-resistant strain (provided by the Department of Dermatology, The First Affiliated Hospital of Kunming Medical College)

[0037] 2. Experimental methods and materials

[0038] Materials: papaya saponins I, II, III, V, VI, VII, H, diosgenin-3-O-α-L-rhamnopyranose-(1→2)-[β-D-pyranose Glucose-(1→6)]-β-D-glucopyranoside, a total of eight monomer components, and total saponins of Pauline Polyphylla (purchased from Chengdu Zhibiao Pure Biotechnology Co., Ltd., Chengdu Master Biotechnology Co., Ltd. or obtained by separation in this laboratory), the relevant information is as follows:

[0039] Papaya saponin I: CAS number: 50773-41-6; Molecular formula: C 44 h 70 o 16 ;Mol...

Embodiment 2

[0058] Diosgenin monomer I, II, V, VI, VII, H, diosgenin, diosgenin-3-O-α-L-rhamnopyranose-(1→2)-[β-D- Glucopyranose-(1→6)]-β-D-glucopyranoside, pinosaponin-3-O-α-L-arabinofuranosyl-(1→4)-β-D-glucopyranose The effects of diosgenin, diosgenin-3-O-α-L-arabinofuranoside-(1→4)-β-D-glucopyranoside and total saponins of pachyrhiza on Epidermophyton flocculus, Microsporum gypsum and Inhibition of Trichophyton rubrum.

[0059] 1. Strains: Epidermophyton floccosum CBS 566.94, Microsporum gypseum CBS118893, Trichophyton rubrum ATCC4438 were purchased from the Medical Fungi Collection Center, Chinese Academy of Medical Sciences.

[0060] 2. Experimental methods and materials

[0061]Materials: papaya saponins I, II, V, VI, VII, H, diosgenin, diosgenin-3-O-α-L-rhamnopyranose-(1→2)-[β-D- Glucopyranose-(1→6)]-β-D-glucopyranoside, pinosaponin-3-O-α-L-arabinofuranosyl-(1→4)-β-D-glucopyranose glycosides, diosgenin-3-O-α-L-arabinofuranoside-(1→4)-β-D-glucopyranoside, a total of eight monome...

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Abstract

The invention relates to the technical field of microbial antibiosis, and provides application of polyphyllin in preparation of a product for resisting a candida albicans fluconazole drug-resistant strain and a product for resisting dermatophyte. The polyphyllin has a definite inhibition effect on a candida albicans fluconazole drug-resistant strain, epidermophyton flocculent, microsporum gypsum and trichophyton rubrum, is steroidal saponin, and is greatly different from the currently common azole antifungal drugs such as ketoconazole, fluconazole, itraconazole and the like in structure. The mechanism of the polyphyllin for resisting a candida albicans fluconazole-resistant strain, epidermophyton flocculent, microsporum gypsum or trichophyton rubrum is different from that of azole antifungal drugs, and the polyphyllin is added into the antibacterial product, so that the common antifungal drug-resistant bacteria can be inhibited, the drug resistance and irritation of the preparation are reduced, and the safety of the preparation is improved.

Description

technical field [0001] The invention relates to the field of microbial antibacterial technology, in particular to the application of papaya saponins in the preparation of anti-candida albicans fluconazole-resistant strain products and anti-dermatophyte products. Background technique [0002] Candida is the most common class of opportunistic pathogens, and Candida albicans is one of the main pathogens. As a routine drug for the treatment of Candida, fluconazole is still the first-line drug for clinicians to treat Candida infection. However, with the routine use of the drug, fluconazole-resistant Candida albicans is also increasing. Epidermophyton flocculus can infect humans. The host can be humans, wild animals or pets, but it prefers humans. It can infect the skin and nails, thereby causing tinea pedis, tinea corporis, jock itch or onychomycosis. It can be passed through Contact infection. Microsporum gypsumoid is one of the pathogens of zoonotic superficial mycoses, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P31/10A61P17/00
CPCA61P31/10A61P17/00A61K31/7048A61K36/896A61K2236/333A61K2236/39A61K2236/51Y02A50/30
Inventor 黎胜红刘燕陈月桂白雪刘艳春
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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