162 results about "Control subjects" patented technology

The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides the necessary information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through one or more metabolic pathways of interest. By this method, a comparison between subjects and control subjects reveals the effects of the chemical entity or entities on the biomarkers. This, in turn, allows for the identification of potential therapeutic uses or toxicities of the compound. Combinations of compounds can also be systematically evaluated for complementary, synergistic, or antagonistic actions on the metabolic pathways of interest, using the methods of the present invention as a strategy for identifying and confirming novel therapeutic or toxic combinations of compounds.

A heat exchanger for use in controlling subject's body temperature during a medical procedure comprises a flexible garment adapted for enveloping portions of the subject's body surface with dedicated sections for enveloping different body parts. Defined within the garment is a continuous, fluid tight space, wherein a flow path for heat-control fluid is defined between fluid inlet and fluid outlet. The inner faces of the garment's internal and external layers are made of a heat-weldable material and are point-welded to one another at a plurality of locations throughout the garment with a distance between two adjacent points being between about 8 to about 20 mm.

A method of classifying a test subject comprises collecting imaging data for a plurality of training subjects, control subjects and a test subject. An intensity volume of interest (VOI) and a spatial VOI are selected from said imaging data. Training intensity data and spatial data are calculated for the intensity and spatial VOI. A statistical model can then be created based on the training intensity data and training spatial data to provide a universe of subjects. Control intensity data and spatial data are also calculated for the intensity and spatial VOI. A classifier can then be built dividing the universe into at least two regions. The test subject data can then be applied to the classifier to provide a determination of whether said test subject falls within the first region or the second region. The condition can be a neurological disease state such as temporal lobe epilepsy or Alzheimer's dementia.

When the camera is performing the pan or tilt operation on performing image blurring correction, the image blurring correction is stopped and a vibration-proof lens is returned to a reference position at a speed that is changed according to a focal length of the zoom lens and is reduced if the zoom lens is set on a wide-side in particular so as to prevent a sense of discomfort due to swingback on the pan or tilt operation. The vibration-proof lens may be kept at a fixed position for a fixed time and returned to the reference position after the fixed time elapses so as to alleviate disorder of an image. The control subject for correcting the image blurring may be returned to the reference position by a predetermined function of which variable is time so as to exert control after stopping the image blurring correction on the pan or tilt operation suitably as intended.

A heat exchanger for use in controlling subject's body temperature during a medical procedure comprises a flexible garment adapted for enveloping portions of the subject's body surface with dedicated sections for enveloping different body parts. Defined within the garment is a continuous, fluid tight space, wherein a flow path for heat-control fluid is defined between fluid inlet and fluid outlet. The inner faces of the garment's internal and external layers are made of a heat-weldable material and are point-welded to one another at a plurality of locations throughout the garment with a distance between two adjacent points being between about 8 to about 20 mm.

Methods for the determination of cognitive processing of an individual or groups of individuals are described. Deviation from a control range of cognitive processing is determined with reference to a standardized task. Methods comprise measurement of time to complete the standardized task in a group of control subjects, measurement of temporal eyeblink occurrence during performance of the task by the control subjects, and calculation of a control range for the control subjects, the control range being calculated from at least the temporal eyeblink occurrence during a common phase within the standardized task for the control subject. Deviation from the control range indicates the test subject has altered cognitive processing relative to the control subjects.

A control system includes a basic control command operating unit, a fuel data storage unit, a running results database for storing past running results values of a control subject, a data creating unit configured to calculate a distance between data of the past running results values and the data sets and determining data set in which a distance between data becomes minimum, a modeling unit configured to model a relationship between operation parameters of a combustion apparatus and components in combustion gas of the combustion apparatus by using the data set determined by the data creating unit and a correcting unit for calculating combustion apparatus operation parameters with which components having a better condition than that of the components in a current gas are provided by using a model of the modeling unit and correcting operation command values of the basic control command operating unit by calculated operation parameters.

An OES measuring unit outputs a spectroscopically measured value for each step at the end of or immediately after each step. A CD estimating unit obtains an estimated CD value for each step using a CD estimation model and a spectroscopically measured value received from an estimation model storage unit. In the next step, a process control unit uses an estimated CD value for the previous step received from the CD estimating unit, in addition to a process condition setting value for the next step received from a recipe storage unit and a process control model for the next step received from a control model storage unit, for automatic control of the control subject

The invention includes a method to identify a method to enhance survival of a subject that has been exposed to a biological insult such as an ionizing radiation dose of LD50 / 30 by treating the exposed subject with a test compound an optically comparing the results to that obtained using control subjects that had been treated with 3β,17β-dihydroxyandrost-5-ene or other disclosed compounds.

The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest.

A means of measuring and monitoring skeletal growth rate using a plasma analyte, amino-terminal C-type natriuretic peptide (NT-CNP). Plasma NT-CNP concentrations reflect the potential for further growth of the immature skeleton. Measurement of plasma NT-CNP in a subject, when related to the mean of an appropriate age and gender matched set of control subjects, provides an index of the severity of a growth disorder not otherwise available and facilitates diagnosis in children with undetected osteo-chondrodysplasias or other intrinsic disorders of the growth plate. The invention also provides a means of detecting and monitoring potentially harmful effects of drugs and other factors on skeletal growth long before they are evident using current methods in clinical practice.

A method, kit and device for diagnosing Kawasaki Disease are provided. The invention provides detecting an expression level of at least two Kawasaki Disease diagnostic biomarkers in a biological sample from a patient with a capture agent and diagnosing the patient as having Kawasaki Disease when the expression levels of the at least two diagnostic biomarkers in the patient biological sample are higher than the normal expression levels of the same biomarkers in a biological sample from a control subject. The first Kawasaki Disease diagnostic biomarker disclosed in the present invention is a cardiomyocyte biomarker, and the second Kawasaki Disease diagnostic biomarker is an inflammatory biomarker. The invention further provides detecting an expression level of a third biomarker, interferon type-I biomarker, in the patient biological sample with a capture agent and diagnosing the patient as having Kawasaki Disease when the expression level of interferon type-I biomarker is lower than the expression level in a control subject.

The invention discloses an intelligent kitchen host and a work method and a control method of the intelligent kitchen host: obtaining device information of different kitchen devices, wherein the device information includes device function information, device parameter information, state monitoring interface information, control interface information and / or device identification information representing kitchen device types; and according to different kitchen device information, in a cooking control program set after a cooking control subject is analyzed, selecting a cooking control program which matches the device information so as to coordinate work of different kitchen devices and complete the whole cooking process and thus a problem of transition from a traditional kitchen to an intelligent kitchen is solved and the intelligent kitchen host has flexible control method and applicability.

There is provided a control apparatus including a function of generating an operation signal applied to a control subject and a model that simulates characteristics of the control subject, a function of receiving an evaluation value signal calculated based on a measurement signal obtained by applying the operation signal to the control subject and the model, and a function of learning to generate the operation signal such that an expected value of the sum of the evaluation value signals obtained from a present state to a future state is either maximum or minimum in which the evaluation value signal calculated based on the measurement signal from the model is calculated by adding a first evaluation value obtained based on a deviation between the measurement signal obtained from the model and a setpoint value, and a second evaluation value obtained based on a difference in characteristics between the model and the control subject.

The invention discloses a visual point burying method for a cross-platform mobile terminal. The method comprises the steps that control tree related information sent to a current interactive interfaceof a server is refreshed after a client establishes a connection with the server; the server synchronously updates a rendering interface according to the received information, and a user performs visual point burying selection operation on a control in the server; a binding condition of the control is tested, the server sends point burying information to the client, and the client confirms the control specified in the obtained point burying information and performs binding; the test of the bound control is triggered in the client, event information of the control is triggered and sent to theserver, and after the test is passed, the server performs deployment operation on the control subjected to point burying and selection. A point burying dimension self-definition function is added; thesupport of point burying of HTML elements is added; the interactive interface control is universally used for various self-defined client interactive interfaces; and for the webpage control, a visualcode injection point burying function and a similar element point burying function are supported.

The present invention relates to a method of diagnosing cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated.

This invention relates to a simultaneous control applied in magnetic suspension switch magnetic resistance motor, which comprises the following steps: adopting extensive flow control inverter, wherein the controlled magnetic suspension switch magnetism motor forms compound controlled subject; forming neural net athwart by static neural net and integral device through formula study; connecting neutral net with the compound controlled subject then compounding into two radius direction position sub system to forming anti-linear system; making the linear loop controller to the false linear system according to the linear system design; finally connecting the neural net with the linear loop controller and with the flow controlled inverter to form neural net decoupling controller.

There is provided a driving support apparatus for a vehicle. When a height of a three-dimensional object extracted as a control subject is less than a set height, and as the height of the control subject becomes lower, a driving control unit increases the range of the braking control that is sequentially inhibited in the stepwise manner from the highest braking level to the lowest braking level.

The present invention relates to a control program, a controller, and a boiler system that are related to a boiler group including a plurality of boilers controlled in combustion at stepwise combustion positions. It is well suitable, in a control program for conducting control on a boiler system that includes a boiler group having a plurality of boilers which can be controlled in combustion quantity at stepwise combustion positions and in which at least one of the combustion positions is assumed to be a high-efficiency combustion position and that is configured to be controlled in combustion based on an increase / decrease in desired loads, that in the case of increasing a quantity of combustion in the boiler group, after a high-efficiency combustion shift signal that makes the shift to the high-efficiency combustion position is output to all of the boilers subject to high-efficiency control by which control is conducted on the basis of combustion at the high-efficiency combustion position, a control signal may be output that makes the shift to a higher combustion position than the high-efficiency combustion positions for any one of the high-efficiency control subject boilers.

The invention discloses a fan as well as an air outlet control method, device and system thereof. The method comprises steps as follows: first image information of a current air supply area is acquired in a swing process; whether a preset control subject appears in the first image information is recognized by a preset model, wherein the preset control subject has a corresponding gear, the preset module is obtained through machine learning according to multiple groups of sample data, and the sample data comprises image information containing a control subject and a label for indicating whetherthe control subject in the image information is the preset control subject; under the condition that the preset control subject appears in the first image information, the gear of the fan is controlled to be adjusted to the gear corresponding to the preset control subject. The technical problem of low comfort level of a user due to the fact that a fan can only supply air according to the preset gear in the prior art is solved.

In order to provide an MRI apparatus that can efficiently approximate a specific absorption rate or a magnetic field variation rate per unit time of a magnetic flux density to a target value, the present invention is characterized in that suggestions of imaging parameters related to a control subject and change directions of the imaging parameters when the control subject is input based on an input operation and that the control unit further calculates values of the selected control subjects based on the changed imaging parameter values.

The present invention exploits the discovery that amounts of uracil and thymine metabolites, especially β-aminoisobutyric acid, in various bodily fluids, especially urine, are correlated with the occurrence of epilepsy when compared to matched control subjects. Analytical and diagnostic protocols, including a novel high performance liquid chromatography system, for use in the invention are disclosed.

A motor control device controls operation of a control object that has a motor and an oscillatable element. The motor control device comprises: a generation unit that generates, in accordance with status information that relates to the oscillation characteristics of the control object and that indicates the status of the control object, a first parameter that indicates the oscillation characteristics of the control object; a first calculation unit that calculates a second parameter in accordance with the time change amount of the first parameter generated by the generation unit; a second calculation unit that calculates a model torque using an operation target value, the first parameter, and the second parameter so that the control subject does not excite oscillation; and an issuance unit that causes a torque instruction to be issued in accordance with the model torque computed by the second calculation unit.

In adjustment of the control parameters of a magnetic suspension system, an object of the present invention is to provide a technique for adjusting the control parameters to optimum values automatically by employing the iterative feedback tuning method, without increasing the complexity of the program, the amount of calculation and the overall size of the system, and still reducing the amount of calculation required for calculation of the safety margin (gain margin and phase margin). In a method of automatic adjustment of control parameters according to the invention, when applying the iterative feedback tuning method to a feedback control system for a magnetic suspension system, only those control parameters that have a significant effect on the control performance of the system are selectively adopted / discarded from among control parameters so that the control parameters are guided to optimum values to obtain a response waveform desired by a designer directly from input / output data of a control subject.

This invention relates to a spot intelligent unit and its operation method supporting industry communication network agreement, which comprises control unit and communication port module. The communication port module realizes the MODBUS / TCP industry Ethernet agreement or DeviceNet spot bus agreement or Profibus-DP spot bus agreement. The control unit has a microprocessor connected with A / D converter, D / A converter through light couple device, wherein its switch input, output and A / D converter and D / A converter are connected with the control subject.

A method of classifying a test subject comprises collecting imaging data for a plurality of training subjects, control subjects and a test subject. An intensity volume of interest (VOI) and a morphological VOI are selected from said imaging data. Training intensity data and morphological data are calculated for the intensity and spatial VOI. A statistical model can then be created based on the training intensity data and training spatial data to provide a universe of subjects. Control intensity data and spatial data are also calculated for the intensity and spatial VOI. A classifier can then be built dividing the universe into at least two regions. The test subject data can then be applied to the classifier to provide a determination of whether the test subject falls within the first region or the second region. The condition can be a neurological disease state such as temporal lobe epilepsy or Alzheimer's dementia.

A characteristic control device which is provided with a basic control module which determines the amount of control used to control the output of a control subject based on predetermined input data and control parameters which relate output to the control subject to the input data and which controls the characteristics of the control parameters, a characteristic storage mechanism for storing the basic control parameters, and a characteristic automatic modification mechanism which determines, in accordance with predetermined conditions, and automatically modifies, the control parameters which are applied to the basic control module based on the basic control parameters stored in the characteristic storage mechanism and the input data.

A welding process for the welding of aluminium includes a force sensor measuring a force between two welding electrodes on aluminum elements to be welded and transmitting its measured values to a welding control. Until the elapse of a set welding time, the welding control calculates and stores at least one absolute value and / or at least one increase in the measured force. The welding control compares the measured absolute value and / or the increase in the measured force with a reference value and / or a reference curve and calculates a control deviation from the comparison. After the elapse of the set welding time, the welding control subjects the welding electrodes to a constant current during a welding time extension that follows the set welding time, dependent on a magnitude of the control deviation that is measured at the point in time of the elapse and / or during the set welding time.

The invention relates to an airplane seat having an audio system for playing back audio data, wherein the audio system comprises a volume controller and / or a noise compensation controller, a head rest element having a loudspeaker element that can be swiveled at a swivel angle α, and wherein the volume and / or the degree of noise compensation is controlled subject to the swivel angle α.