201 results about "Common St. Johnswort" patented technology

The invention relates to an extraction method of hyperin and application thereof in medicament preparation. The extraction method of the hyperin comprises the following steps: placing Turpinia formosana leaves or Hypericum perforatum in 30%-90% ethanol of 5-15 times, carrying out reflux extraction for 1-3 times, and filtering, wherein the reflux extraction of each time is carried out for 1-3 hours; merging the filtrates, recovering the ethanol, eluting the aqueous solution with a macroporous adsorption resin column, collecting eluted parts, carrying out depressurized concentration, and drying to obtain mixed total glycoside of the hyperin; and carrying silicagel column chromatography and Sephadex LH-20 column chromatography separation, merging hyperin fractions, and crystallizing to obtain the pure hyperin product. The hyperin can be used as a neuraminidase inhibitor for preventing and treating flu, and can be prepared into pharmaceutically acceptable dosage forms.

The invention discloses a total flavonoid from hypericum perforatum, a preparation method of a preparation thereof and a quality test method thereof. The preparation method of the invention mainly adopts the steps of degreasing, extracting ethyl acetate, and the like, which has the advantages of less loss of heat sensitivity components, stable content of effective component and better guarantee for product yield and quality compared with the prior art. The quality test method of the invention can successfully control the quality of the product and ensure the relevant efficacy of the product. The total flavonoid from hypericum perforatum and the preparation thereof have better efficacy on treating depression.

The present invention relates to the preparation process of extract containing three active components including hypericin, Hyperforin and flavones in the total content not less than 50% from hypericum perforatum or other congeneric plant. The three active components are separated from the polar solvent extracted liquid via biphase extraction with non-polar solvent selected based on their difference in polarity. They are then purified separately based on their difference in acid-base property to obtain the extract A with high hypericin and flavones content and extract B with high Hyperforin content. The two extracts are merged through dissolution to obtain hypericum perforatum extract with total active component content not less than 50%. The extract has the obvious activity of resisting depression and may be used as the material of depression treating medicine or functional food.

St. John's Wort products which have enhanced bioactivity in a serotonin re-uptake assay and enhanced stability and bioavailability are formulated and manufactured from hyperforin-enriched Hypericum fractions made by supercritical and near critical fluids with and without polar cosolvents. These fluids are used to fractionate the biomass materials in several sequential steps. In each step, the biomass is subjected to a multiplicity of supercritical or near critical fluid extraction steps, with different solvation conditions used for each fraction. Thus, fractionation of the biomass is effected and the St. John's Wort products are manufactured. In addition to excellent overall yield, the bioactivity and stability of the St. John's Wort products manufactured from Hypericum perforatum biomass with supercritical and near critical fluids with and without polar cosolvents are significantly higher than that obtained by conventional organic phase extraction. The advanced formulation of the hyperforin-enriched Hypericum fractions includes antioxidants as oxygen scavengers to improve stability and emulsifiers such as lecithin to improve bioavailability.

The invention relates to a compound antivirus immune intensifier of Chinese herbal medicine, comprising a main material, a solubilizer Tween -80 and a stabilizer vitamin C, wherein the main material of the antivirus immune intensifier comprises honeysuckle, forsythia, houttuynia, hypericum perforatum and the like. The compound antivirus immune intensifier of Chinese herbal medicine has the functions of resisting viruses, inhibiting bacteria and intensifying immunity, is taken by oral administration and injection, innovatively uses a spray method for stirring the material, effectively solves the problem of difficult uniform mixing, and also has convenient use, obvious growth promotion function and low cost.

The invention relates to a method for separating and purifying hypericins by adopting a macroporous resin separation technique and an alumina chromatographic technique. The method comprises the following steps of: grinding fresh hypericum perforatum L, leaching the ground hypericum perforatum L for 1 to 2 hours in saturated lime solution, adjusting a pH value to 6 to 7 by hydrochloric acid at normal temperature, and performing resin separation, segmented elution, alumina chromatography, ethanol elution and cyclohexane to obtain the finished product. The method has the advantages of simple process, little energy consumption and high-purity hypericins.

The invention discloses a Chinese medicinal composition for treating depression. The medicine adopts lilies, semen ziziphi apinosae, curcuma longa, hypericum perforatum L., perilla, ginseng, and radix bupleuri as raw materials, which are then separate and extracted by 0-75% ethanol so as to be prepared into certain preparation form. The above six drugs used together can soothe liver and relieve depression, reconcile and activate qi, tranquilize the mind and calm the nerves, and can be used for mild and moderate depression and patients belonging to stagnation of qi due to depression of liver, as well as heart-spleen deficiency. Pharmacodynamic research indicates that: the medicinal composition has substantial antagonistic effects on reserpine induced depression models, mouse akinesia and hypothermia, and can increase the spontaneous movements of tail suspension and forced swimming induced despair animal models, as well as the immobility time of tail suspension and swimming. Clinical research results show that a HAMD (Hamilton depression scale) used for evaluating depression severity and Chinese medicinal syndromes before and after treatment are taken as main curative effect indexes, which show that the Chinese medicinal composition in the invention has substantial curative effects. The composition provided in the invention can be prepared into medically acceptable oral preparations, such as tablets, capsules (soft capsules and hard capsules), granules, and other preparation forms. Clinical effects and pharmacodynamic research prove that the Chinese medicinal composition of the invention has the functions of liver soothing and depression relieving, mind tranquilizing as well as nerve calming, and is an effective medicine special for depression treatment.