36 results about "Barbituric acid derivative" patented technology

The present invention relates to novel non-sedating barbituric acid derivatives, pharmaceutical compositions containing them and methods of neuroprotection in cases of cerebral ischemia, head trauma and other acute neurologic injuries, and prevention of resulting neuronal damage. The invention also relates to the use of non-sedating barbituric acid derivatives given in a manner and dosage effective to produce blood levels and brain levels of these drugs and / or their active metabolites sufficient to provide a therapeutic effect.

A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the following formula: wherein R3 and R4 are each independently selected from the group consisting of lower alkyl, phenyl and lower alkyl substituted phenyl, and R1 and R2 are each independently either a hydrogen atom or a radical of the formula wherein R5 and R6 are each independently selected from the group consisting of H, lower alkyl, phenyl and lower alkyl substituted phenyl, its pharmaceutically acceptable salts, prodrugs, and metabolites thereof.

The present disclosure provides N-hydroxylamino-barbituric acid compounds of formulae (1)-(4), pharmaceutical compositions and kits comprising them, and methods of using such compounds or pharmaceutical compositions. The present disclosure provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

The present invention relates to a composition and a method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administering an oral dosage form of a sodium salt of 5,5-diphenyl barbituric acid to enhance the bioavailability of 5,5-diphenyl barbituric acid and brain delivery of same.

A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the following formula:wherein R3 and R4 are each independently selected from the group consisting of lower alkyl, phenyl and lower alkyl substituted phenyl, and R1 and R2 are each independently either a hydrogen atom or a radical of the formulawherein R5 and R6 are each independently selected from the group consisting of H, lower alkyl, phenyl and lower alkyl substituted phenyl, its pharmaceutically acceptable salts, prodrugs, and metabolites thereof.

In one aspect, the present invention relates to compounds of Formula (I): to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to method for theirpreparation.

To provide a polyamide resin composition containing an added crystal nucleator suitable for promoting the crystallization of a polyamide resin and not triggering discoloration in the resin, the polyamide resin composition being capable of raising the crystallization rate and achieving better molding process properties and heat resistance in comparison with the polyamide resin. A polyamide resin composition including a polyamide resin and a crystal nucleator comprising a carboxylic acid derivative represented by formula [1]. B1-L1-A-L2-B2 [1] (In the formula, A represents an optionally substituted C1-6 alkylene group or C6-10 divalent aromatic group, B1 and B2 represent optionally substituted C3-6 cycloalkyl groups or optionally substituted C6-10 aromatic groups, and L1 and L2 represent -C(=O)NR1- or -C(=O)O-.).

The invention provides barbituric acid derivatives and a preparation method thereof. The barbituric acid derivatives provided by the invention introduce fluorine atoms which have small radiuses and high electronegativity, and the bond energy of formed C-F bonds is higher than that of C-H bonds, thereby improving the stability and bioactivity of organic fluorine compounds; and the organic fluorinecompounds have relatively higher lipid solubility and relatively higher hydrophobicity. The barbituric acid derivatives provided by the invention introduce thiophene at the same time of introducing the fluorine atoms so as to achieve higher potential bioactivity and be easier to absorb. In-vitro antibacterial tests show that the compounds have a relatively better inhibiting effect on tested bacteria, and can be further developed as antibacterial agents or leading compounds. In the preparation method provided by the invention, a solvent-free one-step synthesis method is adopted; and the preparation method has the advantages of readily-available raw materials, simple operations, environmental-friendliness, high yield and the like.

The invention provides a barbituric acid derivative, a preparation method thereof, and an application of the derivative in data encryption and decryption. The chemical structure of the barbituric acidderivative is represented by formula I shown in the description. The barbituric acid derivative has the characteristic of crystallization-induced emission enhancement, and can be used for data encryption and decryption.

The invention discloses a thiobarbituric acid derivative molecule modified molybdenum disulfide two-dimensional nano material with diversified hydrophilic and hydrophobic properties and charges, whichis a molybdenum disulfide nano material respectively modified by Ligand 1-Ligand 9 ligand molecular compounds shown as formulas (I) to (IX), and is sequentially named as MoS2 <-1>-MoS2 <-9>. The invention also discloses an application of the molybdenum disulfide nano material in preparation of drugs and drug carriers for inhibiting tumor cell growth, or in preparation of paclitaxel-loaded drug complexes for inhibiting tumor cell growth as a drug carrier. The experiments prove that the thiobarbituric acid derivative molecule modified molybdenum disulfide two-dimensional nano material with diversified hydrophilic and hydrophobic properties and charges is expected to become a potential drug or drug carrier for tumor synergistic treatment, and has broad scientific research and clinical application prospects.