81 results about "Arthritis gout" patented technology

The invention provides a novel Lesinurad midbody and provides a synthesis process of Lesinurad, which is economic, efficient, safe, environment-friendly and applicable to large-scale industrial production. The invention further provides a method for preparing the conventional Lesinurad midbody and Lesinurad by using the novel Lesinurad midbody. When synthesized from the novel Lesinurad midbody provided by the invention, the Lesinurad has advantages that the price of necessary raw materials is low, the raw materials are easy to obtain, heavy metal and solvents which are harmful to the environment are not used, the midbody and a product can be easily separated and purified, the operation is easy, application of thiophosgene which is high in toxicity and not easy to operate is avoided, and the total reaction yield is approximate to or higher than that in the prior art.

The invention relates to Febuxostat and a drug combination thereof, wherein the Febuxostat is Febuxostat crystal, belonging to monoclinic system, the space group of the crystal is P2 (1), and cell parameters comprise a=4.7179 (9), b=17.813 (4), c=10.690 (2), alpha=gamma=90 degrees, and beta=99.20 (3) degrees; and the cell volume is 886.8(3) <3>. In addition, the invention also relates to a drug composition containing the Febuxostat crystal and a preparation method of the crystal, and simultaneously the invention further discloses application of the Febuxostat crystal in treating hyperuricemia comprising primary and secondary hyperuricemia, acute and chronic gout, gouty arthritis, gouty nephropathy and renal calculus which are caused by the hyperuricemia.

The present invention is related to a bilayer pharmaceutical composition comprising naproxen or a pharmaceutically acceptable salt thereof. The present invention is particularly related to a bilayer pharmaceutical composition comprising an immediate release component and a controlled release component of naproxen or a pharmaceutically acceptable salt thereof and the process for preparation thereof. Moreover, the present invention is related to the treatment of rheumatoid arthritis, oesteoarthritis, ankylosing spondylitis, pain, primary dysmenorrhoea, acute tendinitis, bursitis and acute gout.

The invention relates to a pharmaceutical composition for treating gout and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. The composition is prepared from medicinal materials such as fineleaf schizonepeta herb, cassia twig and the like, and has good effect.

The invention relates to a composite sunflower composition for reducing uric acid and alleviating gout and a preparation method and application of the composite sunflower composition, and belongs to the technical field of functional foods. In order to solve the problems that a conventional gout treatment drug is small in side effect, complex in components and the like, through methods of extraction, enzymolysis, molecular weight interception and the like, a preparation method of a sunflower extract, a preparation method of a coix seed extract and a preparation method of a lophatherum herb extract are optimized, and the obtained extracts are rich in effective components of micromolecule weight active glycoconjugate, flavone, alkaloid and the like. The invention further provides the composition consisting of 80-120 parts by weight of the sunflower extract, 10-30 parts by weight of the coix seed extract, 5-15 parts by weight of the lophatherum herb extract and 50-70 parts by weight of themaltodextrin and a preparation method of the composition. The invention can be used for development of health-care products and drugs for improving the gout and / or hyperuricaemia.

The invention relates to an anti-gout composition, a preparation method and an application thereof in the preparation of anti-gout drugs, and the composition comprises the following pharmaceutical raw materials by weight ratio: 160-220 parts of Indian iphigenia bulb, 120-180 parts of rhubarb or Chinese paris rhizome, 100-150 parts of garden balsam stem and 3-8 parts of borneol or menthol. The optimized weight ratio is as follows: 180 parts of Lijiang Indian iphigenia bulb, 150 parts of rhubarb or Chinese paris rhizome, 120 parts of garden balsam stem and 5 parts of borneol or menthol. The pharmaceutical raw materials are prepared into 1000ml or 1000g. The further optimization is that the pharmaceutical raw materials comprise the rhubarb or the Chinese paris rhizome, extracts of the Lijiang Indian iphigenia bulb and the garden balsam stem and solution of the borneol or the menthol. The invention further provides the preparation method of the anti-gout composition and the application of the anti-gout composition in the preparation of the anti-gout drugs. The invention provides the effective anti-gout traditional Chinese medicine composition for making up for the deficiency that the prior art is lack of the anti-gout drugs prepared by traditional Chinese medicine. The anti-gout composition can obtain better anti-gout treatment effect.

The invention discloses a compound with an effect of treating and preventing hyperuricemia or gout and a preparation method as well as application thereof. The general structural formula of the compound is shown as a formula (I); the proportion of lesinuard and an allopurinol medicament can be effectively controlled by the series of the compounds, the dose and frequency are reduced, the effect of combination medication can be achieved by single-time medication, meanwhile the preparation process can be simplified, and the production cost is saved; since a linking group exists between the two compounds, the compound can only be hydrolyzed into two medicaments under the action of an enzyme for a certain time after the compound is orally taken and absorbed; thus, the half-life in vivo of the compound is increased by the process, namely the medicament achieve a slow release effect through a chemical coupling method.

The invention particularly relates to a xanthine oxidase inhibitory peptide. The amino acid sequence of the xanthine oxidase inhibitory peptide is Glu-Glu-Ala-Lys (EEAK). The IC50 value of the tetrapeptide EEAK on xanthine oxidase inhibitory activity is 173.00+ / -0.06 [mu]M, the tetrapeptide EEAK has a continuous and stable inhibitory effect on xanthine oxidase, and the tetrapeptide EEAK has the outstanding advantages of safety, no toxic or side effect, easiness in absorption, industrialization and the like. The active tetrapeptide EEAK or the derivative thereof can be used for preparing gout treatment / prevention medicines or used as a functional food additive for long-term treatment and health care of gout patients, and has a wide application prospect and very important significance.

The invention discloses a Chinese herbal compound preparation used for treating alcoholism and gout, mainly comprising the following components in parts by weight: 10-40 parts of kudzuvine root, 15-40 parts of hovenia acerba, 3-10 parts of pseudo-ginseng, 3-15 parts of phyllanthus emblica, 3-10 parts of fructus amomi, 35-10 parts of myristica fragrans, 3-15 parts of dchisandra chinensis, 4-15 parts of American olive, 10-20 parts of honeysuckle, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of coix seed, 10-30 parts of poria cocos, 10-20 parts of zaocys dhumnade, 10-20 parts of lucid ganoderma, 10-20 parts of American ginseng and 10-20 parts of turmeric. No hepatorenal dysfunction is caused when the compound preparation disclosed by the invention is used for treating hyperuricosuria, which shows that the preparation has no obvious toxic or side effect and mild medicine property, thus the preparation is beneficial to long-term administration. The inventor also knows that medicine taking compliance of patients and tolerance are good from some follow-up visited patients, annual attack frequency is reduced, and the preparation disclosed by the invention has obvious treatment effect on combined diabetes mellitus, hyperlipidemia and vascular hypertension, thus the preparation disclosed by the invention can be regarded as a safe Chinese herbal compound preparation which can be taken by a patient who is repeatedly attacked by acute gouty arthritis for a long time and can control symptoms and reduce attack frequency.

The invention relates to a humanized anti-human-interleukin-1[belta] monoclonal antibody, preparation thereof and applications thereof. The light chain of the monoclonal antibody has an amino acid sequence shown as SEQIDNO:1, and the heavy chain of the monoclonal antibody has an amino acid sequence shown as SEQIDNO:2. The antibody can be used for treating various diseases such as acute gout, rheumatoid arthritis, II-type diabetes, non-infectious uveitis, etc. which are related to interleukin 1[belta] pathological functions.

The invention discloses a common St. Paulswort herb leaf extract which takes leaves of the common St. Paulswort herb as the raw material and is obtained by means of alcohol-extraction. The invention also discloses a method for preparing the common St. Paulswort herb leaf extract and further discloses a pharmaceutical composition taking the common St. Paulswort herb leaf extract as the active component; in addition, the invention also discloses the application of the common St. Paulswort herb leaf extract in the aspect of curing rheumatic arthritis, rheumatoid arthritis, gout, scapulohumeral periarthritis and other diseases.

A Chinese medicine in the form of extrerior-applied powder for treating recurrent gout is prepared from 4 Chinese-medicinal materials including rhubarb, tangerine peel, etc. Its preparing process is also disclosed.

The invention provides a traditional Chinese medicine composition for treating hyperuricemia and gouty arthritis, which comprises the following ingredients in parts by weight: 500-1500 parts of Smilax smilax, 300-900 parts of Mianzi, 100-500 parts of honeysuckle, 50-50 parts of vinegar Corydalis 250, Shanzi mushroom 50-150, and medicinal excipients. Provided is a preparation method of a traditional Chinese medicine composition for treating hyperuricemia and gouty arthritis of rheumatic stagnation-heat type, and is used for treating gout and hyperuricemia. The effect of the present invention is that the traditional Chinese medicine composition overcomes the disadvantages of traditional dosage forms such as decoction, adopts the method of water extraction, retains the active ingredients with clinical curative effect in the composition, and adopts high-efficiency dynamic circulation extraction equipment to extract effective ingredients, to ensure its clinical efficacy. The preventive and therapeutic effects on hyperuricemia and rheumatism-heat-type gouty arthritis are obviously better than similar drugs.

The invention discloses a preparation method of a compound three-snake powder composition. The compound three-snake powder has very good treatment efficacy on autoimmune diseases, can be used to fast and well treat rheumatoid arthritis, can be used to well treat gout, hypertension and ankylosing spondylitis, and can also used to realize beauty treatment, face nourishing and ageing delaying. The compound three-snake powder comprises, by weight, 10-30 parts of pit viper powder, 25-56 parts of zaocys dhumnade powder, 30-55 parts of dinodon rufozonatum snake powder, 10-15 parts of American ginseng, 5-8 parts of peach blossom, 6-9 parts of licorice root, 9-12 parts of Poria cocos, 5-7 parts of Spica Prunellae, 3-5 parts of unprepared Atractylodes lancea, and 10-15 parts of Herba Leonuri, and can be used to prepare various dosage forms, such as a tablet and a capsule.

The present invention relates to a 2-arylbenzofuran derivative which has antioxidant activity and xanthine oxidase inhibitory activity and is useful in preparation of anti-oxidation and gout and hyperuricemia treating compositions, drugs and health products.

The invention belongs to the field of chemical medicines, and in particular relates to new application of polyacetylenes. The invention discloses polyacetylene with a structure shown as a formula (I)and application of pharmaceutically acceptable salts, esters, prodrugs, solvates, polymorphic substances, hydrates or derivatives of the polyacetylene combined with hyperuricemia medicines in preparation of combined medicines for treating hyperuricemia. The invention also provides a hyperuricemia pharmaceutical composition, which comprises the above compound and one of febuxostat or allopurinol. The hyperuricemia pharmaceutical composition can achieve the uric acid reducing effect equivalent to or even better than that of a hyperuricemia medicine in the prior art, but can obviously reduce thetoxic and side effects of the hyperuricemia medicine and improve the safety, and can be used for treating hyperuricemia and gout or gout complications caused by hyperuricemia.

The invention discloses an application of icariin in preparation of medicaments for treating gout. According to the application disclosed by the invention, the icariin is used for preparing the anti-gout medicaments, and animal experiments prove that a pharmaceutical composition prepared from the icariin can prevent and treat gouty arthritis, including acute gouty arthritis and chronic gouty arthritis. The material is wide in sources and easy to obtain, and the icariin is simple and easy to be used for preparing the medicaments and good in treatment effects.

The invention provides an application of salidroside in preparation of a medicine for resisting gouty arthritis, and particularly relates to prevention and curing functions of salidroside on acute gouty arthritis. The salidroside has the benefits as follows: the salidroside has prevention and curing functions on gouty arthritis, especially acute gouty arthritis. The animal experiment proves that sodium urate induced acute gouty arthritis can really be relieved by the salidroside. Therefore, when the salidroside is applied to preparation of the medicine for resisting gouty arthritis, one natural or natural-like medicine can be provided for treatment of gouty arthritis, and adverse effects caused by the medicine for treating gouty arthritis are reduced.

The invention relates to enzymes, in particular to a pine needle enzyme with an immunity boosting function and a preparation technology of the pine needle enzyme. The pine needle enzyme formula comprises raw materials in percentage by weight as follows: 50%-70% of pine needles, 5%-10% of conifer cones, 3%-8% of lemons, 2%-5% of kiwi fruit, 5%-10% of oranges and 5%-10% of pine twigs. The enzyme adopting the formula has remarkable effects on generally common chronic diseases such as hypertension, hyperlipidemia, hyperglycemia, fatty liver, gout, cerebral arteriosclerosis, sexual debility, rheumatoid arthritis, insomnia, physical weakness, prostatitis, constipation, obesity and the like as well as detoxification and beauty maintenance, and is applicable to wide sub-healthy people.

The invention relates to a pharmaceutical composition for treating gout and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. The composition is composed of medicinal materials such as salvia miltiorrhiza, giant knotweed and the like, and has good effect.

The invention relates to a lesinurad analog as shown in the general formula (I), its preparation method, a pharmaceutical composition containing the derivative and an application of the pharmaceutical composition used as a therapeutic agent, especially as a medicine for treating hyperuricemia and gout, wherein definition of each substituent group in the general formula (I) is as the same as definition in the specification.

The invention discloses application of plant pectin in products for treating gout and provides a plant pectin tablet product and a preparation method thereof. The plant pectin tablet product comprises the plant pectin, maltodextrin, ultrafine rice hull powder, a filling agent, a disintegrating agent and a lubricating agent. The plant pectin tablet product forms a novel composition for treating the gout and opens up a new direction for the treatment of gout patients. Raw materials for preparing the composition for treating the gout can be used in food and are free of side effect. The preparation method is simple, practicable and convenient in industrial production. The plant pectin tablet product capable of effectively treating the gout is small in auxiliary material use amount, even in pectin dispersion, good in tablet disintegration performance, good in tablet stability and high in bioavailability. The invention provides application of the pectin in the preparation of healthcare food for resisting hyperuricemia and the gout and expands the resource range of drugs or healthcare food for resisting the hyperuricemia and the gout.

The invention relates to traditional Chinese medicine composition for treating gout. The traditional Chinese medicine composition is prepared from raw materials in parts by weight as follows: 2-10 parts of amur corktree bark, 5-8 parts of swordlike atractylodes rhizomes, 7-20 parts of glabrous greenbrier rhizomes, 4-9 parts of plantain herbs, 3-10 parts of oriental waterplantain rhizomes, 5-12 parts of dandelion, 6-10 parts of honeysuckle, 3-14 parts of indigowoad roots, 10-20 parts of scandent schefflera stems and leaves, 4-20 parts of weeping forsythiae capsule, 6-8 parts of dwarf lilyturf tubers, 3-6 parts of cape jasmines, 2-7 parts of chicken's gizzard-membranes, 8-10 parts of cherokee rose fruits, 2-5 parts of fragrant solomonseal rhizomes, 7-10 parts of tortoise plastron, 3-6 parts of sharpleaf galangal fruits, 1-8 parts of clematis roots, 4-7 parts of cassia seeds, 3-6 parts of herbs of spicate clerodendranthus, 4-9 parts of fineleaf schizonepeta herbs and 10-20 parts of snake gallbladder. Granules prepared with a preparation method are convenient to take, taste good, take effect quickly and have a certain treatment effect on obesity complicated with acute gouty arthritis, diabetes, hypertension, hyperlipemia and the like.

The invention relates to the fields of organic synthesis and pharmaceutical chemistry, and specifically relates to a cleistanone derivative, a preparation method thereof, and an application of the cleistanone derivative in the preparation of drugs for treating acute gout. A novel cleistanone derivative is synthesized, and a preparation method thereof is disclosed. The pharmacological experiments show that the cleistanone derivative has an effect on resisting acute gout and can be used to develop drugs for treating acute gout.

The invention relates to a drug chemical compound for gout. The drug chemical compound has the structure as shown in the following formula I. The invention further relates to a method for preparing the drug chemical compound of the formula I. The method comprises the step of using an organic solvent for refining the chemical compound of the formula I. The drug chemical compound for gout has good pharmaceutical properties.

The invention discloses a pharmaceutical composition for treating gout and application thereof. The pharmaceutical composition is prepared from the following medicines in parts by weight: 500 to 3000parts of curcumin, 200 to 3000 parts of quercetin, 500 to 3000 parts of lemon-grass extract, and 1000 to 5000 parts of frankincense. The pharmaceutical composition has the advantages that the excellent anti-gout effect is realized; the pharmaceutical composition is used for preparing medicines, health-care products or foods for treating or preventing gout arthritis and / or hyperuricemia; the side effect is small, the cost is low, the preparation method is simple, and the industrialized production is easy.

The invention discloses a preparation method and application of a plant extracting solution for reducing the blood uric acid concentration of the human body. The plant extracting solution is used forreducing the blood uric acid concentration and treating gout caused by hyperuricemia. The invention relates to the technical field of plant extraction and biological pharmacy. The preparation method comprises the following steps of S1, extracting an immersion solution: mixing one or more of radix astragali, fructus gardeniae and radix curcumae longae with water and performing heating to obtain a water extracting solution; S2, performing filtering: filtering the water extracting solution obtained in the step S1 through a filter membrane to remove impurities, so as to obtain a water extracting refined filtrate; S3, performing oxidation: filling the water extracting refined filtrate obtained in the step S2 with edible or medical oxygen for mixed oxidation to obtain a water extracting refinedfiltration and oxidation solution; and S4, performing filling and sterilization: filling an oral liquid bottle with the water extracting refined filtration and oxidation solution obtained in the stepS3, and performing sterilization at a high temperature to obtain the finished plant extracting solution. The preparation is simple and convenient, and the extracting solution produced according to thepatent of the invention has the effects of obviously reducing the blood uric acid concentration of the human body and treating the gout.

The invention relates to the technical field of traditional Chinese medicines, and especially relates to a traditional Chinese medicinal composition for treating pains in waist, legs, muscles and bones, and a preparation method thereof. The method adopts ginseng, Pyrola calliantha, Semen Strychni, Herbal Ephedrae, Incised Notopterygium, Radix Angelicae Pubescentis, cassia twig, frankincense, Achyranthes bidentata, myrrh, Eucommia ulmoides, Rhizoma Homalomenae, peach kernels, Radix Aconiti Preparata, Veronicastrum sibiricum, Chinese angelica root, Salvia miltiorrhiza and Kadsura Pepper Stem asraw materials, and the raw materials are reasonably combined to jointly act in order to fuse beneficial effects of all the raw materials, eliminate toxic and side effects and fully show and fuse the effects of all the raw materials, so the safe and nontoxic traditional Chinese medicinal composition being able to strengthen tendons and bones, relax muscles and stimulate blood circulation and used for aching lumbus, limp legs, limb numbness, rheumatic arthralgia, hyperostosis, rheumatism, joint and muscle swelling pains, acute gout, hypertrophic spondylitis, degenerative spondylitis, arthritis,strain of lumbar muscles, sciatica, and paralysis in the hands and feet with low back pains; and the raw materials are easy to obtain.

The invention belongs to the field of medicinal chemistry, and particularly relates to a URAT1 inhibitor and application thereof, in particular to a compound with a structure shown as a formula (I) or a formula (II) or pharmaceutically acceptable salt thereof. Experiments show that the compound provided by the invention has a very good inhibition effect on hURAT1 transport uric acid in HEK293 transfected cells, and the compound has a good application prospect in the aspect of treating hyperuricemia or gout.

The invention discloses an indole derivative as well as a preparation method and application thereof, belongs to the technical field of medicines, and particularly relates to an indole derivative as shown in a general formula I, the invention also relates to a preparation method of the compound, a pharmaceutical composition taking the compound as an active component, and application of the compound in preparation of anti-gout drugs.