Application of icariin in preparation of medicaments for treating gout

A kind of icariin and treatment technology, applied in the field of pharmacy, can solve the problems such as no anti-gout

Active Publication Date: 2013-07-24
广西神力制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report of anti-gout

Method used

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  • Application of icariin in preparation of medicaments for treating gout
  • Application of icariin in preparation of medicaments for treating gout
  • Application of icariin in preparation of medicaments for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1 of the present invention: get 5 g of icariin, 75 g of medicinal starch, and 20 g of microcrystalline cellulose, dry the medicinal starch first, pass through a 120 mesh sieve, and then mix with icariin and microcrystalline cellulose Mix, pass twice 120 mesh sieves, fill in the hard capsule, make 1000 capsules of the present invention. Each hard capsule contains 0.5 mg of the main ingredient.

Embodiment 2

[0062] Embodiment 2 of the present invention: icariin 5g, hypromellose 6g, sodium starch glycolate 10g, microcrystalline cellulose 8g, lactose 115g, starch 50g, magnesium stearate 1g; After mixing, put it into a high-speed blender, spray and add appropriate amount of water, granulate, control the water content at 3~4%, and then compress into tablets to make 1000 tablets, coated with film.

Embodiment 3

[0063] Example 3 of the present invention: Add 5 g of icariin, add 400 ml of polyethylene glycol 200 to dissolve, then add an appropriate amount of distilled water to dilute, then add an appropriate amount of sucrose and adjust the volume to 1000 ml, stir well, filter, and fill into 10 ml or 20 ml each, sterile packaged.

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Abstract

The invention discloses an application of icariin in preparation of medicaments for treating gout. According to the application disclosed by the invention, the icariin is used for preparing the anti-gout medicaments, and animal experiments prove that a pharmaceutical composition prepared from the icariin can prevent and treat gouty arthritis, including acute gouty arthritis and chronic gouty arthritis. The material is wide in sources and easy to obtain, and the icariin is simple and easy to be used for preparing the medicaments and good in treatment effects.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of icariin in the preparation of medicines for treating gout. Background technique [0002] Gout is caused by purine metabolism disorder and decreased uric acid excretion, and its incidence is increasing year by year. The incidence rate varies from country to country, and the incidence rate in Asia has gradually increased in the past 10 years. According to foreign data, the incidence of hyperuricemia in adults is as high as 5%, and the prevalence of gout is as high as 0.13%-0.37%. With the continuous improvement of people's living standards in our country, people's diet structure has changed a lot, high in purine, high in protein and high in fat. In the 21st century, gout has become the second largest metabolic disease in humans after diabetes. The clinical features are: hyperuricemia, recurrent episodes of acute arthritis, tophi formation, chronic arthritis and joint d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P19/06
Inventor 龚其海李利生李菲石京山
Owner 广西神力制药有限公司
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