The invention relates to a multi-angle machining device and a multi-angle machining method for PVC transparent plastic plates. The device comprises a bottom plate, a grinding device, and a moving device. The grinding device and the moving device are separately mounted on the upper end surface of the bottom plate from left to right. The grinding device comprises a grinding support frame, grinding fixing mechanisms, a grinding bearing plate, grinding half gear discs, grinding gear discs, grinding adjusting motors, grinding connecting plates, infrared lamps, adjusting dials, adjusting dial supports, a grinding rotating motor, and a grinding disc. The grinding support frame is mounted on the left side of the upper end surface of the bottom plate. The grinding fixing mechanisms are mounted in the middle of the grinding support frame. According to the multi-angle machining device and the multi-angle machining method for PVC transparent plastic plates, the problems of measuring the grinding angle is difficult, the grinding angle is not accurate, the grinding effect is poor, and the like when the multi-angle grinding of the PVC transparent plastic plates are performed can be solved; the function of multi-angle grinding of the PVC transparent plastic plates can be realized; and the grinding device has the advantages of being convenient to measure the grinding angle, flexible in grindingangle adjustment, accurate in grinding angle control, and good in grinding effect.