43results about How to "Reduce visceral fat" patented technology

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive impairment, decreased libido, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

The invention discloses a strain for preventing and treating metabolic diseases and application for the strain. The strain is Akkermansia muiniphila strain which is named Akkermansia muciniphila SSYD-3 and has the preservation number being CGMCC No.14764. Compared with the existing Ackermann muiniphila strain ATCC BAA 835, the Akkermansia muiniphila strain provided by the invention is more ideal in fermentation performance, storage stability, acid resistance, bile salt tolerance and the effect of treating the metabolic diseases.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

A composition for relieving stress and / or disorder caused by stress is provided, which composition comprises lysine and arginine as active ingredients. The lysine and arginine may be in the form of a salt. In a preferred mode, the cause of stress is any one selected from the group consisting of mental strain, repetitive work, intellectual labor, menopausal mental instability, anxiety and strain with respect to a future event and premenstrual mental instability and strain.

Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

The present invention has its object to provide an agent for preventing and / or ameliorating life style-related diseases which contains, as an active ingredient, a substance derived from a safe food material having a long history of being eaten as a food and which is capable of being utilized as functional foods such as health foods or functional health foods (specific health foods, functional nutritive foods). The agent for preventing and / or ameliorating life style-related diseases according to the invention contains, as an active ingredient, at least one compound selected from the group consisting of ar-turmerone, +--turmerone, -turmerone, curlone, bisacumol and -sesquiphellandrene, or at least one compound selected from among the bisabolane type sesquiterpenoids derived from Curcuma longa L., and therefore is useful for preventing and / or ameliorating diabetes, visceral fat obesity, metabolic syndrome and obesity, among others.

Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Compounds of structural Formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive impairment, decreased libido, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

The invention discloses a medicinal composition with antioxidant activity and a blood vessel and blood cleaning antioxidant and / or protective agent. The medicinal composition comprises the following raw materials in part by weight: 1 to 60 parts of grape seed, 10 to 200 parts of fresh apple, 5 to 80 parts of blueberry, 10 to 200 parts of piny flower, 5 to 60 parts of lemon, 20 to 80 parts of hawthorn, 5 to 50 parts of purple salvia miltiorrhiza, 5 to 50 parts of mulberry, 10 to 50 parts of Chinese wolfberry, 10 to 50 parts of codonopsis pilosula, 10 to 50 parts of rhodiola, 50 to 200 parts of glutinous rice bran; 5 to 50 parts of epimedium herb and 1 to 10 parts of zinc gluconate or ferrous gluconate or a mixture of the zinc gluconate and the ferrous gluconate. The invention has high bioavailability, is easily digested and absorbed, has no pessimal stimulation to gastrointestinal tracts, and can exert the effect of primary anthocyanidin extracted from different plants and plant seeds to the greatest degree.

The invention discloses a traditional Chinese medicine prescription for treating an overweight / obesity type polycystic ovary syndrome. A basic prescription is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 to 30 parts of radix codonopsis, 5 to 15 parts of bighead atractylodes rhizome, 5 to 15 parts of poria cocos, 3 to 9 parts of cassia twig, 3 to 9 parts of radix et rhizoma rhei, 5 to 15 parts of herba artemisiae capillariae, 5 to 15 parts of rhizoma alismatis, 5 to 15 parts of rhizoma sparganii, 5 to 15 parts of rhizoma curcumae, 5 to 15 parts of herba epimedii and 3 to 6 parts of prepared liquorice root. The traditional Chinese medicine prescription disclosed by the invention has refined compatibility and basic traditional Chinese medicineraw materials are adopted; metabolism and reproductive-endocrine disorder are considered, the difficult of researching and developing overweight / obesity type polycystic ovary syndrome medicines at present is smoothly solved and a satisfied curative effect is obtained. The prescription is a traditional Chinese medicine compound prescription considering the metabolism and the reproductive-endocrinedisorder; the prescription is simple and the effect is clear; the prescription has a wide popularization prospect in clinical application, and is prepared into various Chinese patent drugs with different preparations so that the prescription is more convenient for patients; the total cost is low so that the financial burden of the patients can be alleviated to the great extent and the medical burden of China is alleviated to a certain extent.

The invention aims to provide a preparation method of multifunctional cooking oil. The method is characterized by adding lipase into mixed oil with animal oil and vegetable oil to accelerate generation of diglyceride. The cooking oil is rich in various nutritional components such as saturated fatty acid, monounsaturated fatty acid, polyunsaturated fatty acid and diglyceride, and has functions of balancing nutrition value and protecting health.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

The invention discloses a traditional Chinese medicine prebiotic composition, and a preparation method and an application thereof. The composition is composed of the raw materials in parts by weight:10-100 parts of onions, 5-50 parts of Chinese yam, 5-50 parts of cyclocarya paliurus leaves and 2-30 parts of grape seed extracts. The method comprises the steps: respectively crushing the onions, Chinese yam and cyclocarya paliurus leaves, mixing to obtain a mixture, adding water, soaking, decocting, and filtering to obtain an onion, Chinese yam and cyclocarya paliurus leaf extract; and then mixing the onion, Chinese yam and cyclocarya paliurus leaf extract with a grape seed extract to obtain the traditional Chinese medicine prebiotic composition. According to the traditional Chinese medicinecomposition disclosed by the invention, few medicines are adopted, through reasonable compatibility, the effects of reducing waist and abdomen circumference, reducing visceral fat, promoting the quantity of bifidobacteria and lactic acid bacteria and resisting inflammation are remarkable, and no side effect is caused.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

The invention discloses a functional meat sausage taking whole sheep hoof leather bag as casing and a preparation method of the functional meat sausage. The sausage is prepared through the steps of using a hollow leather bag obtained after muscles and bones of a fresh rumex japonicas are removed as a casing, preparing a stuffing by adding the following raw materials in percentage by weight into every 1,000 g of lean pork: 20-30% of fat meat (pig backfat and lard diglyceride are mixed in a mass ratio of 9: 1), 12-15% of high-crosslinking corn starch, 1.0-2.0% of ultrahigh-pressure soybean protein isolate hydrolysate, 0.05-0.1% of a liquorice root extract, 0.4-0.6% of an ultrahigh-pressure glycosylation product of psyllium seed gum and soybean protein isolate, 0.8-1.0% of pig bone marrow milk slurry, 0.2-0.4% of a flatfish bone paste lactic acid fermentation product, 0.3-0.5% of drunken oxygen garlic, 40-50% of hydrogen-enriched ice water and other seasoning ingredients, and adopting processes of chopping, encapsulating, tying, cooking, fumigating and the like to prepare a hydrogen-enriched, high-calcium and anti-cancer functional pork sausage. Advanced modern instruments and equipment are adopted in the production process, and time saving, quickness and environment friendliness are achieved. The prepared meat sausage has outstanding functions, and solves the problem of single and insufficient functions of traditional meat sausage products.

The invention discloses a method for processing frost snow preserved meat. The method mainly comprises the following steps: step 1, pickling, cleaning, airing and smoking raw material meat so as to obtain preserved meat blank; step 2, applying frost snow generating liquid on the surface of the meat blank to obtain pretreated meat blank, wherein the frost snow generating liquid mainly comprises oneor more of the following components in parts by weight: 0.01-0.1 part of 10 w / g protease, 0.01-0.1 part of 10 w / g lipase, 0.01-0.1 part of arginine, 0.01-0.1 part of leucine, 0.01-0.1 part of glutamic acid, 0.01-0.05 part of tyrosine, 0.01-0.1 part of alanine, staphylococcus xylosus with a concentration of (0.5x10<5>) to (8x10<6>) cfu / mL, and plant lactobacillus with a concentration of (0.8x10<5>) to (2x10<6>) cfu / mL; and step 3, conducting vacuum packaging on the pretreated meat blank, and conducting culturing at 25-40 DEG C until a white frost snow layer forms on the surface of the meat blank so as to obtain the frost snow preserved meat. The obtained frost snow preserved meat has white flavor substances on the surface, is novel in form, obvious in characteristics and rich in nutrients,has good efficacy of promoting appetite, dispelling cold and promoting digestion, and is more suitable for the consumption requirements of special consumer groups with hyperlipidemia and hypertension.

The invention relates to substituted N-(4-oxo-3,4-dihydroquinazolin-2-yl)butanamid derivatives which modulate androgen receptors to treat conditions such as: osteoporosis, peridontal disease, bone fracture, frailty, and sarcopenia.

The invention provides a glucose-resistant feature beautifying composition and a preparation method thereof. The composition comprises white kidney bean extract, blood orange concentrated powder, pueraria flower isoflavone, a seaweed extract, green coffee powder, opuntia ficus-indica powder and aloe vera extract. Through the green coffee powder, the pueraria flower isoflavone and the seaweed extract, glucose absorption is reduced, fat absorption is controlled, amylase activity is inhibited, conversion and absorption of glucose-starch-fat are effectively reduced from a three-dimensional angle,excretion is promoted, and the optimal weight control effect is achieved by adjusting / balancing energy. Starting from the physique of Chinese people, the composition disclosed by the invention reasonably matches functional components and inhibits starch absorption, so that the weight is controlled, and on the basis of losing weight, the composition reasonably regulates and controls the body, perfectly shapes, supplements water, moisturizes and maintains the vitality state of the skin.

The invention relates to the technical field of microbial fermentation, and discloses monascus purpureus, a fermentation method and an application of a fermentation product to preparation of productscapable of reducing fat of internal organs. The invention provides the monascus purpureus (Monascus purpureus) SHM1105 which is preserved in the China General Microbiological Culture Collection Center, the preservation number is CGMCC No.15369, and the preservation date is 21 March, 2018. The fermentation method of the bacterial strain is optimized, and monascorubin of the bacterial strain is prepared. Animal experiment verifies that the monascorubin obtained by the optimized fermentation method has the advantage of being high in color number, and besides, animal experiment data indicates thatthe monascorubin also has the functions of reducing cholesterol, reducing weight and reducing fat of internal organs.

The invention relates to the field of biology, and discloses a composition for reducing visceral fat based on microencapsulated red yeast rice and a preparation method thereof. The composition includes microencapsulated red yeast rice, natto, green tea extract, mulberry leaf extract and purple Su oil; the microencapsulated red yeast rice includes a core material and a capsule material; the core material includes a red yeast pigment or a mixture of a red yeast pigment and a red yeast rice. In the present invention, microencapsulated red yeast rice, natto, green tea extract, mulberry leaf extract and perilla oil are compounded, and the red yeast rice is prepared into microcapsules by using microencapsulation technology. Oxidation occurs due to the influence of various factors. On the other hand, microencapsulation is beneficial to improve the taste of the product and enable the slow release of active substances.

The invention relates to the technical field of microbial fermentation, and discloses a monascus purpura, a fermentation method and an application of a fermentation product in preparing products for reducing visceral fat. The invention provides a strain of Monascus purpura ( Monascus purpureus ) SHM1105, the strain is preserved in the General Microbiology Center of the China Committee for the Collection of Microbial Strains, with the preservation number CGMCC No.15369, and the preservation date is March 21, 2018. By optimizing the fermentation method of the strain, the monascus pigment of the strain was prepared. Through animal experiments, the monascus pigment obtained through the optimized fermentation method not only has the advantage of high color value, but also has the effect of reducing Cholesterol, weight loss, lower visceral fat function.

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and / or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive impairment, decreased libido, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.