The invention discloses preparation and application of an MOF-supported bimetallic catalyst, and belongs to the technical field of catalysts. The preparation method of the catalyst comprises the following steps: 1) firstly, dispersing an MOF carrier in a hydrophobic solvent, then dropwise adding an aqueous solution of a first metal salt, carrying out ultrasonic stirring, then drying a product, andfinally reducing the dried product to reduce first metal salt ions into first metal; and 2) dispersing the product reduced in the step 1) in an organic solvent, adding a second metal organic salt inan inert atmosphere, stirring the solution, separating the obtained product, and washing and drying the product to obtain the MOF supported bimetallic catalyst. The MOF supported bimetallic catalyst is applied to CO2 hydrogenation to prepare methanol. Compared with a traditional Cu / ZnO catalyst, the catalyst has the advantages that under the same catalytic condition, the selectivity to methanol ishigher than 80%, the conversion rate is high, and the stability is greatly improved.