The present invention belongs to the technical field of tobacco breeding, and particularly relates to a flue cured tobacco anti-black shank disease variety oriented cultivation method, which comprises the following main breeding process: germplasm resource screening, parent strain selective pairing, F1 disease nursery identification, F2-3 generation disease nursery screening, F4-6 field identification, strain identification, strain comparison test, regional test, production test, and variety validation, and comprises: 1, selective pairing and hybridization of excellent complementary parent strain materials, wherein excellent complementary parent strain materials are screened from anti-black shank disease, high-yield and high-quality germplasm resource materials and are subjected to hybridization; 2, oriented cultivation, wherein the new strain with advantages of strong black shank disease resistance, strong drought resistance and high yield is selected. According to the present invention, the bred new flue cured tobacco anti-black shank disease variety has characteristics of significant black shank disease resistance, high yield potential, good quality and the like, such that the disease identification time at the late stage is saved, and the cultivation efficiency of the anti-black shank disease variety is improved.