The invention discloses a process for synthesizing diacetylmonoxime ethyl
ether by continuous reactions in a microtube. In the process, diacetylmonoxime and
diethyl sulfate are directly reacted to synthesize diacetylmonoxime ethyl
ether in a condition that the temperature is 30-45 DEG C and the pressure is 0.1MPa in the presence of strong base with the adoption of a
continuous reaction technology in the microtube, wherein the strong base is
sodium hydroxide,
potassium hydroxide or an alcamine compound. In the process,
diethyl sulfate, the alkali liquor and diacetylmonoxime are respectively fed by a precise
micro pump, wherein diacetylmonoxime sequentially mixed with the alkali liquor and
diethyl sulfate reacts in a microtube reactor. The product through a
heat exchanger is condensed and collected at low temperature, and is stewed and layered by a chromatographic separator. A water phase is extracted and separated by a micro extraction
tower, and an
oil phase containing diacetylmonoxime ethyl
ether is rectified and purified by a rectifying
tower, so that the final product diacetylmonoxime ethyl ether is obtained. The process is high in selectivity of diacetylmonoxime ethyl ether,
mass transfer and
heat transfer can be remarkably enhanced, and
hydrolysis of diethyl
sulfate is effectively avoided. The process is simple in process, long in stable transfer time, low in cost, easy to amplify and suitable for the industrialized production requirement.