The invention discloses a manufacturing method of a high-strength LED (light-emitting diode) glass bulb. The manufacturing method comprises the following steps: (1) preheating the LED glass bulb which is washed cleanly to the temperature of 350 DEG C, and performing heat preservation for 0.5h; (2) preparing mixed molten salt, heating to the temperature of 400-480 DEG C, performing the heat preservation for 1-3h, then immersing the LED glass bulb into the mixed molten salt with the temperature of 400-480 DEG C, soaking for heat preservation for 5-8h; and (3) after soaking, taking the LED glass bulb out of the mixed molten salt, annealing to room temperature, and washing to finally obtain the high-strength LED glass bulb, wherein the mixed molten salt is formed by mixing a potassium nitrate molten salt serving as a main raw material with additives including potassium hydroxide, potassium fluoride, aluminum oxide and diatomite. According to the manufacturing method disclosed by the invention, by adopting the mixed molten salt based on optimized proportion, the speed and the depth of ion exchange are improved, the surface compression stress of glass is increased, and the strength, the impact resistance and the thermal stability of the LED glass bulb are further improved.