The invention discloses an automatic exposure machine mechanism, which comprises a frame, a lower frame lifting mechanism, a frame change mechanism and a lifting alignment device, wherein the frame is used for clamping a negative film and a substrate in the up-down direction; the frame is divided into a lower frame and an upper frame, which are arranged at the left side and the right side; the lower frame lifting mechanism is arranged at the bottom end of the lower frame and is used for controlling lifting of the lower frame to the same height as the upper frame; the frame change mechanism is used for exchanging the positions of the upper frame and the lower frame in the left-right direction; and the lifting alignment device is arranged below the lower frame and is used for adjusting the position, relative to the upper negative film, of the lower substrate. The automatic exposure machine mechanism is simple in structure, good in stability and high in exposure accuracy. The lower frame is provided with the lower frame lifting mechanism, so that the condition that an industrial camera does not generate an error due to a focusing problem of the lower stage frame when collecting an image is ensured; the lifting alignment device can adjust the position, relative to the negative film, of the lower substrate, so that accurate alignment is achieved; the upper frame and the lower frame are subjected to left and right position exchange through the frame change mechanism; the automatic exposure machine mechanism is simple to run and convenient to operate; an exposure machine can stably run; and the work efficiency is also improved.