The invention discloses high-performance concrete with a large mixing amount of mineral powder and a manufacturing method of the high-performance concrete. The high-performance concrete is manufactured from cement, slag powder, coal ash, crushed stone, river sand, water, an exciting agent, and a water reducer, and comprises, by weight part: 140-170 parts of cement, 170-240 parts of slag powder, 50-100 parts of coal ash, 1010-1100 parts of crushed stone, 735-825 parts of river sand, 150-180 parts of water, 11-15 parts of an exciting agent, and 3.4-5 parts of a water reducer. Slag powder and coal ash are re-mixed into the concrete as a supplementary cementitious material, through an exciting effect of the sodium sulfate exciting agent, to manufacture the high-performance concrete with a large mixing amount of mineral powder. Long-term strength, durability, and working performance of the cement concrete are effectively improved. A large amount of industrial waste, such as mineral powder and coal ash, is utilized in the formula, thereby reducing cement consumption in pre-mixed concrete. The cost is reduced, and the method is energy-saving and eco-friendly.