43results about How to "Efficiently introduced" patented technology

An assembly to be detachably mounted on a body fluid monitoring system is provided. The assembly has a lancet and a device for collecting and detecting a body fluid. The lancet has a puncture needle. In this assembly, the puncture needle is maintained in sterilized conditions until its use, and the sterilization can be conducted with no adverse effects on the detection device. A readily sterilizable lancet unit and a body fluid-collecting and detecting unit adapted for use in such an assembly as well as a body fluid-monitoring system including such an assembly are also provided. The assembly comprises a first housing having a sleeve which movably accommodates the lancet in its interior, and a second housing having the body fluid detection device. The first housing and the second housing share an opening. The lancet is sterilized before the assembly. The body fluid-collecting and detecting section has a body fluid guide on the periphery of the inlet.

A method for producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest; and 2) a viral capsid or envelope carrying a member of a specific binding pair, the counterpart of which is not directly associated with the surface of the target cell. These vehicles can be rendered unable to bind to their natural cell receptor. The targeting conjugates include the counterpart member of the specific binding pair, linked to a targeting moiety which is a cell-type specific ligand (or fragments thereof). The number of the specific binding pair present on the viral vehicles can be, for example, an immunoglobulin binding moiety (e.g., capable of binding to a Fc fragment, protein A, protein G, FcR or an anti-Ig antibody), or biotin, avidin or streptavidin. The virus' outer membrane or capsid may contain a substance which mediates entrance of the gene delivery vehicle into the target cell. Due to the specificity of the ligand, the binding pair's high affinity, and the gene delivery vehicle's inability to be targeted when used alone, the universality of the method for gene delivery, together with its high cell type selectively can be achieved by using various targeting conjugates.

Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a genetic disease in an individual in need thereof. Further disclosed are chimeric restriction endonucleases.

An area light source comprising an LED primary light source (2), a plate-like light guide (4) and a light deflector (6) is provided with a direct light incoming prevention means closed of a light-blocking member (9). The light guide (4) has a light incoming end face (41) and a light outgoing face (43) and guides a light emitted from the LED primary light source (2). The light deflector (6) is arranged adjacently to the light outgoing face (43) and has a light entering face (61) and a light exiting face (62). The direct light incoming prevention means prevents a light, which is emitted from the LED primary light source (2), from entering into the light deflector (6) without passing through the light guide (4). The light-blocking deflector (9) is disposed on a first region of the light outgoing face (43) which is located near the edge of the light incoming end face side of the light outgoing face (4). The surface of the light-blocking member (9) facing the light outgoing face (43) is a diffusing reflective surface. The light deflector (6) is disposed on a second region of the light outgoing face (43) where the light-blocking member (9) is not arranged.

An electro-optical device includes a transparent substrate, a PIN type diode formed in the transparent substrate and receiving light introduced through a light receiving side surface of the transparent substrate, and a reflecting portion provided on a surface side opposite to the light receiving side surface of the transparent substrate and for reflecting light passed through the transparent substrate to the PIN type diode.

The present invention provides a high-voltage semiconductor device including a deep well, a first doped region disposed in the deep well, a high-voltage well, a second doped region disposed in the high-voltage well, a first gate structure disposed on the high-voltage well between the second doped region and the first doped region, a doped channel region disposed in the high-voltage region and in contact with the second doped region and the deep well, and a third doped region disposed in the high-voltage well. The high-voltage well has a first conductive type, and the deep well, the first doped region, the second doped region, the doped channel region, and the third doped region have a second conductive type different from the first conductive type.

An internal combustion engine includes: a main combustion chamber; an intake port connected to the main combustion chamber at an intake opening; an exhaust port connected to the main combustion chamber at an exhaust opening; a sub-chamber provided between the intake opening and the exhaust opening, and connected to the main combustion chamber through a plurality of through-holes; a fuel injector injecting fuel into the sub-chamber; and a spark plug performing ignition in the sub-chamber. A tumble flow flows from a first side to a second side as seen from the sub-chamber. The through-holes include: a first through-hole formed in a first side part of a side wall of the sub-chamber; and a second through-hole different from the first through-hole. A diameter of the first through-hole is larger than that of the second through-hole.

A toilet tool cleansing system employs a mixing eductor that disperses a disinfectant solution into a water stream that is sprayed onto the tool and thereafter collected and discharged into a toilet via a drain eductor. The cleansing system includes plumbing and a valve adapted to be in fluid communication with an existing water supply source. A housing receives the toilet tool. The housing has at least one spray nozzle in fluid communication with the mixing eductor for dispensing the water and disinfectant on the tool. The drain eductor propels waste liquids from the system into a toilet bowl.

The invention relates to a rotor (13) for a turbo machine, in particular for an aircraft turbine, having rotating blades (12), which are joined to a basic rotor body (14), in which at least one rotating blade (12) has at least one inner cooling channel, which extends at least along a predominant region of a blade element (18) of rotating blade (12) and has an inlet opening (23) for introducing cooling air into blade element (18), in which the inlet opening (23) is formed in a blade neck (16) lying between a blade foot (32) and a blade platform (10) of rotating blade (12). Inlet opening (23) is disposed in a cavity (22) formed radially underneath blade platform (10). In addition, the invention relates to a blade or vane, in particular a rotating blade (12) for a rotor (13) of a turbo machine, as well as a turbo machine.

The present invention provides a method for Agrobacterium-mediated gene introduction into a plant material, comprising: 1) treating the plant material, and then

• 2) infecting the plant material with an Agrobacterium, characterized in that a medium enriched in a metal salt containing copper ion is used in step 1) and/or 2). The present invention also provides a process for preparing a transformed plant characterized in that the gene introduction method of the present invention is used.

Actuator having a drive element (16) which can be driven in reaction to electrical operation of a coil device (14), said drive element consisting of a magnetic shape-memory material and being designed to transmit mechanical drive energy to an actuating partner (28), wherein the drive element, which is in the form of an expansion unit (16) and is aligned such that it extends in a drive direction (22), is associated with a pair of laterally adjacent magnetic flux guide elements (18, 20) for a magnetic flux produced by the coil device, such that the magnetic flux is guided between the flux guide elements through the expansion unit and transversely with respect to the drive direction, the coil device (14) being provided such that it is circumferential around the expansion unit (16) which extends axially in the drive direction.

In a rotor of a rotary-electric machine, in order to improve a cooling performance of a rotor winding, in a rotor winding on an end portion of the rotor in an axial direction, the rotor winding being held by a retaining ring of the rotor winding formed by laminating a plurality of conductors in slots of a rotor iron core extending in an axial direction and having a plurality of slots formed at predetermined intervals in a peripheral direction, ventilation channels through which cooling air flows are formed in the surfaces of the conductors along a longitudinal direction. The ventilation channels have air inlet holes which guide the cooling air and exhaust holes which exhaust the cooling air, the conductors provided with the ventilation channels which are formed in the surfaces of the conductors along the longitudinal direction and through which the cooling air flows are laminated to constitute the rotor winding, and the conductors include openings of the air inlet holes in bottoms of the conductors on a side opposite to a side on which the ventilation channels are formed.

Suggested is a method for engineering and/or editing the genome of prokaryotes encompassing the following steps: (i) providing a culture of prokaryotic cells, (ii) preparing a vector comprising an expression system encompassing at least one programmable DNA-binding and -cleaving protein, (iii) introducing said vector into said prokaryotic cells to target a specific DNA sequence in the genome of said prokaryotic cells.

The present invention relates to the use of inclusion bodies as vehicles for therapeutic protein delivery. This method is applicable to the delivery of therapeutic proteins to intracellular locations. In addition, the invention also relates to the administration of a cell or a pharmaceutical composition comprising inclusion bodies formed by therapeutic proteins. These inclusion bodies formed by therapeutic proteins could be used for the treatment of different diseases.

The present invention is a planar antenna member configured to introduce electromagnetic waves generated by an electromagnetic-wave generating source into a processing vessel of a plasma processing apparatus, the planar antenna member comprising: a base member of a circular plate shape, made of a conductive material; and a plurality of through-holes formed in the base member of a circular plate shape, the through-holes being configured to radiate the electromagnetic waves; wherein: the through-holes include a plurality of first through-holes which are arranged on a circumference of a circle whose center corresponds to a center of the planar antenna member, and a plurality of second through-holes which are arranged concentrically with the circle outside the first through-holes; a ratio L1/r is within a range between 0.35 and 0.5, in which L1 is a distance from the center of the planar antenna member to a center of one of the first through-holes, and r is a radius of the planar antenna member; and a ratio L2/r is within a range between 0.7 and 0.85, in which L2 is a distance from the center of the planar antenna member to a center of one of the second through-holes, and r is the radius of the planar antenna member.