The invention relates to a formula of a health-care wine, which is prepared from the following raw materials by weight: 20 to 60g of Chinese angelica, 20 to 60g of white paeony root, 20 to 60g of rehmanniae praeparatum, 20 to 60g of twotooth achyranthes root, 20 to 60g of Amur corktree bark, 20 to 60g of eucommia bark, 20 to 60g of divaricate saposhnikovia root, 20 to 60g of dahurian angelica root, 10 to 50g of Szechuan lovage rhizome, 10 to 50g of incised notopterygium rhizome, 10 to 50g of doubleteeth pubescent angilica root, 10 to 30g of areca seed, 5 to 20g of cassia bark, 5 to 20g of mix-fried licorice root and 1,000 to 2,000g of white wine. The method for preparing the formula comprises the following steps: (1), frying the white paeony root; (2) frying the Amur corktree bark with salt; (3) frying the eucommia bark with ginger; (4) crushing the medicaments, and putting the mixture into a silk bag; (5) pouring the white wine, storing the mixture into an urn, boiling the mixture on the fire for 1 hour; and (6) deslagging to obtain the health-care wine. The health-care wine has the effects of enhancing immunity, resisting aging, improving five primary elements of human body internal organs such as heart, liver, spleen and lung, quickening the blood and relieving pain, dispelling wind and eliminating dampness, supplementing kidney and quieting spirit, and the like. The health-care wine has the advantages of brownish red and transparent color, mellow and slightly bitter taste, pure and mild flavor and lingering aftertaste, can be used as an edible beverage, and can also be used as a medicament for healing and treating.