34 results about "Vidarabine Monophosphate" patented technology

The invention discloses a method for preparing vidarabine monophosphate for injection, which comprises the following steps of: dissolving vidarabine monophosphate into a solvent with heating, adding a proper amount of excipient and active carbon into the solution, filtering the solution to remove carbon, filtering the solution through a micropore filtration membrane, canning the filtrate into a tubular furbenicillin bottle, and putting the furbenicillin bottle into a freeze drier to perform freeze drying. The method is easy for industrialized production, solves the problem of vidarabine monophosphate freeze drying preparation, and ensures stable product quality.

The invention discloses a refining method of vidarabine monophosphate. The refining method is characterized by comprising the following steps of: regulating the pH of a vidarabine monophosphate crude product and an antioxidant to 8-10 by using alkali, and heating and dissolving; then adding a right amount of active carbon, and filtering while hot; regulating pH to 3-5; and crystallizing. The refining method disclosed by the invention can achieve high yield and can be used for refining the high-purity vidarabine monophosphate.

The invention relates to an officinal composition of vidarabine monophosphate for injection, wherein the main active components of the composition comprise vidarabine monophosphate and lysine.

The invention discloses a preparation method of a vidarabine monophosphate freeze-dried powder injection for injection. The preparation method comprises the steps as follows: taking vidarabine monophosphate, sodium bicarbonate and injection water as raw materials; preparing the raw materials into a vidarabine monophosphate drug solution; canning the drug solution and pressing by half; freezing and drying; pressing; re-pressing; and unpacking to obtain the vidarabine monophosphate freeze-dried powder injection. An excipient or a similar sodium hydroxide strong base solution is not adopted in the adopted vidarabine monophosphate drug solution, so that the influence of the excipient or the similar sodium hydroxide strong base solution on the quality of the vidarabine monophosphate freeze-dried powder injection in the prior art is avoided, the influence of the excipient or the similar sodium hydroxide strong base solution on the vidarabine monophosphate freeze-dried powder injection is effectively reduced, and the quality of drugs is better guaranteed. The vidarabine monophosphate freeze-dried powder injection is better in re-solubility, good in formability and appearance, full and glossy.

The invention discloses vidarabine monophosphate for injection and a method for producing the vidarabine monophosphate. The vidarabine monophosphate for the injection comprises 100.0g of the vidarabine monophosphate, 50.0g of mannitol, 5.0g of medicinal carbon, and 2000ml of water for the injection. The method sequentially comprises the following steps: (1) washing, drying and disinfecting a bottle, (2) washing and disinfecting a plug, (3) conducting preparation, (4) conducting filling, (5) conducting freeze drying, (6) rolling a cover, (7) conducting light inspection, and (8) conducting lettering, packaging and storage. Compared with the prior art, the vidarabine monophosphate produced by the method is good in crystal form, simple in step and short in cycle, and the production efficiency is improved.

The invention belongs to the technical field of preparation of vidarabine monophosphate and particularly relates to a production process of vidarabine monophosphate. The production process of vidarabine monophosphate comprises the following steps of S1 dissolving vidarabine into organic solvent and cooling down the mixture; S2, adding in phosphoryl chloride to perform thermal reaction until that the residual content of the vidarabine is not higher than 3% of the added amount; S3, adding in palladium catalysts for catalytic reduction, then filtering reaction products, removing the solvent fromthe obtained filter liquor to obtain crude vidarabine monophosphate; S4, recrystallizing the crude vidarabine monophosphate obtained in S3 for purification. The production process of vidarabine monophosphate introduces the phosphoryl chloride relatively low in reactivity to react with the raw vidarabine, the reaction process is mild and easy to control, so that the produced quantity of side products can be reduced from the source; meanwhile, the novel palladium catalysts can selectively reduce introduced ether groups, thereby simplifying purification processes and achieving high product yieldand purity.

The invention provides a vidarabine monophosphate injection and a preparation method thereof. The injection is prepared from the following raw materials by weight: 50-200 parts of vidarabine monophosphate, 0.015-0.05 part of a pH regulator and 2000 parts of water for injection. A finished product prepared by the method provided by the invention has low impurity content, good homogeneity and good stability. A water injection is subjected to terminal sterilization to ensure the safety of the product. The water injection is convenient to use, and does not need to be prepared before clinical application, so as to reduce the potential safety hazard caused by operation and provide a new choice of medication for clinical use.

The invention relates to a vidarabine monophosphate pharmaceutical composition and a preparation method thereof. A low dose of the vidarabine monophosphate pharmaceutical composition is effective in treating herpesvirus infection or cytomegalovirus infection in children 0 to 14 years old, and the toxic and side effect and the increase in medical cost caused by a high-dose or ultrahigh-dose administering manner of 5-10 mg/kg reported in documents are avoided.

The invention provides a preparation method of vidarabine monophosphate freeze-dried powder injection for injection, which belongs to the technical field of medicine preparation, and comprises the following steps: taking water for injection, adjusting the pH value to 8.0-8.5, adding vidarabine monophosphate for dissolving, decoloring, degerming, filtering, sub-packaging, pre-freezing the obtained feed liquid, sublimating and drying for four times, desorbing and drying for three times, and obtaining the vidarabine monophosphate freeze-dried powder injection for injection. By adjusting the pH value, the hydrolysis reaction of vidarabine monophosphate is reduced, and the impurity content of the finished product is reduced; through setting of technological parameters in the sublimation drying process and the desorption drying process, solute migration in liquid medicine is prevented, fullness and looseness of the finished product are guaranteed, and the surface of the finished product is smoother. The preparation method provided by the invention can effectively improve the drug stability, appearance shape and looseness of the finished product.

The invention belongs to the field of medicine synthesis, and discloses a synthesis method and application of vidarabine monophosphate. According to the synthesis method, 5-iodo-2-((phosphonooxy) methyl)-4-(tosyloxy)tetrahydrofuran-3-yl acetate and tert-butyl (8-hydroxy-9H-purin-6-yl)carbamate are subjected to condensation, epoxidation, ring opening and desulfurization reaction, and the vidarabine monophosphate is synthesized. According to the synthesis method of vidarabine monophosphate, provided by the invention, the industrial production steps are further simplified, the total reaction yield is improved, and the industrial production cost is reduced. The method is suitable for synthesizing vidarabine monophosphate, and the synthesized vidarabine monophosphate is used for preparing vidarabine monophosphate for injection.