47 results about "Vaccine administration" patented technology

The invention relates to vaccine compositions having a carrier protein and an antigen of interest entrapped in a complex, methods of making such vaccines, and methods of vaccine administration.

The inventors have discovered that a CKbeta8-1 truncation variant, CKbeta8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKbeta8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKbeta8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKbeta8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.

The invention relates to vaccine compositions having a carrier protein and an antigen of interest entrapped in a complex, methods of making such vaccines, and methods of vaccine administration.

The present invention relates to immunogenic compositions containing an antigen of interest entrapped with a crosslinked carrier protein matrix, methods of making such vaccines, and methods of vaccine administration, wherein the immunogenicity of the protein matrix, and hence its effectiveness as a vaccine, is improved by controlling or selecting the particle size of the protein matrix particles to eliminate low molecular weight particles, e.g., less than 100 nm in diameter.

The invention relates to a vaccine management system and method, a terminal device and a storage medium, and the system comprises a vaccine management module which comprises a vaccine information storage sub-module, wherein the vaccine information storage sub-module stores the related information of a vaccine, and manages the vaccination of the vaccine according to the related information of the vaccine; a vaccine inoculation module which is used for determining whether the vaccine meets a preset inoculation condition or not according to the vaccine related information sent by the vaccine management module, outputting first alarm information when the vaccine does not meet the preset inoculation condition, and querying vaccine-related information; and a vaccine refrigeration module which isused for refrigerating the vaccine, acquiring and displaying related information of the vaccine, and outputting second alarm information under the condition that the vaccine does not meet a preset inoculation condition. According to the invention, the vaccination is intelligently managed, so the vaccination errors caused by vaccine expiration and the like are avoided, and the vaccination safety is guaranteed.

The invention discloses a method for preparing a polygalacturonic acid-based nano oral protein drug delivery system and application thereof. The system is prepared by adopting a W / O / W double emulsion method. The method comprises the following steps: dissolving polygalacturonic acid in a 4-6w / v% poloxamer 188 solution, and adding bovine insulin for dissolving, thereby obtaining an inner water phase; taking ethyl acetate as an oil phase, respectively taking 18-22w / v% poloxamer 188 solution, 18-22w / v% poloxamer 188 solution dissolved with chitosan and 18-22w / v% poloxamer 188 solution dissolved with chitosan and genipin as outer water phase solutions, and preparing to obtain different nano oral protein drug delivery systems. The nano oral protein drug delivery system disclosed by the invention is non-toxic, easy to degrade, high in delivery rate and high in absorption rate, and has high application prospects in the fields such as delivery research and application of oral protein drugs such as insulin, diabetes treatment, and vaccine administration.

The invention discloses an intelligent vaccine management device and a control sytem thereof. The intelligent vaccine management device comprises a first fixing frame, a control cabinet is arranged onone side of the first fixing frame, a freezing cabinet is arranged below the control cabinet, and two refrigeration cabinets are distributed on the side, away from the first fixing frame, of the control cabinet in an array mode; The control cabinet is electrically connected with the freezing cabinet and the two refrigerated cabinets; the control cabinet monitors the temperatures and temperature early warnings of the freezing cabinet and the two refrigeration cabinets in real time; meanwhile, the control cabinet records the vaccine states of the freezing cabinet and the two refrigeration cabinets in real time and uploads the vaccine states to the Internet cloud end, and the Internet cloud end is connected with a user system and pairing corresponding information, so that information tracingof a user and an injector is realized.

The invention provides a vaccine management, transfer and inoculating device and method. The vaccine management, transfer and inoculating device comprises a cabinet body used for storing vaccine medicines in a preset temperature range, a display screen, a main control module, a scanning module, a plurality of vaccine storage drawers used for storing the vaccine medicines and an electric control lock module used for locking / unlocking the vaccine storage drawers, wherein a moving component used for moving the cabinet body is arranged at the bottom of the cabinet body, the display screen, a codescanning module and the vaccine storage drawers are arranged on the cabinet body, the main control module and the electric control lock module are arranged in the cabinet body, and the main control module is electrically connected with the display screen, the scanning module and the electric control lock module. The vaccine management, transfer and inoculating device and method are mainly used forovercoming the defects of an existing intelligent vaccine management machine, and aims to build an information management internet-of-things bridge between the intelligent vaccine management machineand a plurality of inoculation points, so that medical workers do not need to transfer vaccines to an inpatient area in a short distance by using a simple thermal insulation box for inoculation.

The invention belongs to the technical field of vaccine management, and discloses a method for constructing a credible vaccine traceability system based on a block chain technology, which adopts an alliance chain architecture and adopts a group and node combined mixed mode, and a business architecture, a hardware architecture, a software architecture and a data docking interface scheme are determined to construct the trusted vaccine traceability system based on the block chain technology. Based on the block chain and credible traceability technology, all related parties in the processes of vaccine examination and approval, production, circulation, inoculation and the like can be linked, information of each transaction link is tracked and recorded in the whole process, a combined code is formed by a vaccine identification code, a cold chain equipment code, an audience code, an inoculation unit code and an inoculation doctor code, and the information of each transaction link is tracked and recorded in the whole process. And a traceable safe inoculation credit system is constructed. According to the construction of the block chain + vaccine credible tracing system, the source is reliable, tampering-free, whole-course supervision, human and vaccine association, code scanning inoculation and credible tracing are realized, and guarantee is provided for public health.

The invention relates to vaccine compositions having a carrier protein and an antigen of interest entrapped in a complex, methods of making such vaccines, and methods of vaccine administration.

The anti-pathogen vaccine of the present invention is produced in recombinant bacteria and / or transgenic plants and then administered through standard vaccine introduction method or through the oral administration. A DNA sequence encoding for the expression of an antigen of a pathogen is isolated and ligated to a promoter which can regulate the production of the surface antigen in a bacterial or transgenic plant. Preferably, a foreign gene is expressed in a portion of the plant or bacteria, and all or part of the antigen expressing plant or bacteria used for vaccine administration. In a preferred procedure, the vaccine is administered through the consumption of the edible plant as food, or the bacteria administered orally. The present invention also provides a method of using genetically modified microorganisms generally recognized to be edible and / or harmless to animals or humans when ingested, such as lactic acid bacteria, including Lactococcus lactis strains, as oral vaccines. In one embodiment, Lactococcus lactis expressing the avian influenza HA gene can be used as an oral vaccine for protection against H5N1 virus infection.

The invention provides an information reporting method and device based on AI and RPA, equipment and a medium, and relates to the field of AI and RPA, and the method comprises the steps: recognizing the certificate information of a vaccination person through an OCR technology, and obtaining the personal information of the vaccination person; comparing the personal information of the vaccination personnel with the personal information of each reservation personnel in the reservation vaccination data to determine whether the vaccination personnel is the reservation personnel; recording personal information of the vaccination personnel and corresponding vaccination information under the condition that the vaccination personnel are reserved personnel; and controlling the RPA robot to report the personal information of the vaccination personnel and the corresponding vaccination information to a vaccine management system. Therefore, the personal information of the vaccination personnel and the corresponding vaccination information are automatically reported to the vaccine management system through the RPA robot, so that the burden of workers can be reduced, the information reporting efficiency can be improved, and the situation of manual input errors is avoided.

The embodiment of the invention provides a smart city vaccine scheduling method and system based on the Internet of Things, the method is executed by a city vaccine management platform, and the method comprises the following steps: obtaining a service range corresponding to each vaccination point in a preset area; obtaining vaccine service related information of the service range, wherein the vaccine service related information comprises vaccination information, target vaccination personnel information and the time type of each preset time point; and performing prediction based on the vaccine service related information of the service range, and determining a prediction result. The prediction result comprises the number of possible vaccination people at each vaccination point at each preset time point; and determining a vaccine distribution scheme based on the prediction result.

The invention relates to a vaccine identification management system. The vaccine identification management system comprises a vaccine cabinet, a background server and a remote monitoring terminal, wherein the vaccine cabinet and the remote monitoring terminal are connected with the background server, and the vaccine cabinet is connected with the remote monitoring terminal. The vaccine cabinet is provided with a face recognition module, a fingerprint recognition module, a bar code recognition module, a wireless communication module and a processor. The face recognition module, the fingerprint recognition module, the bar code recognition module and the wireless communication module are connected with the processor. The face recognition module is used for recognizing facial features of a to-be-inoculated person; the fingerprint identification module is used for identifying fingerprints of medical staff; the bar code recognition module is used for recognizing bar codes, belonging to to to-be-inoculated people, on the inoculation book. Vaccine management is changed from manual operation to automation, the low-temperature storage quality of vaccines can be ensured, the vaccine distribution efficiency is improved, and the error rate in the vaccine distribution process is reduced.

The present invention relates to immunogenic compositions containing one or more antigens of interest, one or more carrier proteins, and one or more polycations, wherein the antigen of interest is entrapped with cross-linked carrier protein matrix and one or more polycations, methods of making such vaccines, and methods of vaccine administration.

The invention discloses a vaccine management method based on a block chain. The block chain is composed of a plurality of block nodes, each block node is divided into a main block and an auxiliary block, the main blocks and the auxiliary blocks are in one-to-one correspondence, the method comprises the steps that first vaccine information of all vaccines of a current node is stored in the auxiliary blocks, and the first vaccine information at least comprises temperature record information of the vaccines; obtaining temperature qualification results of all vaccines according to the temperaturerecord information; and mapping the temperature qualification result obtained in the auxiliary block to the main block, storing second vaccine information of all vaccines of the current node in the main block, and uploading the main block to a block chain, the second vaccine information at least comprising a vaccine traceability code and a temperature qualification result of the current node. According to the invention, excessive data redundancy of the block chain is avoided, and the operation efficiency of the block chain is improved.

This invention relates to the field of vaccine management and, in particular to a system and method for reserving a dose of influenza vaccine. The system for reserving a flu-shot comprises a user interface and a matching node. The method comprises receiving a flu shot reservation from a user and matching the reservation to a health care provider.

The present invention relates to immunogenic compositions containing one or more antigens of interest, one or more carrier proteins, and one or more polycations, wherein the antigen of interest is entrapped with cross-linked carrier protein matrix and one or more polycations, methods of making such vaccines, and methods of vaccine administration.

The invention discloses a vaccine inventory method, a device and a system, and the method comprises the steps: enabling a vaccine inventory device to send an unlocking instruction to vaccine storage equipment, and scanning a vaccine supervision code to obtain vaccine supervision code scanning data; when the vaccine supervision code scanning data does not accord with the account vaccine data, modifying the account vaccine data; and sending the modified data to the vaccine management platform, so that the vaccine management platform updates the account vaccine data. According to the method, vaccine warehousing and inoculation recording are carried out by using a computer at present; the vaccine inventory device is used for controlling the vaccine storage equipment to be unlocked; scanning the vaccines one by one to obtain vaccine supervision code scanning data and displaying the vaccine supervision code scanning data; when vaccine checking is carried out, a worker can modify vaccine datawith errors, the vaccine management platform updates account surface vaccine data, it is guaranteed that account surface vaccines accord with actual vaccines, correct checking of the vaccines is achieved, and the technical problem that recording is inaccurate when a computer is used for vaccine checking at present is solved.

Described are cell-based cancer vaccines and anti-cancer immunotherapies. The vaccines include isolated tumor cells activated with one or more genotoxic drugs, and, optionally, treated with one or more MK2 inhibitors. The activated cells are highly immunogenic non-proliferative cells, and may be tested for immunogenicity ex vivo for priming T cells by co-incubating the isolated activated cells with dendritic cells and T cells. The vaccines are typically administered into patient's tumor to provide an intratumoral immune activation. Immune checkpoint inhibitor(s) (ICI) may be administered before, during, or after vaccine administration. ICI may be a component of the vaccine. The vaccines confer heightened cytotoxic immune response against the cancer cells, induce tumor regression, and enhance survival from cancer. The vaccines prevent tumor recurrence and induce a long-lasting anti-tumor immunological memory.

The invention discloses an ecological vaccine management device and method based on a block chain. The method comprises the following steps: acquiring vaccine circulation data of any transmission point, wherein the transmission points are a production transmission point, a logistics transmission point, a detection point, an inoculation point and a recovery point; sending the vaccine circulation data to a block chain management network for verification, and receiving a verification result returned by the block chain management network; if the verification result is passed, uploading vaccine circulation data to each block chain node of the block chain management network, wherein the transmission data of the transmission point at least comprises character string data formed by combining operators and vaccine data, and the vaccine circulation data is sent to a block chain management network for verification, including matching data verification and time verification. By means of the mode,the vaccine circulation process can be monitored and traced, and vaccine control and safety are improved.

The invention provides an intelligent vaccine management system and method. The system comprises an on-site management system which comprises a local server, a communication module and a terminal node arranged on a vaccine use site, wherein data information collected by information collection equipment is sent to a cloud server through network communication to be stored and processed, a control instruction generated by the cloud server is sent to the local server, and the local server controls execution equipment to act; the cloud server; a control system which is in communication connection with the on-site management system and the cloud server; and a vaccine storage box and a vaccine inoculation box. According to the invention, on one hand, full-process tracing of vaccination is realized, and the safety of a recipient is ensured; and on the other hand, the intelligent visual warehouse-in and warehouse-out management system can greatly improve the vaccination efficiency, simplify the manual operation process, effectively ensure the vaccine safety and improve the vaccine utilization rate.

A vaccine administration reminding method includes the steps of providing a vaccination reminder message to a user of a mobile device according to a vaccine administration receiver's birth date, displaying a list of potential hospitals according to a user behavior of the user on the mobile device, and recording a vaccination hospital selected by the user from the list. The user behavior may include browsing a web page of the vaccination hospital on the mobile device or dialing a telephone number of the vaccination hospital on the mobile device.

The invention discloses a vaccine management method and system based on an electronic supervision code, and the method comprises the steps: in a vaccine storage process, recognizing the vaccine electronic supervision code through a vaccination scanning terminal, and receiving vaccine anti-counterfeiting verification information returned by a vaccine management database; comparing whether the vaccine anti-counterfeiting verification information is consistent with the corresponding vaccine basic information in the storage record, if so, recording and prompting a normal vaccine state, and updating the information to a vaccine management application system; in the vaccination process, the vaccination electronic supervision code is recognized through a vaccination scanning terminal, and basic vaccine information returned by the vaccine management database is confirmed and uploaded to a vaccination application system; and displaying vaccine information for confirmation of the recipient through the vaccination application system, and uploading the information of the recipient to a vaccine management database to be associated with vaccine anti-counterfeiting verification information marked by the vaccine electronic supervision code. And full information supervision on vaccine use and storage is realized.

A vaccine administration reminding method includes the steps of providing a vaccination reminder message to a user of a mobile device according to a vaccine administration receiver's birth date, displaying a list of potential hospitals according to a user behavior of the user on the mobile device, and recording a vaccination hospital selected by the user from the list. The user behavior may include browsing a web page of the vaccination hospital on the mobile device or dialing a telephone number of the vaccination hospital on the mobile device.

A percutaneous vaccine delivery device (1) employing an acoustically induced micropore array. The device (1) comprises a main control system (11), a high-frequency intense-focused ultrasonic excitation assembly (12), and an acoustically permeable immunization patch (13). The high-frequency intense-focused ultrasonic excitation assembly (12) comprises a high-frequency ultrasonic signal generation system (121), a first ultrasonic transducer (122) connected to the high-frequency ultrasonic signal generation system (121), and a conical coupling duct (123) connected to the first ultrasonic transducer (122). The conical coupling duct (123) is placed on the acoustically permeable immunization patch (13) during vaccine administration, such that high-frequency intense-focused ultrasonic energy is output from a front end of the duct to induce formation of micropores and micropore arrays on the skin.