140 results about "Second pathway" patented technology

A method of treating pelvic organ prolapse is provided. The method generally includes the steps of establishing a first pathway between the external perirectal region of the patient to the region of the ischial spine in tissue on one side of the prolapsed organ, followed by establishing a second pathway in tissue on the contralateral side of the prolapsed organ. A support member, which includes a central support portion and two end portions, is positioned in a position to reposition said prolapsed organ in said organ's anatomically correct location. The end portions of the support member are introduced through the respective tissue pathways, followed by adjustment of the end portions so that the support member is located in a therapeutic relationship to the prolapsed organ that is to be supported. An apparatus and kit for said treatment is further provided.

This invention pertains to the identification of two novel epithelial signaling pathways in ER-positive breast cancer s and the discovery that the cellular biology and (likely also the clinical outcome) of ER-positive breast cancer cells is unexpectedly altered when these signaling pathways are activated. The first pathway pertains to the discovery that NF-κB activation and / or DNA binding is implicated in the etiology of ER-positive breast (and other) cancers. The second pathway involves ligand-independent quinine-mediated ER activation by posphorylation (e.g. on SER-118 and SER-167 residues of ER) and nuclear translocation of full-length (67 kDA) ER as well as the phorphorylating activation of a truncated and nuclear-localized ER variant (˜52 kDa).

A multi-channel modular device (10) processes between two fluid streams of different compositions. The device (10) includes a porous body (150) having a first plurality of feed-flow pathways (110) disposed in the body (150) for transporting a first stream (180). A pathway wall (114) surrounds each of the first plurality of feed-flow pathways (110) for processing the first stream (180) into a first composition (1852) and a second composition (1802). At least one feed-flow inlet (1101) is disposed in the body (150) for introducing the first stream (180) into the first plurality of feed-flow pathways (110). At least one feed-flow outlet (1102) is disposed in the body (150) for discharging the remaining first stream containing the second composition (1802). At least one second pathway (210) is disposed in the body (150) for transporting a second stream (280) having a second inlet (2101) and a second outlet (2102). A networked plurality of fluid conduits (152) formed in the porous body (150) provides the flow-conduit for the second stream (280) to sweep the first composition (1852) from each of the first plurality of the feed-flow pathways (110) to the second outlet (2102). A vessel (300) ports the inlets (1101 and 2101) and outlets (1102 and 2102) to provide a second stream flow access and for spacing the body within and away from the inner surfaces of the vessel (300) to provide a gap (310) for access. A partition (350) is disposed in the gap between the body and the vessel for diverting the flow within the gap (310).

A padded garment having at least one pocket with at least one pad located within the at least one pocket. The at least one pad has a plurality of interconnected, spaced apart tubes. A first end of each of the spaced apart tubes are interconnected along a first pathway and a second end of each of the spaced apart tubes are interconnected along a second pathway. The first and second pathways are recessed from a top plane and a bottom plane of the pad in areas between adjacent tubes such that the pad is flexible along the recessed areas of the first and second pathways and substantially less flexible along a length of the spaced apart tubes. The pad is shaped to correspond to an area of a wearer's body it is intended to cover.

The present invention relates to an implant 100 which comprises a plurality of electrically-conductive closed loops (300A, 300B, 300C, 300D; 120A, 120B, 120C, 120D each constituted from a plurality of loop portions such as struts (400, 500). The loops together form apertured walls of a cage with an interior volume, and the portions in any one said loop providing electrically-conductive pathways within which eddy currents are liable to be induced when the implant is subjected to an time-dependent external magnetic field, with each said loop comprising at least first and second said pathways. The implant is characterized in that the first and second pathways are arranged such that, in any particular magnetic field, the direction of the eddy current that would be induced in the second pathway is the reverse of the direction of the eddy current that would be induced in the first pathway, so as to mitigate the tendency of the implant to function in said magnetic field as a Faraday cage.

Methods for producing optical fibers along nonlinear paths include incorporating fluid bearings. An optical fiber is drawn from a preform along a first pathway, contacted with a region of fluid cushion of a fluid bearing, and redirected along a second pathway as the fiber is drawn across said region of fluid cushion.

A manifold for accessing blood from a human blood vessel is disclosed which comprises a first and a second pathway intersecting with each other at an angle, the first pathway being configured to be completed embedded in the human blood vessel with the second pathway leading toward outside of the human blood vessel wherein the manifold is substantially retained by the human blood vessel alone.

A suppressor for reducing muzzle blast and noise of firearms. The suppressor can include a baffle tube including a stack of baffle modules that are removably coupled to one another, and an optional blast baffle, end cap and end cap insert. The stack can be independently supported from both bullet entry and exit ends of the tube, with the stack under tension and the tube under compression. Two or more tubes of can be joined with one another at ends having corresponding sealing flanges, which also can center the tubes relative to one another. A blast baffle can separate pressurized gas into a first pathway through the baffle stack and a second pathway between the baffle modules and the baffle tube. The baffle tube and / or an expansion chamber tube can include a rearward end cap that is removable and replaceable with an over the barrel expansion tube.

A bit holder comprises a body defining at least one cavity. The cavity includes a first pathway for receiving a bit and a second pathway for holding a bit. The first and second pathways intersect to define an open area between the first pathway and the second pathway such that a bit can be rotated between the first pathway and to a locked position in second pathway. The first pathway is disposed at an angle relative to the second pathway. The bit is retained by an interference fit with the body. The holder may be releasably retained in a case using mating structures on the case and holder. In a method for retaining a bit in a holder, the bit is inserted into the holder along the first pathway. The bit is rotated through the open area to position the bit in the second pathway where it is held.

An apparatus and method for retrieving metal objects. The apparatus includes a housing with an inner part, with the housing having a first wall. The apparatus further includes a sleeve disposed within the housing, with the sleeve being constructed of a non-magnetic conduction material. A magnet is disposed within the sleeve, with the magnet having a north pole and a south pole. The apparatus further includes a container disposed within the sleeve, the container having a second wall. In the most preferred embodiment, the first wall defines a first pathway for magnetic lines of flux for the north pole of the magnet and wherein the second wall defines a second pathway for magnetic lines of flux for the south pole of the magnet so that a toroidal magnetic field is formed about the distal end of the sleeve.

A flexible polymeric container for storing and dispensing liquids includes a first sidewall and a second sidewall connected together to define a fluid chamber therebetween. The first sidewall and the second sidewall are constructed of a coextrusion structure. The first sidewall and the second sidewall each have an inner surface facing the fluid chamber and an opposed outer surface. A fitment is attached to an outer surface of one of the first sidewall or the second sidewall. The fitment has an opening therethrough which has an axis substantially perpendicular to the outer surface. A pattern of protuberances on the inner surface of one of the first sidewall or the second sidewall defines a plurality of pathways having at least a first pathway and a second pathway intersecting one another. The protuberances facilitate evacuation of liquid when portions of the first sidewall and the second sidewall interlock during evacuation.