38 results about "S-Adenosylhomocysteine" patented technology

Provided are methods of designing a putative inhibitor of a 5′-methylthioadenosine / S-adenosylhomocysteine nucleosidase. The methods comprise designing a chemically stable compound that resembles the charge and geometry of the 5′-methylthioadenosine / S-adenosylhomocysteine nucleosidase transition state. Also provided are methods of inhibiting 5′-methylthioadenosine / S-adenosylhomocysteine nucleosidases using the inhibitors found by the above methods.

This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective methylation of S-adenosyl-L-homocysteine is achieved. The process for the salt preparation is simple, efficient & reproducible on large scale. The new salts were found to be stable at accelerated temperature for minimum 3 months.

A medical application of S-adenosine homocysteine in preparing immunodepressant with high effect and low poison is disclosed.

The invention discloses a method for measuring the activity of transmethylase in real time and a kit. The method comprises two reactions carried out at the same time in a reaction system; according to the first reaction, in a buffer system where it is guaranteed that S-ademetionine is adopted as a methyl donor and the transmethylase has the biological activity, a sample containing the transmethylase (MT), the methyl donor and a corresponding substrate are added, or the S-ademetionine methyl donor and the corresponding substrate are directly added into the liquid sample containing the transmethylase, and a reaction is carried out so that an S-adellosyl homocysteine (SAH) product can be generated, wherein the substrate is receptor matter of methyl; according to the second reaction, an immunological method is adopted for detecting the content of SAH to determine the activity of the transmethylase in the reaction system. The biochemical reaction of MT catalysis and the immunoreactions for measuring the product SAH are carried out at the same time, the two processes are organically combined, and great significance is especially achieved on accurate measurement of SAH with extremely unstable molecularity.

The invention provides a preparation method of S-adenosyl homocysteine ​​artificial complete antigen, comprising the following steps: mixing S-adenosyl homocysteine ​​and di-tert-butyl dicarbonate to obtain a first The intermediate, the di-tert-butyl dicarbonate is used to protect the antigenic epitope in S-adenosyl homocysteine; the carrier protein is added to the first intermediate, and a second intermediate is obtained after the reaction and removing the di-tert-butyl dicarbonate in the second intermediate to obtain the S-adenosyl homocysteine ​​artificial complete antigen. The S-adenosyl homocysteine ​​artificial complete antigen prepared by the method has high specificity, selectivity and immunogenicity. The present invention also provides an S-adenosyl homocysteine ​​artificial complete antigen prepared by the method and an application of the S-adenosyl homocysteine ​​artificial complete antigen in antibody preparation.

This invention relates to an improved process for the industrial manufacture of S-adenosyl-L-methionine (SAMe) of formula (I), which consists of stereo-selective methylation of S-adenosyl-L-homocysteine (SAH) with the enrichment of active (S,S)-isomer.