Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Diabetic nephropathy diagnostic kit and application thereof

A technology for diabetic nephropathy and diagnostic kits, applied in the field of diabetic nephropathy diagnostic kits, can solve the problems of lack of effective markers for diabetic nephropathy, cumbersome process of diagnosing diabetic nephropathy, etc.

Active Publication Date: 2014-11-12
罗国安
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is the lack of effective markers in the diagnosis of early diabetic nephropathy (before stage 3), and the cumbersome diagnostic process of diabetic nephropathy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Diabetic nephropathy diagnostic kit and application thereof
  • Diabetic nephropathy diagnostic kit and application thereof
  • Diabetic nephropathy diagnostic kit and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] In this verification study, a total of 182 subjects with known physical conditions were selected, including 50 healthy subjects, 33 diabetic patients, 33 diabetic nephropathy stage 3 patients, 27 diabetic nephropathy stage 4 subjects, and 39 diabetic nephropathy stage 5 subjects. Mongensen staging method, age 40-75 years.

[0021] 1. Inosine, adenosine combined with S-adenosyl homocysteine ​​(SAH)

[0022] Refer to the table below for the indication range:

[0023] Table 2

[0024] course of disease Inosine mg / L Adenosinemg / L SAH μg / L Diabetic Kidney Disease Stage 4 0.288~0.350 0.509~0.571 16.83~24.28 Diabetic Kidney Disease Stage 5 0.855~1.034 1.712~2.028 108.7~124.8

[0025] Prepare gradient concentration solutions of inosine, adenosine and SAH standard substances respectively. 0.04μg / mL, 0.0625μg / mL, 0.125μg / mL, 0.2μg / mL, 0.4μg / mL; SAH concentration gradient: 2 ng / mL, 8 ng / mL, 40 ng / mL, 160 ng / mL mL, 320 ng / mL.

[0026] Use l...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentration gradientaaaaaaaaaa
concentration gradientaaaaaaaaaa
Login to View More

Abstract

The invention discloses a diabetic nephropathy diagnostic kit and the application thereof, and particularly discloses the application of inosine serving as a biomarker in preparation of a diagnostic kit for diabetes and the diabetic nephropathy, and the application of the combination of the inosine, adenosine and S-adenosyl homocysteine and the combination of the adenosine, the S-adenosyl homocysteine and linoleic acid serving as markers in preparation of the diabetic nephropathy diagnostic kit. The invention also discloses the diagnostic kit prepared by the biomarkers, which can be used for distinguishing the diabetic nephropathy and staging different development stages of the diabetic nephropathy, performing screening and assessment analysis on the treatment medicaments for different development stages of the diseases, and provides accurate basis for the treatment and the diagnosis of the diabetes and the diabetic nephropathy.

Description

technical field [0001] The invention relates to a diagnostic kit for diabetic nephropathy and its application. Background technique [0002] Diabetic nephropathy is one of the most common microvascular complications in diabetic patients and one of the leading causes of death in end-stage renal disease and diabetic patients. Moreover, diabetic nephropathy patients are often complicated by severe macrovascular diseases, such as cardiovascular and cerebrovascular diseases, which further lead to an increase in the mortality rate of diabetic patients. In the diagnosis of early diabetic nephropathy (stage 1 and stage 2), there is a lack of effective diagnostic indicators, and once diagnosed, it has developed to stage 3 or more serious. Therefore, it is of great practical significance to study the early indicators of diabetic nephropathy, as well as the appropriate drug screening and evaluation indicators. [0003] Diabetic nephropathy is a multifactorial and complex disease invo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/88
Inventor 罗国安王义明
Owner 罗国安
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com