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Diabetic nephropathy diagnostic kit and application thereof

A technology for diabetic nephropathy and diagnostic reagents, applied in the field of diagnostic kits for diabetic nephropathy, which can solve the problems of lack of effective markers for diabetic nephropathy and cumbersome diagnostic process of diabetic nephropathy

Active Publication Date: 2013-09-11
罗国安
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is the lack of effective markers in the diagnosis of early diabetic nephropathy (before stage 3), and the cumbersome diagnostic process of diabetic nephropathy

Method used

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  • Diabetic nephropathy diagnostic kit and application thereof
  • Diabetic nephropathy diagnostic kit and application thereof
  • Diabetic nephropathy diagnostic kit and application thereof

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Experimental program
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Effect test

Embodiment 1

[0020] In this verification study, a total of 182 subjects with known physical conditions were selected, including 50 healthy subjects, 33 diabetic patients, 33 diabetic nephropathy stage 3 patients, 27 diabetic nephropathy stage 4 subjects, and 39 diabetic nephropathy stage 5 subjects. Mongensen staging method, age 40-75 years.

[0021] 1. Inosine, adenosine combined with S-adenosyl homocysteine ​​(SAH)

[0022] Refer to the table below for the indication range:

[0023] Table 2

[0024] course of disease Inosinemg / L Adenosinemg / L SAH μg / L Diabetic Kidney Disease Stage 4 0.288~0.350 0.509~0.571 16.83~24.28 Diabetic Kidney Disease Stage 5 0.855~1.034 1.712~2.028 108.7~124.8

[0025] Prepare gradient concentration solutions of inosine, adenosine and SAH standard substances respectively. 0.04μg / mL, 0.0625μg / mL, 0.125μg / mL, 0.2μg / mL, 0.4μg / mL; SAH concentration gradient: 2 ng / mL, 8 ng / mL, 40 ng / mL, 160 ng / mL mL, 320 ng / mL.

[0026] Use li...

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Abstract

The invention discloses a diabetic nephropathy diagnostic kit and the application thereof, and particularly discloses the application of inosine serving as a biomarker in preparation of a diagnostic kit for diabetes and the diabetic nephropathy, and the application of the combination of the inosine, adenosine and S-adenosyl homocysteine and the combination of the adenosine, the S-adenosyl homocysteine and linoleic acid serving as markers in preparation of the diabetic nephropathy diagnostic kit. The invention also discloses the diagnostic kit prepared by the biomarkers, which can be used for distinguishing the diabetic nephropathy and staging different development stages of the diabetic nephropathy, performing screening and assessment analysis on the treatment medicaments for different development stages of the diseases, and provides accurate basis for the treatment and the diagnosis of the diabetes and the diabetic nephropathy.

Description

technical field [0001] The invention relates to a diagnostic kit for diabetic nephropathy and its application. Background technique [0002] Diabetic nephropathy is one of the most common microvascular complications in diabetic patients and one of the leading causes of death in end-stage renal disease and diabetic patients. Moreover, diabetic nephropathy patients are often complicated by severe macrovascular diseases, such as cardiovascular and cerebrovascular diseases, which further lead to an increase in the mortality rate of diabetic patients. In the diagnosis of early diabetic nephropathy (stage 1 and stage 2), there is a lack of effective diagnostic indicators, and once diagnosed, it has developed to stage 3 or more serious. Therefore, it is of great practical significance to study the early indicators of diabetic nephropathy, as well as the appropriate drug screening and evaluation indicators. [0003] Diabetic nephropathy is a multifactorial and complex disease invo...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/88
Inventor 罗国安王义明
Owner 罗国安
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