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Medical usage of S-adenyhomotype cysteine

A cysteine ​​and adenosine isomorphic technology, which is applied in the field of medical application of S-adenosylhomocysteine, can solve the problem that there is no research on the impact of S-adenosylhomocysteine ​​on the immune system

Active Publication Date: 2007-04-04
NINGBO ZIYUAN PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, the effect of S-adenosylhomocysteine ​​on the immune system in vivo has not been studied

Method used

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  • Medical usage of S-adenyhomotype cysteine
  • Medical usage of S-adenyhomotype cysteine
  • Medical usage of S-adenyhomotype cysteine

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0021] Experimental drugs, animals and materials

[0022] Drug name: S-adenosine homocysteine ​​(S-(5'-Adenosyl)-L-homocysteine), MW: 384.4.

[0023] Experimental animals: Balb / c mice, C57BL / 6 mice, 6-8 weeks old, all female mice, purchased from Shanghai Experimental Animal Center of Chinese Academy of Sciences, animal qualification certificate number: Zhongke Hudongguan No. 99- Number 003. MRL-lpr / lpr mice were introduced from Japan and provided by the SPF animal room breeding of Shanghai Institute of Materia Medica, Chinese Academy of Sciences. The animals were kept in a clean animal room of the Shanghai Institute of Medicine, Chinese Academy of Sciences, with a 12-hour light / dark cycle, a room temperature of 24°C, and a humidity of 50-60%.

[0024] Reagents:

[0025] Pertussis toxin (Pertussis toxin, PTX) and Ovalbumin (grade V) were purchased from Sigma (St. Louis, MO, USA).

[0026] Complete Freund's adjuvant (CFA) and Mycobacterium tuberculosis (Mycobacterium tuberculosis H3...

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Abstract

A medical application of S-adenosine homocysteine in preparing immunodepressant with high effect and low poison is disclosed.

Description

Technical field [0001] The invention relates to the process of amino acid metabolism in organisms, S-adenosylmethionine transfers methyl groups to other substances under the action of methyltransferase, and participates in the production of a variety of important biologically active substances containing methyl groups such as proteins and lipids. And nucleic acid. More specifically, S-adenosylmethionine in the body is converted into S-adenosyl homocysteine ​​(S-(5'-Adenosyl)-L-homocysteine, AdoHcy) after it provides a methyl group through the above reaction, and S -Adenosine homocysteine ​​is a powerful inhibitor of S-adenosylmethionine-dependent transmethylation reaction. Background technique [0002] In the biological amino acid metabolism process, S-adenosylmethionine transfers methyl groups to other substances under the action of methyltransferase, and participates in the production of a variety of important biologically active substances containing methyl groups such as prot...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P37/06A61P29/00A61P19/02A61P13/12A61P3/10A61P43/00
Inventor 左建平付云峰
Owner NINGBO ZIYUAN PHARMA INC
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