114 results about "Non human primate" patented technology

Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.

The invention provides isolated non-human primate Fc receptor polypeptides, the nucleic acid molecules encoding the Fc receptor polypeptides, and the processes for production of recombinant forms of the Fc receptor polypeptides, including fusions, variants, and derivatives thereof. The invention also provides methods for evaluating the safety, efficacy and biological properties of Fc region containing molecules using the non-human primate Fc receptor polypeptides.

Methods and compositions of CD45-positive hematopoietic cells and hemangioblasts derived b)y culturing human or non-human primate embryonic stem cells under serum-free conditions in cytokine-rich differentiation medium containing fibroblast growth factor or a related growth factor.

The invention provides a method for preparing mature high-activity dendritic cells. The method comprises the following steps of (1) collecting single karyocytes from peripheral blood or umbilical cordblood; (2) inducing the single karyocytes to be differentiated into dendritic cells; (3) enabling the dendritic cells to be in contact with the non-human primate animal T lymphotropic virus protein from non-pathogenic; (4) screening and identifying the obtained mature high-activity dendritic cells. The invention provides the mature high-activity dendritic cell prepared by the method, and a use method of the cell. The dendritic cell prepared by the method has strong dendritic cell reproductive capability and high activity; the gene modification transmission is convenient; the cell is superiorto the dendritic cell used in the prior art. The cell and the use method have the wide application prospects in aspects of tumor or virus immunotherapy.

Methods and compositions for preventing an immune response to an immunogenic therapeutic agent [i.e. anti-drug antibody (ADA), a.k.a. anti-therapeutic antibody (ATA)] are disclosed. One of the disclosed methods comprises administering an effective amount of an immunosuppressant such as an IL-2 signaling pathway inhibitor, including an antagonist, super agonist or partial agonist to the cytokine IL-2, to the IL-2 receptor (IL-2R), or to IL-2R signal transduction molecules. Inhibitors can be in the form of antibodies or antibody fragments, peptide inhibitors, fusion molecule, small molecules, antibody / small molecule conjugates. Administration of a given inhibitor can decrease the incidence and / or magnitude of an immune response or prevent an immune response, including an antibody response, to a potentially immunogenic therapeutic agent in a non-human primate (NHP). Some of the disclosed methods produce a tolerizing effect in NHPs.

The invention provides an automated training assisting device for training a non-human primate animal to control a mechanical arm to conduct stretching and grabbing. The automated training assisting device comprises a mechanical arm, a three-dimensional storage platform, an animal control device, a microcontroller, a water feeding control system and a PC; the microcontroller is connected with themechanical arm, the three-dimensional storage platform, the animal control device, the water feeding system and the PC separately. The automated training assisting device is reasonable in design, easyto operate and high in training efficiency; the position of a grabbed object can be automatically changed in a three-dimensional space, the grabbing identification range of the mechanical arm, the movement speed, the illuminating range of an LED matrix and other training parameters can be quickly adjusted, stepwise learning training is achieved, the learning difficulty is reduced, the training process is adapted to, and switching can be achieved between the movement mode of the animal control device and the movement mode of the mechanical arm; through the combination of active learning, passive observing and other modes with learning training, reasonable evaluation is made, after training is completed, the evaluation result can be directly used for the next experiment, and it is achievedthat the non-human primate animal automatically controls the mechanical arm to conduct stretching and grabbing training.

The invention discloses a touch-screen multifunctional non-human primate animal cognitive-function testing cage and belongs to the technical field of animal experiment devices. The touch-screen multifunctional non-human primate animal cognitive-function testing cage comprises a testing cage and a transfer cage. An infrared-induction touch screen connected with a computer is fastened on the rear vertical face of the testing cage capable of moving back and forth, an observation window and a movable camera are arranged on the top face, a water supply nozzle is located at the rear locking-fixing position capable of moving vertically in front of the touch face of the touch screen, a feces receiving plate which can be pushed into or pulled out of the lateral vertical face of the testing cage is arranged under a grid-shaped base, and a testing cage door which can be pushed into or pulled out of the side face of the testing cage is arranged on a grid-shaped front vertical face. The transfer cage is provided with truckles and an observation window, and the front vertical face is a push-pull type transfer cage door which can be in butt joint with the testing cage door after being opened. The touch-screen multifunctional non-human primate animal cognitive-function testing cage can be used for flexibly, conveniently, intelligently, efficiently and accurately performing non-human primate animal training and testing based on a modern computer technology, does not need an additionally-equipped corresponding cage, has multiple practical functions and is low in purchase cost and usage cost.

The present invention provides a non-human primate (nhp) pluripotential embryonic stem (ES) cell, which can be used in several ways as described herein, including to generate chimeric primate embryos. The invention further provides methods to determine the differentiation status of an embryonic cell by comparing its transcriptional patterns with those of ES cells at particular stages of differentiation.The invention further provides a non-human primate embryonic germ (EG) cell which can also be used in several ways, including administering the differentiated EG cell line to a patient to treat a number of diseases.Also provided are methods of generating nhp ES cell+primate embryo chimeras, and methods of deriving EG cells.

A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the “pregnancy signature”, also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. Microarrays containing “pregnancy signature” genes or corresponding polypeptides provide another preferred aspect of the invention. Still further, the subject invention can be used to derive animal models, e.g., non-human primate animal models, for the evaluation of the efficacy of putative female fertility treatments.