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Chronic non-alcoholic steatohepatitis non-human primate model, method for building same and application of chronic non-alcoholic steatohepatitis non-human primate model

A primate and steatohepatitis technology, which is applied in the field of non-human primate model construction, can solve the problems of not being able to accurately reflect the pathological process, clinical symptoms and prognosis of NASH, and achieve a simple and easy method. effect, widespread promotion, and low mortality

Active Publication Date: 2018-04-17
江苏珂玛麒生物科技有限公司
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  • Claims
  • Application Information

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Problems solved by technology

None of these models can accurately reflect the real pathological process and clinical symptoms and outcomes of NASH. The models rarely or only partially reproduce a certain part of the pathological characteristics of human nonalcoholic steatohepatitis, and many important diseases such as Neither insulin resistance nor fibrosis reproduced

Method used

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  • Chronic non-alcoholic steatohepatitis non-human primate model, method for building same and application of chronic non-alcoholic steatohepatitis non-human primate model
  • Chronic non-alcoholic steatohepatitis non-human primate model, method for building same and application of chronic non-alcoholic steatohepatitis non-human primate model
  • Chronic non-alcoholic steatohepatitis non-human primate model, method for building same and application of chronic non-alcoholic steatohepatitis non-human primate model

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Embodiment Construction

[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0031] Example Taking an adult cynomolgus monkey as an example, an animal model of non-alcoholic steatohepatitis (NASH) and further accompanied by pathological features of chronic liver fibrosis and early liver cirrhosis was prepared.

[0032] In this experiment, 15 adult cynomolgus monkeys aged 4-6 were selected, weighing 3.8-4.0 kg.

[0033] Experimental group:

[0034] Simple CCl 4 5 rats in the induced liver fibrosis model group were given normal feed and oral CCl 4 (1ml / kg, CCl 4 : olive oil=1:1), three time...

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Abstract

The invention discloses a chronic non-alcoholic steatohepatitis (NASH) non-human primate model, a method for building the same and application of the chronic non-alcoholic steatohepatitis non-human primate model. The chronic non-alcoholic steatohepatitis non-human primate model, the method and the application have the advantages that the chronic non-alcoholic steatohepatitis non-human primate model built by the aid of the method further can be accompanied by pathological characteristics of chronic hepatic fibrosis and hepatic cirrhosis, can be used for research and development of medicines forpreventing or treating chronic non-alcoholic steatohepatitis, the chronic hepatic fibrosis and the hepatic cirrhosis and can be used as an animal model for research on chronic fatty livers, steatohepatitis, the hepatic fibrosis, the hepatic cirrhosis, hepatocellular carcinoma, metabolic diseases, diabetes mellitus and diabetes complications, and accordingly the chronic non-alcoholic steatohepatitis non-human primate model and the method have extremely high application values.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a non-alcoholic chronic steatohepatitis (NASH) and a method for constructing a non-human primate model developed into chronic liver fibrosis and liver cirrhosis and its application. Background technique [0002] Non-alcoholic steatohepatitis (NASH) is a stage with poor prognosis of non-alcoholic fatty liver disease (NAFLD), which can develop into liver cirrhosis or even hepatocellular carcinoma, and the incidence rate is increasing year by year. . Animal models play an important role in exploring the pathogenesis of diseases, evaluating diagnostic methods, and screening drugs for prevention and treatment. In recent years, many scholars have used experimental animals to replicate the pathological model of nonalcoholic steatohepatitis and conducted a lot of research on it. At present, the commonly used animal models of non-alcoholic steatohepatitis at home and abroad include the mode...

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Application Information

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IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 庄永杰陈继巧
Owner 江苏珂玛麒生物科技有限公司
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