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Method for building animal model of social position induced depression

A technology of animal models and social status, applied in the field of life sciences, can solve problems such as unsuccessfully achieving natural modeling, shortening the onset of depression, and not fully simulating the development of human depression

Inactive Publication Date: 2010-07-14
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI +1
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  • Application Information

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Problems solved by technology

However, Shively's chronic stress method has a flaw: it is mixed with the interference of human factors (artificially adjusting the social order of the group), which relatively shortens the onset of depression, and cannot fully simulate the development process of human depression. did not successfully achieve the goal of natural modeling

Method used

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  • Method for building animal model of social position induced depression
  • Method for building animal model of social position induced depression
  • Method for building animal model of social position induced depression

Examples

Experimental program
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Effect test

Embodiment

[0025] Example: The subjects of the experiment were 42 female macaques, aged 6-11, gathered in a natural breeding group.

[0026] In two weeks, the individual's crouching time, voluntary activity time and reaction time to external stimuli were observed and recorded 14 times at intervals, and the total time for observing and recording each individual was equal to 14 hours.

[0027] Calculate the total time of curling up, the total time of autonomous activities and the total time of reaction to external stimuli of each member of the group, and divide the total time of curling up of all individuals into four equal parts in order from high to low, among which the total time of curling up is the least Individuals within the range are defined as normal individuals, a total of 38 normal monkeys; individuals within other ranges are defined as depressed individuals, a total of 4 depressed monkeys, all normal monkeys constitute the normal group, and all depressed monkeys constitute the d...

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Abstract

The invention discloses a method for building an animal model of social position induced depression, which belongs to the technical field of life sciences. The method comprises the following steps of: in natural colonies of non-human primates, recording total curling time, total spontaneous activity time and total external stimuli reaction time of each individual; dividing the total curling time of each individual into four equal parts, wherein the individuals with the shortest curling time are abnormal and others are depressive; performing independent sample t experiments on the hourly average spontaneous activity time and the hourly average external stimuli reaction time of the individuals of the two groups, wherein if the spontaneous activity time and the reaction time of the individuals of the normal group are obviously longer than those of the individuals of the depressive group, the individuals of the depressive group meet behavior characteristic requirements; and measuring hair cortisone content and partial cerebral blood flow values of the individuals of the two groups to perform the independent sample t detection, wherein if the average cortisone content of the individuals of the normal group is obviously lower than that of the depressive group and the average partial cerebral blood flow value of the individuals of the normal group is obviously higher than that of the depressive group, the individuals of the depressive group meet biochemical criterion requirements. The individuals who simultaneously meet the two types of requirements are the built natural depressive models, so the method can completely simulate the evolution of human depression.

Description

technical field [0001] The invention belongs to the technical field of life sciences, and in particular relates to a method for establishing an animal model of depression. Background technique [0002] Depression is a common disease and is likened to a "spiritual cold". A person is likely to suffer from such "spiritual colds" several times in his life. Depression can reduce people's immunity and physiological functions, and may induce angina, asthma, gastric ulcer, cancer and other organic diseases. What's more serious is that 10-15% of depressed patients have different degrees of suicidal tendencies, which brings a heavy burden to society and their families. [0003] In order to understand depression in more detail, a suitable and effective animal model is very important, which can help us: (1) follow up the development of the disease, and conduct research at different times and places after the onset; (2) Collect specimens directly from the ventricle or brain tissue, an...

Claims

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Application Information

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IPC IPC(8): A01K67/02
Inventor 胡新天马原野李燕皎冯晓丽秦冬冬
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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