68 results about "Human ARDS" patented technology

Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

A human T cell clone recognizing an antigen expressed by a synovial cell of a rheumatoid arthritis (RA) patient in HLA-DR-restricted manner is disclosed, which clone is very useful in exploring the pathogenesis of RA and developing a method for treating and preventing RA.

The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.

The present invention relates to the selection of a set of polymorphism makers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to IBD (ex: Chrohn's disease) and/or their response to a particular drug or drugs.

The invention relates to the functional genomic and gene expression detection technology and the analysis technology, and discloses a reagent kit for quantitatively assessing long-term recurrence risks of breast cancer. Particularly, a type of genes capable of being used for breast cancer metastasis and prognostic molecular classification is screened within a human functional genome expression profile range, the detection technology is created, and the reagent kit is prepared and applied to breast cancer metastasis and prognostic assessment for a patient. The reagent kit for quantitatively assessing long-term recurrence risks of breast cancer comprises 21 pairs of primers, 21 specific taqman fluorescent probes, 10XRT-PCR (reverse transcription-polymerase chain reaction) buffer solution, 2.5mM of dNTP (diethyl-nitrophenyl thiophosphate) mixed liquor, reverse transcriptase, DNA (deoxyribose nucleic acid) polymerase, 10XPCR buffer solution and RNA (ribonucleic acid) enzyme inhibitor. The reverse transcription PCR technology is combined with the taqman fluorescent quantitative PCR technology, reverse transcription primers, real-time PCR primers and the taqman fluorescent probes are self-designed and optimized, reverse transcription PCR reagent and taqman fluorescent quantitative PCR reagent are integrated to prepare the detection reagent kit, operation is simple and fast, detection results are more stable, and detection cost is lower.

Many diseases with origin in human gut are of unknown causes, so only symptoms are treated. Endoscopic devices leave about 15′ of gut unexplored other than by autopsy. Thus, a substance and microbe simultaneous sample collecting, testing, evaluation, and characterization system has been invented that will provide data for evaluating functions, macro, and micro processes taking place along entire length of the human digestive and intestinal tract from mouth to anus. The entire digestive process including biochemical reactions and microbe roles, and consequences, as pertain to diseases and illnesses can be ascertained through applications of the system, which includes protocols, for collection and preservation of digestion products for external analysis, measurements of many in vivo conditions, and internally processing data and making decisions based upon said processed data, including administration of medications. The system serves clinical diagnostic, treatment and research purposes, and is a dream tool for gastroenterologists.

The present invention relates to a method for treating impaired respiratory function in a human patient suffering from sleep apnea, such as central sleep apnea or obstructive sleep apnea, comprising administering to said patient an effective amount of gaboxadol per day.

In certain aspects, the present disclosure provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans. In some embodiments, the compositions of the disclosure may be used to treat or prevent sideroblastic anemias and myelodysplastic syndromes or one or more complications associated sideroblastic anemias and myelodysplastic syndromes.

The invention discloses a method for building an animal model of social position induced depression, which belongs to the technical field of life sciences. The method comprises the following steps of: in natural colonies of non-human primates, recording total curling time, total spontaneous activity time and total external stimuli reaction time of each individual; dividing the total curling time of each individual into four equal parts, wherein the individuals with the shortest curling time are abnormal and others are depressive; performing independent sample t experiments on the hourly average spontaneous activity time and the hourly average external stimuli reaction time of the individuals of the two groups, wherein if the spontaneous activity time and the reaction time of the individuals of the normal group are obviously longer than those of the individuals of the depressive group, the individuals of the depressive group meet behavior characteristic requirements; and measuring hair cortisone content and partial cerebral blood flow values of the individuals of the two groups to perform the independent sample t detection, wherein if the average cortisone content of the individuals of the normal group is obviously lower than that of the depressive group and the average partial cerebral blood flow value of the individuals of the normal group is obviously higher than that of the depressive group, the individuals of the depressive group meet biochemical criterion requirements. The individuals who simultaneously meet the two types of requirements are the built natural depressive models, so the method can completely simulate the evolution of human depression.

The invention includes a method of identifying a human subject at-risk of developing SeSAME syndrome. The invention also includes a method of diagnosing a human subject afflicted with SeSAME syndrome. The invention further includes a method of identifying a therapeutic agent that modulates a given KCNJ10 mediated K⁺ current in a mammalian cell. The invention also includes a method of diagnosing a subject as a carrier of SeSAME syndrome.

The present invention relates to a novel use of an α1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in α1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The α1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

The invention discloses an application of a composition packet in preparing food, medicines, health care products and nutrition for improving and treating human Prader-Willi syndrome. The composition packet includes the following compositions each of which is in a uniform dose unit form convenient for dose administration, and each dose unit form is a single-dose physical dispersing unit, wherein the first composition consists of coix seeds, oats, buckwheat, semen lablab album, yellow corn, semen phaseoli, soybeans, rhizoma dioscoreae, fructus ziziphi jujubae, peanuts, lotus seeds and fruits of Chinese wolfberry; the first composition can also consist of rye, wheat, quinoa and hulless barley; the second composition consists of fructus momordicae charantiae, soluble dietary fibers and oligosaccharide; and the third composition consists of soluble dietary fibers and oligosaccharide. By reasonably adjusting the diet nutrition of patients with the human Prader-Willi syndrome, the purposes of relieving, removing, remedying, preventing or improving the symptoms of the human Prader-Willi syndrome and recovering health can be achieved.

Methods and products are provided for determining if a subject having a tumor is (i) at risk of metastasis of the tumor, or (ii) at risk of recurrence of the tumor after treatment of the tumor. Methods of treatment of cancer, tumors and metastasis are also provided.

The invention relates to a detection of four sites of single nucleotide polymorphism (SNP) which are arranged on two human body xenobiotics metabolismenzyme genes including ABCG2 and CYP2E1 and which are associated with the systemic lupus erythematosus (SLE). The invention also can use four sites of single nucleotide polymorphism (SNP) to forecast the liability of systemic lupus erythematosus and to determine the drug to cure the systemic lupus erythematosus. The information provided by the invention is helpful for preventing systemic lupus erythematosus (SLE) and for developing effective new treatments.