85 results about "Nerve motor" patented technology

Apparatus and methods for performing spinal disc lesioning procedures while monitoring the temperature near the spinal nerve roots. A needle containing a thermocouple and an injection bore may be placed between the disc and a nerve root. Temperature near the nerve root may be monitored during the lesioning procedure and if raised to a point where damage to the nerve could occur, the procedure may be stopped before damage is done. Coolant may be injected through the injection bore to lower the temperature near the nerve root. Additional dual purpose needles may be placed on the disc adjacent the opposite nerve root or in the spinal canal at the level of the disc for additional control. A hollow, flexible tip electrode needle may be used to repair and lesion the disc tissue. Prior to lesioning, the electrode may be stimulated to assess motor nerve response and avoid motor nerve damage.

The present invention relates to methods and apparatuses for the detection of neural or muscular activity, analysis of the signals and the subsequent stimulating of neural or muscular tissue based thereon. According to a first aspect of the invention an apparatus for producing a muscular action is provided, comprising a combined sensing and stimulation electrode device comprising at least one neurosense electrode means capable of sensing a nerve signal from a peripheral nerve and at least one stimulation electrode means capable of stimulating a peripheral motor nerve fiber, means for receiving and processing the sensed neurosignals to identify a signal indicative of a specific action, especially a component of the gait performed by the patient and for producing a control signal in response thereto, and means for operating the at least one stimulation electrode means in response to the control signal to produce a stimulation of a peripheral motor nerve fiber.

Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and / or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and / or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

A method for cryogenically treating a target tissue comprises providing a cryogenic device having one or more tissue penetrating needle probes, and advancing the one or more tissue penetrating needle probes through skin disposed above the target tissue into the target tissue. The target tissue comprises a motor nerve. The method also includes cooling the target tissue with the one or more tissue penetrating needle probes, and temporarily disrupting signal conduction from the motor nerve thereby preventing contraction of a muscle operably coupled to the motor nerve. This reduces or eliminates hyperdynamic wrinkles of a patient's face.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

The present invention relates to an appliance for the direct measurement, display, processing and transmission, remotely, of electromyographic signals (EMG) comprising: an electrical stimulator (1) comprising electrodes for the excitation of a peripheral motor nerve; a pair of electrodes (31), for the acquisition of the EMG response at the level of the muscle associated with this peripheral nerve; an acquisition chain (2) driven by a micro-controller (3, 39), presenting means of conditioning of the input signal, comprising at least one differential preamplifier (22, 33), a bandpass filter (25, 34) and an analog / digital converter (ADC) (26, 310), said acquisition chain (2) being linked, via a standardized interface (5), to a computer (4) comprising means of storage (9) and of display of the EMG signals acquired as well as an executable program for effecting the interface with the user (6) and utilizing the data stored; characterized in that the acquisition chain (2) comprises means of automatic adjustment of the amplification gain of the EMG signal (23, 24, 311, 38), via the microcontroller, in such a way that the EMG signal covers the largest possible part of the input voltage span of the ADC (26, 310), hence with conservation of resolution, when the amplitude of the EMG signal decreases.

The present invention relates to an agent for protecting a motor nerve of a patient with amyotrophic lateral sclerosis, which comprises a combination of (a) (2R)-2-propyloctanoic acid or a salt thereof and (b) a therapeutic agent for amyotrophic lateral sclerosis such as riluzole. An agent comprising a combination of (a) (2R)-2-propyloctanoic acid which is orally administered once a day in an amount per dose of about 1200 mg and (b) riluzole which is orally administered twice a day in an amount per dose of about 50 mg is useful for protecting a motor nerve in a patient(s) with amyotrophic lateral sclerosis. The agent can also suppress the respiratory disability associated with the progression of the disease condition and improve the survival rate of the patient(s).

The invention relates to a composite of active ingredients of Chinese herb medicine used for preventing the damage of cerebral ischemia and relevant diseases, in particular to a preparation which is prepared by the active ingredients of the Chinese herb medicine; the preparation is prepared by the active ingredients of the Chinese herb medicine and the conventional preparation technique which is used by carriers permitted by pharmacy, and comprises the following components with the parts by weight: 2 to 10 parts of ginsenoside Rb, 2 to 10 parts of ginsenoside Rg1, 1 to 5 parts of ginsenoside Rd, 1 to 5 parts of ginsenoside Re, 2 to 10 parts of stilbene glycoside, 1 to 5 parts of ginkgolide and 1 to 5 parts of flavonoid mixture which consists of kaempferol and quercetin with the weight rate to be 1:1. The invention has the advantages that the defects that in the traditional compounded Chinese medicine, the composition is complex, the product quality is not controlled effectively and the curative effect is not stable are overcome, has clear ingredients, definite effect, stable quality and obvious control effect on ischemic stroke, sequela, cerebral arteriosclerosis and vascular dementia, can improve the functions of motor nerve, and learning and memory of the patients, has low toxicity and simple preparation method without obvious side effect and is suitable for industrial mass production.

The invention discloses a quaternary ammonium salt compound and a preparation method and application thereof. The invention provides a compound shown in a formula I with a novel structure, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof. The compound has the advantages of rapid onset of action, long-termlocal anesthesia effect after single administration, sensory nerve block time greater than motor nerve block time, and both long-term local anesthesia effect and selective local anesthesia effect, remarkably reduces side effects of QX314 and QX314 compositions and quaternary ammonium salt compounds with surfactant structural characteristics, and has better safety. Namely, the compound of formula Iand the pharmaceutically acceptable salt thereof can be used for preparing safe drugs with long-term local anesthesia and selective local anesthesia effects, and have the advantages of long-term local anesthesia, good local anesthesia selectivity, less nerve damage and high safety.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

The invention relates to a preparation method of ropivacaine mesylate injection packed by a soda-lime glass bottle, which comprises the following processing steps of ingredient preparation, liquor preparation, soda-lime glass bottle and rubber plug cleaning, filling, capping, sterilization, lamp test, labeling, packing and finished product inspection. The injection is subject to a filtration sterilization processing step once and a flowing steam sterilization processing step once, wherein microorganisms larger than 0.22 microns in liquid medicine are removed by a filter method, microorganismssmaller than 0.22 microns are killed by flowing steam sterilization, and insoluble particles in the liquid medicine are removed during filtration sterilization simultaneously, thereby greatly reducingthe occurrence of phlebitis; and the invention is packed by the soda-lime glass bottle which has the advantages of heat resistance, acid and alkali resistance, large strength, and the like, thereby ensuring the stability of the medicine. Clinic comparison tests show that the ropivacaine mesylate injection packed by a soda-lime glass bottle has the advantages of quicker effect, long action time, reliable anesthetic effect, small toxicity to heart, separate blocking pf sensory and motor nerves, and the like, thereby being suitable for anesthesia in surgeries and postoperative analgesia.

Neural bridge devices for providing ionic communication across damaged or separated portions of a neuron, or between a neuron and an electronic device, are disclosed. The neural bridge devices can include an ionically conductive polymer that may functionally replace the biological conduction of action potentials along an axon, to restore sensory or motor nerve function, and may enhance neuronal healing.

The guide objects 40L and 40R instruct the movements of the respective left and right hands. The image sensor 54 captures images of the input instruments 3L and 3R which are worn on left and right hands respectively and the cursors 70L and 70R are connected with the movements of the input instruments 3L and 3R by processing the result of the imaging. A series of the processing and transmission of information in the order of the eyes, the visual nerve, the brain, the motor nerve, and the hands and arms are performed inside of a human body, which are not performed in a normal life, by making the operator perform the independent motions of the respective left and right hands, which are not performed in a normal life.

Apparatus for producing a dorsiflexion of the foot of a patient comprises a combined sensing and stimulation electrode device having neurosense and stimulation electrode means capable of sensing a nerve signal from a peripheral nerve and stimulating peripheral motor nerve fibres. The neurosense and stimulation electrode means are implantable above the knee of a patient. Means for receiving and processing the sensed nerve signals are provided to identify a signal indicative of the timing of hell strike and heel lift of the patient and for producing a control signal in response thereto. Means for operating said neurosense and stimulation electrode means in response to the control signal to produce stimulation of the peripheral motor nerve fibres are also provided.

The invention discloses anMI-BCI system based on multi-scene induction and a control method thereof. The system four types of target guide type motor imagery induction scenes, namely sound characters, picture videos, 3D life scenes and virtual game scenes. a subject is inducted to perform motion imagination at different angles. During training, multi-channel EEG signals in a brain motion area are collected. Through signal preprocessing, feature extraction and PSO-SVM intention recognition, a result is outputted to a virtual scene for interactive control, thereby forming a closed-loop feedback training system. A dynamic brain topographic map is drawn by evaluating the nerve activation degree of a motion area so that visual nerve feedback reflecting the brain activation condition is provided for the subject. Adaptive switching adjustment is made on the training scene according to the current nerve activity degree to ensure that the subject is continuously in a motor nerve maximum degree activated state so as to improve the recognition rate of the system.

A surgical method for gastrocnemius muscle reduction is provided. The method may search for a motor nerve associated with a gastrocnemius muscle of a patient, inserts a probe by penetrating an epidermis around the motor nerve and locates a tip of the probe in the motor nerve, stimulates the motor nerve through supply of an electric signal to the probe, thereby shutting down the motor nerve.

A vaccine for reducing disease progression, and / or protection of motor nerve degeneration, and / or protection from glutamate toxicity in motor neurone disease (MND), particularly amyotrophic lateral sclerosis (ALS), patients, comprising an active agent selected from the group consisting of Cop 1, a Cop 1-related peptide, a Cop 1-related polypeptide, and poly-Glu, Tyr. The active agent is preferably Cop 1 or poly-Glu, Tyr, and can be administered with or without an adjuvant.

The invention discloses a hand automatic rehabilitation training system and training method of a hemiplegic patient. The hand automatic rehabilitation training system comprises a double-core embeddedmicroprocessor module, a front arm muscle body module, a surface electromyogram signal acquiring module, an electromyogram decoding module, a wireless communication module, a power source management module, a detection module, a rehabilitation glove module, a driving module which is used for driving a motor on each finger to work, a neural prosthesis module and an upper computer module. A driving-driven control strategy is adopted by the training method, and a wearable glove system and a human body control system can be linked to reshape motor nerves; a monotonous stimulation mode is changed,muscle fatigue is avoided, and the nervous function is rebuilt; by conducting blind source separation on a surface electromyogram signal, the decoding precision is improved, so that rehabilitation training pays more attention to improving the ADL capacity. The hand automatic rehabilitation training system and training method of the hemiplegic patient have the obvious advantages of being intelligent, high in practicability, convenient to use and the like; the patient can automatically conduct hand rehabilitation training at home, and the application value is high.

A system for alleviating spasticity of a skeletal muscle having an associated motor nerve. The system may include a needle probe having at least one needle. The at least one needle has a proximal end, a distal end, and a needle lumen therebetween. The needle is configured for insertion proximate to the nerve. A cooling fluid supply lumen can extend distally within the needle lumen to a distal portion of the needle lumen. A cooling fluid source is couplable to the cooling fluid supply lumen to direct cooling fluid flow into the needle lumen. A controller having at least one processor configured to implement a spasticity treatment algorithm for controlling the cooling fluid source so that liquid from the cooling flow vaporizes within the needle lumen to provide a treatment phase to the motor nerve such spasticity of the skeletal muscle is mitigated.

The invention relates to the technical field of the computer and discloses a method and a system for monitoring a motion action condition. The method comprises the steps of: outputting a reference signal at a preset frequency; acquiring a trigger signal trigged by the action of the user according to the frequency of the reference signal in real time; respectively comparing the frequency of each trigger signal with that of the reference signal; and determining the action response condition of the user according to the frequency compared result of the trigger signal and the reference signal. The system comprises a reference signal output unit, a trigger unit acquiring unit, a frequency discriminating unit, an analyzing unit and the like. According to the method and the system, the frequency of the trigger signal corresponding to each action is compared with the frequency of the reference signal, the action response condition of the user, which is judged according to the frequency compared result, conforms to the reality better, and conforms to a principle of the motor nerve coordination theory better.

A method of monitoring relative nerve health and the presence of neuropraxia is described. The methods utilize the integration of a waveform function of an elicited or monitored nerve response to provide an indication of the strength of a detected signal from a nerve and thus the relative health and integrity of the nerve. In some embodiments motor nerve stimulation innervates muscle and an EMG waveform is obtained in response thereto. The integration under the waveform is expressed and an indexed value indicating a percentage of a certain threshold value. Methods set forth provide a more reliable status of a nerve in real-time and allow action to be taken to reduce neuropraxia or prevent permanent nerve damage.

This invention relates a kind of contact intelligent alternate device based on move body's action which concludes: item loop, angular transducer, signal transfer module, digit signal processor. The detection method of the invention bases on the move body wearing item loop and makes the angular transducer installed in the item loop shape changed by the move body's movement and then judges the movement location of the move body; the deformation variable of angular transducer is transferred to the analog variable through the signal transfer module and then outputs to the digit signal processor and the digit signal processor transfers the analog variable to the digit variable by using the inner AD transfer module of it and then analyses the multiple angular transducer according to the fusion algorithm then judges the location of the present move body. It resolves the problem that the measurement for the move body is not precise enough by using the non-contact transducer. This invention offers a kind of simple, convenience, high measurement precision interactive device for the high vertebra injury and motor nerve disease patient and other demand occasions.

The invention relates to a hand function rehabilitation training system based on Leap Motion and VR and an implementation method of the system. According to the hand function rehabilitation training system based on the Leap Motion and VR and the implementation method of the system, a sensing capture technology and a virtual reality technology are combined; Leap Motion hand movement tracking and high-precision finger recognition technology are adopted to acquire the motion data of the hand of a user, the motion data are mapped to an immersive virtual scene constructed by the VR so as to be applied to real-time interaction; and training tasks which are closed to daily life such as gesture training and finger control ability improvement training such as pinch by two fingers, grasp by a hand in a spherical shape, and grasp by a hand in a columnar shape can be set; and rehabilitation programs can be provided for users with hand dyskinesia caused by illness or injury. With the system of theinvention adopted, the interest and initiative of the user's in rehabilitation can be improved, the effect of the motor nerve function reconstruction of the user can be accelerated; and the current shortage of physician resources can be effectively alleviated.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.