63 results about "Euphorbia acanthothamnos" patented technology

The invention discloses a plant-derived pesticide and its preparation method and use and belongs to the technical field of pesticide preparation. The plant-derived pesticide is prepared from tobacco, common threewingnut root, capsicum, rhizome of Chinese monkshood, pyrethrum, Azadirachta indica, tea leaves, patrinia herb, bitter herbs, wormwood, ash bark, radix sophorae flavescentis, Euphorbia songarica Boiss, Derris fordii Oliv., Chinese prickly ash, purslane, mandala, Anabasis Aphylla L., leaves of Salix babylonica, leaves of Pterocarya stenoptera and water. The plant-derived pesticide is prepared by soup extraction, condensation, drying, crushing, sieving and disinfection. The plant-derived pesticide is nontoxic and harmless, does not produce residues, is harmless, is environmentally friendly, does not pollute the environment, can effectively prevent and control injurious insects such as yellow spider, arrowhead scales, leaf roller moth and fruit fly, has a one-step killing rate of 95.41% or more, has no drug resistance and can be used for 4-6 years.

The invention relates to a traditional Chinese medicine insecticide and a preparation method thereof; the traditional Chinese medicine insecticide comprises the herbal medicine of Chinese azalea fruit, flos daturae, arisaema, anisodus acutangulus, sclerotium mylittae, radix aconiti agrestis, bluestone, aconite, cinnabar, croton and euphorbia. The herbal medicine is prepared into the traditional Chinese medicine insecticide after being processed, decocted and filtered, various agricultural pests can be effectively killed, the killing rate is above 90 percent, and the pure traditional Chinese medicine insecticide is green and environmental-friendly, does not pollute the environment and crops, is convenient to prepare, is low in cost, and is easy to popularize and use.

The invention discloses a botanical insecticide for fruit trees and a preparation method and an application thereof, and belongs to the technical field of insecticide preparation. The botanical insecticide for fruit trees comprises the following raw materials: scutellaria baicalensis, purslane, datura stramonium, pyrethrum, paulownia leaf, sophora alopecuroide, magnolia cortex, melia azedarach, wasabi, chinaberry bark, ash bark, sophora flavescens, euphorbia soongarica, anabasis aphylla, dioscorea zingiberensis, lettuce, mint, tripterygium wilfordii, salix babylonica leaf, Chinese prickly ash and water. The botanical insecticide for fruit trees is prepared by steps of medical liquid extraction, concentration, drying, crushing, sieving, sterilization and the like. The botanical insecticide for fruit trees has advantages of nontoxic component and no residue, is pollution-free, green and environmentally friendly, and will not cause environmental pollution. The botanical insecticide for fruit trees can effectively control plant insects such as citrus bud mite, Aonidiella aurantii, papilionoidea, tortrix and the like. One-time killing rate reaches 95.56% and above. The plant insects have no drug resistance and can be used for 4-6 years.

The invention discloses a tissue culture and rapid propagation method for euphorbia lathyris. The euphorbia lathyris is a biennial herbaceous plant of euphorbia of euphorbiaceae, and the seeds are also named semen euphorbiae lathyridis. The euphorbia lathyris is a traditional Chinese medicine of China, has the functions of relieving water retention and eliminating swelling, relieving blood and removing stasis, is a special-effect medicine for treating advanced schistosomiasis, and has an anti-tumor effect. The euphorbia lathyris is also an ideal energy plant. The oil content of the seed reaches up to about 45%, and the euphorbia lathyris is one of the excellent raw materials for preparing biodiesel. By taking a euphorbiae lathyridis seed as an explant, an euphorbiae lathyridis in vitro re-plant is successfully obtained through processes including callus induction, proliferation, differentiation, rooting, acclimatization and transplanting and the like and a fast propagation technical system for tissue culture of euphorbia lathyris is established, so that the use level of the seeds in cultivation production is saved, the output of medicinal materials is improved, and a foundation is laid for further conducting a study on genetic transformation of the euphorbia lathyris.

The invention relates to a botanical pesticide, particularly to a plant extract composition for preventing and treating apple tree canker and a preparation method thereof. The plant extract composition solves the problems of single material, ideal effect and the like of the existing pesticide for preventing and treating apple tree canker. The plant extract composition is composed of 0.5 to 1.5 parts of kuh-seng fruits, 1 to 3 parts of radix sophorae flavescentis fruits, 0.5 to 1.5 parts of melia toosendan fruits, 0.3 to 0.7 parts of euphorbia fischeriana roots, and 0.2 to 0.4 parts of tobaccos. With repeated testings, the technical scheme provides a novel botanical pesticide with high effect, low toxicity, low residue and environment friendliness. The botanical pesticide has profound significances for protecting environment, avoiding the apple tree canker as a devastating disease in growth of the apple tree and reducing arsenic content in the soil.

The invention relates to a terpenoid in euphorbia soongarica as well as a preparation method and application of the terpenoid. The method takes herb of euphorbia soongarica (E.soongarica) as a raw material, and comprises the following steps: extracting with an organic solvent, separating by utilizing three to four methods in a solvent extraction method, a normal phase silica gel column chromatography, a reverse phase silica gel column chromatography and a Sephadex LH-20 gel column chromatography, so as to obtain 10 new terpenoids (comprising 5 diterpenes, 3 nortriterpenoid and 2 triterpenoid compounds). The obtained 10 new terpenoids are subjected to multi-drug drug resistance reversal activity determination and a result shows that the new terpenoid has different extents of multi-drug drug resistance reversal activity and can be used for preparing a multi-drug drug resistance reversal medicine or can be combined with an anti-tumor medicine to prepare an anti-tumor combined medicine.

The medicine for treating hepatosis and nephrosis is prepared with 14 kinds of Chinese medicinal materials, including licorice, kansui root, pharbitits seed, tangerine peel, cassia, euphorbia, etc in certain weight proportion and vinegar. Its preparation process includes the steps of frying euphorbia in vinegar, frying kansui root and half of the licorice and pharbitits seed, mixing all the materials, crushing, and further treatment to prepare medicine powder or water bolus. The medicine has the features of small dosage, quick acting, high curative effect, taking convenience and relatively low cost.

The invention belongs to the field of natural pharmaceutical chemistry and relates to a method for preparing jolkinolide B. The method comprises the following steps: taking euphorbia jolkini roots, crushing, screening by a sieve with 40-60 meshes, feeding the euphorbia jolkini roots to an extraction kettle, carrying out supercritical co2 extraction by using ethanol water solution with the volume percentage of 75% as an entrainer, collecting extract liquid, degreasing with heptane after recovering ethanol, carrying out high-speed counter-current chromatography by using heptane-ethyl acetate-acetonitrile-water as a solvent system and drying the fraction to obtain the jolkinolide B. Jolkinolide B products prepared by the method have the advantages of having no pollution and high yield, and the method is suitable for industrial preparation of jolkinolide B.

The invention discloses a novel pesticide, and a preparation method and an application thereof, and belongs to the technical field of preparation of pesticides. The novel pesticide comprises, by weight, leaves of Salix babylonica.L, Piper methysticum Forst, Camellia Sinensis leaf, Anabasis aphylla L., paulownia leaf, Derris fordii Oliv., garlic, neem, horseradish, Pterocarya stenoptera leaves, Cortex Fraxini, Sophora flavescens, Euphorbia soongarica, pyrethrum, onion, patrinia herb, purslane, Radix Scutellariae, aloe, Cortex Magnoliae Officinalis and water, and the novel pesticide is prepared through the steps of medicine solution extraction, concentration, drying, crushing, sieving and disinfection. The novel pesticide has the advantages of nontoxic component, no residue, no nuisance, simple production method, low cost and good application effect, can effectively prevent and treat yellow spiders, Parlatoria pergandii Comstock, papilios, leaf miner and other plant pests, has a primary killing rate reaching 96.06% or above, has no medicine resistance, and can be used for 4-6 years.

The present invention provides a method for the synergistic control of undesirable plants such as Ipomoea, Cyperus, Sida and Euphorbia which comprises applying to the plants or their locus a synergistically effective amount of a combination of glyphosate and an imidazolinone compound. Further provided are synergistic herbicidal compositions comprising glyphosate and an imidazolinone compound, and specifically concentrated aqueous herbicidal compositions of imidazolinyl acid salts and glyphosate salts.

The invention discloses an externally-used analgesic medicament, which is prepared from Kusnezoff monkshood root, shortstalk monkshood root, star aniseed, Eucalyptus globules leaf, notoginseng, Eriosema himalaicum Ohashi and drynaria by a predetermined weight proportions.

The invention discloses a botanical pesticide and a preparation method thereof. The botanical pesticide comprises solvent extraction liquor consisting of, by weight, 60-300 parts of tobacco, 40-300 parts of camphor, 10-100 parts of Artemisia desertorum, 20-120 parts of Inula britannica, 10-100 parts of Tagetes erecta L., 10-100 parts of Anisodus tanguticus, 20-80 parts of Euphorbia Esula Linn., 50-200 parts of Artemisia annua Linn. and 40-200 parts of Plantago depressa Willd., and solvents include water, ethanol, glycerol and petroleum ether. The botanical pesticide is remarkably effective in killing multiple kinds of pests, long in pesticide effect lasting time and free of environmental pollution and provides functional substances for crop growth.

The invention relates to macrocyclic diterpene compounds in fruit of euphorbia sororia A. schrenk as well as a preparation method of the macrocyclic diterpene compounds and use of the macrocyclic diterpene compounds in reversion of multidrug resistance. Three new macrocyclic diterpene compounds are separated from the fruit of the euphorbia sororia A. schrenk, and are then subjected to determination of activity of the reversion of multidrug resistance; a result proves that the macrocyclic diterpene compounds (I)-(III) have different levels of the activity of the reversion of multidrug resistance, can reverse the drug resistance of drug-resistant cells to anticancer drugs to varying degrees when being combined with the anticancer drugs for use, and can be used for preparing drugs with the reversion of multidrug resistance.

The invention relates to a preparation method and application of euphorbia sororia fruit grease and a derivative thereof. Grease in euphorbia sororia fruits is extracted through CO2 supercritical fluid extraction; the grease is separated through molecular distillation to obtain essential oil; and the essential oil is subjected to methyl esterification or ethyl esterification to obtain the derivative. The method is carried out at lower temperature, the used solvent CO2 is nontoxic and residual free, an air source is stable and can be recycled, the extraction process is simple, the extraction efficiency is high, and the yield is over 1.2 times higher than that of a solvent method. The euphorbia sororia fruit grease and the derivative thereof obtained by the method are applied to the preparation of medicines for improving memory of patients with dementia.

The invention discloses an ellagic acid compound, the preparation thereof and applications in anticancer drugs. The ellagic acid compound is an anticancer monomer compound obtained by extracting and separating from hylonoma euphorbia root (the root and the aerial part of the euphorbia hylonoma which belongs to euphorbia). The preparation method thereof is as follows: firstly, ethanol is used for extracting the crushed air dried hylonoma euphorbia root, and obtaining extractum by concentration; secondly, chloroform and ethyl acetate are used for extracting, passing a chromatography respectively, and an eluent is used for eluting to obtain two ellagic acid compounds. The two ellagic acid compounds can inhibit the growth of human hepatoma cells and gastric cancer cells obviously by anticancer pharmacological experiments, and have the advantages of the wide anticancer spectrum, the strong antitumor activity, etc., thus being capable of being used for preparing anti-hepatoma or anti-gastric cancer drugs after combined with the carriers and excipients accepted in pharmacy.

The invention belongs to the medical technical field, and specifically relates to a preparation method for ebracteolatain A and an application of the ebracteolatain A in preparation of a breast cancer medicine. An extracting process comprises the steps of extracting euphorbia fischeriana steud medical material powder by petroleum ether, ethyl acetate and n-butyl alcohol, and next, performing separation the abovementioned parts by a silica gel column chromatography. The preparation method is simple, quick and convenient, the reproducibility is high, and the extracting purity is high; in the obtained compound, a diphenylmethane compound has relatively high breast cancer cell viability resistance while 2, 4-dihydroxyl-6-methoxyl-3-methyl-1-acetyl benzene has no obvious breast cancer cell viability resistance; and therefore, the compound with the diphenylmethane mother nucleus can obviously suppress the breast cancer cell viability, and the compound has certain structure-function relationship.

The invention discloses application of euphorbiaceous acid to biopesticides and particularly relates to application of the euphorbiaceous acid to resistance to rice blast of plants, plant anthracnose, speckled leaf blotch of plants and wheat snow mould leaf blight of plants. The euphorbiaceous acid provided by the invention is capable of effectively inhibiting various plant pathogens, and the selection range of biological-source antibacterial agents is broadened.

The invention belongs to the field of organic chemistry, and particularly relates to moleplant seed diterpenoid derivatives with high MDR reversal activity and application thereof. The novel moleplant seed diterpene derivatives are extracted from euphorbia plant moleplant seeds, the compounds are subjected to structural modification, a series of compounds are designed and synthesized, and the reversal activity in MCF-7 / ADR cells is superior to that of verapamil, wherein the reversal multiple of the compound 29 is as high as 911.94.

The invention discloses a Chinese medicinal preparation for controlling parasites of aquatic animal as well as a preparation method and application thereof. The Chinese medicinal preparation for controlling the external parasites of the aquatic animals is prepared by the following steps: (1) carrying out Soxhlet extraction on euphorbia fischeriana by using 80% ethanol and collecting an extracting solution; (2) extracting by using petroleum ether; (3) extracting by using ethyl acetate to obtain solid residues; (4) eluting the solid residues by using ethanol, and volatilizing a solvent to obtain an euphorbia fischeriana ethyl acetate extract; and (5) weighing 3-10g of the extract obtained in (4), dissolving the extract completely by using acetone, adding 5-10g of emulsifier and 1-2g of stabilizer, and fixing the volume to be 100ml by using acetone. The method can be used for separating active parasite-killing components of the euphorbia fischeriana, is feasible and is convenient to operate, the safety concentration of the euphorbia fischeriana extract to crucian and grass crap is 2.61ppm and 2.38ppm respectively, thus the Chinese medicinal preparation is relatively safe for fish, can be applied to control of the external parasites of the aquatic animals in aquaculture production and is suitable for meeting the requirements of intensified and large-scale aquaculture.

The invention relates to an extraction and separation method of macrocyclic diterpenoid components in Euphorbia sororia A.Schrenk fruits and an application thereof, ripe fruits of Euphorbia sororia A.Schrenk are used as raw materials, solvent extraction, solvent extraction and silica gel column chromatography are adopted for separation to obtain macrocyclic diterpenoid components 1-8, and through high performance liquid chromatography, the content of the macrocyclic diterpenoid compound in the component is more than 60%. The activity tests on the components 1-8 show strong multidrug resistance reversal activity, can reverse drug resistance of drug-resistant cells to antitumor drugs to a certain extent when being combined with the antitumor drugs, and can be used as multidrug resistance reversal drugs.

The invention belongs to the technical field of medicine and relates to a preparation method of a diphenylmethane compound, in particular to two diphenylmethane compounds, ebracteolatain A and 3,3'-diacetyl-2,4'-dimethoxy-2',4,6,6'-tetrahydroxy-diphenyl methane extracted from euphorbia fischeriana. An extracting process is that petroleum ether, ethyl acetate and n-butyl alcohol are adopted to extract euphorbia fischeriana medicinal material powder, and then the parts are separated through a silica-gel column chromatography method. The preparation method is simple, quick, convenient, good in reproducibility and high in extracting purity. In the obtained compound, the diphenylmethane compound has the good effect of resisting breast cancer cell activity, and 2,4-dihydroxyl-6-methoxy-3-methyl-1-acetophenone has no obvious effect of resisting breast cancer cell activity. Thus it can be seen that the compound provided with a diphenylmethane mother nucleus can remarkably inhibit the breast cancer cell activity, and the type of compound has certain structure-function relationship.

Oral pharmaceutical compositions comprising dry extract of Euphorbia prostrata from about 0.1% to about 99% by weight wherein the effective average particle size of the dry extract of Euphorbia prostrata is not more than about 500 microns with pharmaceutically acceptable excipient(s) and process(s) for the preparation of such compositions useful for the treatment of anorectal disease and colonic diseases such as hemorrhoids, fissures, cracks, fistulas, abscesses, inflammatory bowel disease and the like are provided. Further, the pharmaceutical compositions of the present invention provides for the administration of a therapeutically and / or prophylactically effective amount of the Euphorbia prostrata wherein the compositions possess properties to control inflammation, prevent capillary bleeding and fragility in mammalians, particularly human beings. Furthermore, the compositions preferably provides a release of not less than about 50% of the dry extract of Euphorbia prostrata in first 15 minutes and not less than about 80% of dry extract of Euphorbia prostrata after total dissolution study of about 60 minutes when tested in accordance with the dissolution method described herein employing physiological pH range of about 2 to about 7.5 optionally with surfactant(s). Preferably the compositions of the present invention are in the form of tablets, minitablets, powders, capsules, pellets, granules, beads, compacts and the like. The present invention also provides and prophylactic and / or therapeutic methods of using such compositions for the treatment of anorectal diseases including hemorrhoids and colonic diseases.

The invention relates to the technical field of medicines for extracting and separating effective components in medicinal plants, in particular to a preparation method of ingenane diterpenoid compounds. The preparation method comprises the following steps of by taking dry tuberous roots of euphorbia kansui (Euphorbia kansui T.N.Liou ex T.P.Wang) as a raw material, extracting with an organic solvent, extracting, carrying out alkaline hydrolysis, carrying out macroporous resin column chromatography, and carrying out high performance liquid chromatography separation, thereby obtaining the product. According to the method, the separation efficiency and the yield can be greatly improved, the yield of the 20-deoxyingenol is over 100mg / kg, the yield is high, the repeatability is good, and the requirements of industrial production can be met after process amplification.

The invention provides an euphane triterpene tripterygium wilfordeuphone (a compound shown as a formula I defined in the description), a method for extracting the compound from a tripterygium wilfordii plant body, a pharmaceutical composition which takes the compound shown as the formula I as an active ingredient and is used for treating and preventing tumors, and application of the compound and the pharmaceutical composition thereof in preparation of medicines for treating and preventing tumors.

Oral pharmaceutical compositions comprising dry extract of Euphorbia prostrata from about 0.1% to about 99% by weight wherein the effective average particle size of the dry extract of Euphorbia prostrata is not more than about 500 microns with pharmaceutically acceptable excipient(s) and process(s) for the preparation of such compositions useful for the treatment of anorectal disease and colonic diseases such as hemorrhoids, fissures, cracks, fistulas, abscesses, inflammatory bowel disease and the like are provided. Further, the pharmaceutical compositions of the present invention provides for the administration of a therapeutically and / or prophylactically effective amount of the Euphorbia prostrata wherein the compositions possess properties to control inflammation, prevent capillary bleeding and fragility in mammalians, particularly human beings. Preferably the compositions of the present invention are in the form of tablets, minitablets, powders, capsules, pellets, granules, beads, compacts and the like. The present invention also provides prophylactic and / or therapeutic methods of using such compositions for the treatment of anorectal diseases including hemorrhoids and colonic diseases.

The invention belongs to the field of organic chemistry, and particularly relates to Semen euphorbiae diterpene derivatives with MDR reversal activity and application of the Semen euphorbiae diterpene derivatives. According to the invention, the novel Semen euphorbiae diterpene derivatives are extracted from euphorbia plant Semen euphorbiae, and are subjected to structural modification, a series of compounds are designed and synthesized, and the reversal activity in MCF-7 / ADR cells is superior to that of verapamil, wherein the reversal multiple of the compound 17 is up to 460.32.

The invention belongs to the medical technical field, and specifically relates to a preparation method for ebracteolatain A and an application of the ebracteolatain A in preparation of a breast cancer medicine. An extracting process comprises the steps of extracting euphorbia fischeriana steud medical material powder by petroleum ether, ethyl acetate and n-butyl alcohol, and next, performing separation the abovementioned parts by a silica gel column chromatography. The preparation method is simple, quick and convenient, the reproducibility is high, and the extracting purity is high; in the obtained compound, a diphenylmethane compound has relatively high breast cancer cell viability resistance while 2, 4-dihydroxyl-6-methoxyl-3-methyl-1-acetyl benzene has no obvious breast cancer cell viability resistance; and therefore, the compound with the diphenylmethane mother nucleus can obviously suppress the breast cancer cell viability, and the compound has certain structure-function relationship.

A pharmaceutical composition for use in the treatment of cancer is provided. The composition includes cannabidiol (CBD) and one or more of the following compounds: D-limonene, astaxanthin, malunggay, euphorbia hirta, pao extract, copaiba and ampalaya.

The invention discloses a navel externally-applied plaster for adjuvant therapy of cancer and a preparation method thereof. The navel externally-applied plaster is prepared from the following components of musk, natural calculus bovis, radix euphorbiae lantu, airpotato yam rhizome, tripterygium hypoglaucum, medical stone, bee pollen, pine pollen, semen momordicae, cortex cinnamomi, realgar, arsenic, processed semen strychni, bulb of edible tulip, dried lacquer, raw rhizoma pinelliae, garden balsam seeds, venenum bufonis, euphorbia kansui, euphorbia pekinensis roots, roots and leaves of wikstroemia indica, moleplant seed, rhizoma anemarrhenae, muskmelon pedicel, chalcanthite, gamboge, borneol, pseudobulbus cremastrae seu pleiones, semen pharbitidis, seaweed, kelp, roasted pangolin, white muscardine silkworm, sea clam powder, dragon bone and conch shell. The application amount is determined, and during preparation, the medicines of all the components are ground into fine powder, are prepared into plaster through an excipient, and are put into a patch. The externally-applied navel patch is used for treating cancers in an auxiliary manner, and a good treatment effect is also achieved clinically.