The invention discloses 3-methoxymethyl-2,3-dihydro-[1,4]dioxano[2,3-f]
quinazoline-10-amine compound and a preparation method thereof, and application of the compound as an
epidermal growth factor receptor inhibitor for treating cancers, belonging to the field of
biology. The compound is an N-substituted phenyl-5-substituted alkoxy-3-methoxymethyl-2,3-dihydro-[1,4]dioxano[2,3-f]
quinazoline-10-amine compound as shown in a formula (I) which is described in the specification, or a pharmaceutically acceptable salt or a
prodrug molecule thereof. In the formula (I), R<1> is selected from a group consisting of -H, C1-5 straight-chain or branched-chain
alkyl groups, alkyloxy groups, alkyloxy-substituted C1-5 straight-chain or branched-chain
alkyl groups, etc.; R<2> is selected from a group consisting of -H,
halogen, aromatic alkyloxy groups, C1-3
alkyl groups, and C1-3 straight-chain or branched-chain alkoxy groups; and R<3> is selected from a group consisting of -H,
halogen, C1-4 unsaturated alkyl groups, nitro groups, cyano groups and C1-3 straight-chain or branched-chain alkoxy groups. The compound provided by the invention can be applied to treatment or prevention a variety of cancers.