39 results about "Bioenhancer" patented technology

The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of anti-infective. This may be usefuil to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease and to lower the concentration of antiinfectives necessary to inhibit the growth of microbial strains.

The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (-) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

A water based, alcohol-free, skin sanitizing solution with a natural skin softener, where the nature of the biocidal enhancer used in the process of making the solution significantly increases efficacy while simultaneously enabling much more economical manufacturing, processing and transportation of the product. Because it is water based, no further moisturizing additives are required, and those with sensitive skin, diabetes, allergies or religious beliefs are able to use the product without concern.

A water-based, alcohol-free, skin sanitizing and wound healing solution with a natural skin softener, where the nature of the biocidal enhancer used in the process of making the solution significantly increases efficacy while simultaneously enabling much more economical manufacturing, processing and transportation of the product. As the present solution is water-based, no further moisturizing additives are required, and those with sensitive skin, diabetes, allergies or religious beliefs are able to use the product without concern.

The invention relates to a biological enhancer for ruminant feeds, and a preparation method for the biological enhancer. The biological enhancer comprises the following steps: (a) preparing a fermentation medium, and crushing and mixing 85 to 95 weight percent of a carbon source, 1 to 2 weight percent of a nitrogen source, 1 to 3 weight percent of a growth promoter and the balance of water for later use; (b) inoculating candida utilis into the fermentation medium obtained in step (a), and performing solid fermentation cultivation; (c) inoculating lactobacillus plantarum into the fermentation medium obtained in step (b), performing anaerobic solid fermentation cultivation, and performing sampling for OD600 at a time interval of 4h; (d) when OD600 enters an exponential phase, inoculating bacillus subtilis into the fermentation medium obtained in step (c), and performing solid fermentation cultivation. The biological feeds prepared according to the method have the advantages that the microecological balance of rumens of ruminants can be improved, the feed conversion rate can be increased, the immunity of the organism can be improved, and the products have special sour and sweet smell and high palatability, and are easy for animals to ingest.

A method for increasing the systemic exposure of cells selected from tumor cells and normal cells to an orally administered pharmaceutically active compound, wherein a bioenhancer comprising an inhibitor of BCRP is orally administered concomitantly with said orally administered pharmaceutically active compound, and in which method the inhibitor is administered simultaneously with the pharmaceutical compound.

The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zinzeber officinale extract to improve the bioavailability of a wide variety of drugs.

The invention belongs to the technical field of materials, and provides a preparation method of a starch and low-polylactic acid graft copolymer. The preparation method of the starch and low-polylactic acid graft copolymer comprises the steps that a starch reaction product, a low-polylactic acid reaction product and poly-organic acid are put into a high mixing machine for uniform blending to obtain a first mixture; a graft monomer and an initiator are added into the first mixture, and reaction mixing is carried out under 100-200 DEG C to obtain a second mixture; and a biological lubricant anda biological reinforcing agent are added into the second mixture, homogeneous mixing is carried out and a mixture is added into a parallel same-phase twin-screw extruder for plasticizing granulation,and the starch and low-polylactic acid graft copolymer is obtained. On the one hand, graft copolymerization is carried out on modified starch and modified low-polylactic acid, compatibility is higher,hydrophilic groups of the modified starch and the modified low-polylactic acid are shielded mutually, a hydrophobic effect is achieved and the grafting efficiency is high, organic combination of thestarch and the low-polylactic acid is realized, and the advantages of the starch and the low-polylactic acid are fully played; and on the other hand, the degradation performance of the obtained starchand low-polylactic acid graft copolymer is excellent, and the cost is obviously lower than traditional polylactic acid.

The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

The present invention relates to a resin comprising a bio-enhancer and an optional therapeutically active ingredient or precursor thereof loaded thereon. The bio-enhancer is ionizable or non-ionizable, and the resin may be a cation exchange resin or an anion exchange resin.

The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of anti-infective. This may be useful to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease and to lower the concentration of antiinfectives necessary to inhibit the growth of microbial strains.

Herbal compositions are useful for inhibition, amelioration or prevention of adipogenesis mediated diseases such as obesity, lipid storage disease and hyperlipemia. The herbal compositions comprise biologically effective amounts of extracts or fractions from Piper betle in combination with one or more of the extracts or fractions derived from Dolichos biflorus, Commiphora mukul, Boerhaavia diffusa, Tribulus terrestris and Zingiber officinale as active ingredients. The compositions optionally contain a bio-enhancing agent or a bio-protecting agent, along with biologically acceptable carriers or diluents. The herbal compositions may be used in a method for treating or preventing adipogenesis involved diseases in mammals.

Herbal compositions are useful for inhibition, amelioration or prevention of adipogenesis mediated diseases such as obesity, lipid storage disease and hyperlipemia. The herbal compositions comprise biologically effective amounts of extracts or fractions from Piper betle in combination with one or more of the extracts or fractions derived from Dolichos biflorus, Commiphora mukul, Boerhaavia diffusa, Tribulus terrestris and Zingiber officinale as active ingredients. The compositions optionally contain a bio-enhancing agent or a bio-protecting agent, along with biologically acceptable carriers or diluents. The herbal compositions may be used in a method for treating or preventing adipogenesis involved diseases in mammals.

The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zinzeber officinale extract to improve the bioavailability of a wide variety of drugs.

The present invention relates to pharmaceutical composition with lysergol as bioactive enhancer and bioavailability facilitator for broad-spectrum antibiotics. The present invention has direct implication in reducing the dosage of antibiotics while increasing the efficiency of absorption of nutritional elements.

Embodiments of the invention are directed to compositions containing cannabinoids and bioenhancers for treating obesity, eating disorders, metabolic disorders, and other body weight related diseases and disorders, and methods for treating obesity, eating disorders, metabolic disorders, and other body weight related diseases and disorders by administering compositions containing cannabinoid and a bioenhancer.

The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zinzeber officinale extract to improve the bioavailability of a wide variety of drugs.

The invention relates to the technical field of aquaculture, and specifically relates to an aquaculture composite plant fermentation broth and a preparation method thereof. The fermentation broth adopts mulberry leaf, chrysanthemum stem and leaf, honeysuckle leaf and ginkgo leaf as main raw materials, and adopts molasses and crystal salt as auxiliary materials. After a period of time of pickling, the pickle liquid is adopted as a fermentation mother liquor; a culture solution prepared with molasses, crystal salt and sterile water is added; and secondary fermentation is carried out under a certain temperature for a certain period of time, such that the fermentation broth is obtained. The aquaculture composite plant fermentation broth is prepared from the raw materials of pure natural materials. The production cost is low, the raw material source is wide, and no other chemical additive is used. The fermentation broth is simple to use, and has a good effect. The fermentation broth causes no secondary pollution, and provides a bio-enhancer effect. With the fermentation broth, large amounts of ammonia nitrogen, phosphorus salt, sulfur, microbes, pathogens and the like can be removed, and a significant effect is provided for improving water quality and preventing water pollution.

The invention belongs to the field of environmental protection, and particularly relates to a natural composite plant treatment agent for domestic wastewater and a preparation method thereof. The natural composite plant treatment agent for the domestic wastewater takes wormwood, mulberry leaves, black tea, leaves of flos lonicerae and ginkgo leaves as the raw materials, curing liquid is obtained through a curing method, and the natural composite plant treatment agent is finally obtained by conducting secondary fermentation on the curing liquid. The treatment agent is prepared by adopting the purely natural materials as the raw materials, the sources of the raw materials are extensive, the production cost is low, other chemical additives do not exist, the function of a biological reinforcing agent can be achieved, the degradation of pollutants is obviously facilitated, secondary pollution to the environment does not exist, the treatment effect on the domestic wastewater is excellent, various indexes of the treated domestic wastewater can meet the first level (B) emission standard of Discharge Standard of Pollutants for Municipal Wastewater Treatment Plant (GB 18918-2002), and the natural composite plant treatment agent for the domestic wastewater has extensive promotion significance.

The present invention relates to synthetic capsaicin analogues, tautomers or salts thereof and their use as bioenhancers. The invention provides substituted capsaicyns for use as a bioenhancer, use as a bioenhancer on active substances, in compositions preferably for oral administration, such as in feed, food, pharmaceutical compositions or supplements.

The present disclosure provides a composition for enhancing effect of an inhibitor in inhibiting NAD+ / NADP+ or NADH / NADPH dependent enzymes. The inhibition of the NAD+ / NADP+ or NADH / NADPH dependent enzymes such as Enoyl-ACP reductase (ENR) by the composition of the present disclosure serves as a target for treating malaria and other infectious diseases. The present disclosure provides composition comprising inhibitor and polyphenol, wherein the polyphenol was found to enhance the inhibitory activity of the inhibitor. The present disclosure provides method for treating an infectious disease comprising administering an effective amount of the composition of the present disclosure to patients in need thereof. The present disclosure further provides a method for identifying a compound that enhances the effect of the inhibitor, a method of determining the antimalarial activity of a compound and use of polyphenol as a bioenhancer that enhances effect of an inhibitor for inhibiting NAD+ / NADP+ or NADH / NADPH dependent enzymes. The present disclosure provides a composition comprising inhibitor and a polyphenol wherein the polyphenol enhances effect of the inhibitor for inhibiting aldose reductase for treating complications of diabetes that include diabetic retinopathy, cataract neuropathy and neural complication.

The present invention relates to a bioadditive for heavy oils that serves to reduce polluting emissions and bio-enhancer of the combustion performance for heavy oils, which comprises methyl esters of raps oil, also called raps biodiesel, in the range of up to 80% v / v, surfactants in the range of up to 80% v / v, diluents in the range of up to 20% v / v and metal oxides between 0.1-5 g / L.

Disclosed are compounds for use in raising an immune response to an antigen and / or enhancing, modulating or augmenting an immune response to an antigen. Particularly the use of urolithins. The invention also relates to immune enhancers comprising urolithins, methods of using such immune enhancers and processes for the preparation of such immune enhancers. The invention also relates to the use of urolithins in methods for modulating stem cell function, for example, enhancing stem cell numbers, promoting stem cell regeneration and promoting stem cell differentiation.

A pharmaceutical formulation is provided comprising combination of anti-tuberculosis drug drugs optionally in combination of bioenhancers. The formulation is used for the treatment of diseases caused by mycobacterium tuberculosis. The process of preparation of the formulation is also provided.

The invention discloses biological fortifier for improving efficiency of degrading m-dichlorobenzene by microorganism in the liquid phase and an adding method thereof. The biological fortifier is prepared from rhamnolipid, FeCl3, MgCl2, MnSO4.H2O, ZnCl2, CuSO4.H2O, CoCl2.6H2O, Na2MoSO4.2H2O and AlCl3.6H2O. The method for improving efficiency of degrading m-dichlorobenzene by the biological fortifier in the liquid phase includes the following steps that 1, the average flow rate of the liquid phase in waste water or waste gas in biological equipment is calculated, and the biological agent is added according to the ratio of 0.1%; the biological agent is uniformly added into the waste water or gas microbiological treatment in a spraying mode. The provided biological fortifier is scientific and reasonable in component matching, capable of greatly improving the efficiency of degrading m-dichlorobenzene by microorganism, low in cost and high in operability, has a great significance in environment protection and has important application value.

A water-based, alcohol-free, skin and hard surfaces sanitizing solution with a natural skin softener, where the nature of the biocidal enhancer used in the process of making the solution significantly increases efficacy while simultaneously enabling much more economical manufacturing, processing and transportation of the product. As the present solution is water-based, no further moisturizing additives are required, and those with sensitive skin, diabetes, allergies or religious beliefs are able to use the product without concern.

The invention relates to a ruminant feed bioenhancer and a preparation method thereof, which comprises the following steps: a) preparing a fermentation medium, by weight: a carbon source of 85%-95%, a nitrogen source of 1%-2%, The growth promoter is 1%-3%, and the balance is water. The above-mentioned ingredients are crushed, mixed, and set aside; b) inoculating Candida utilis in the fermentation medium obtained in step a), and solid fermentation culture; c) in step a) b) Lactobacillus plantarum is inoculated in the obtained fermentation medium, and anaerobic solid fermentation is cultivated, and OD600 is detected by sampling every 4 hours; d) when OD600 enters the logarithmic growth phase, Bacillus subtilis is inoculated in the fermentation medium obtained in step c), and solid fermentation is carried out. nourish. The biological feed prepared by the method can improve the rumen micro-ecological balance of ruminants, improve feed conversion rate and body immunity, and the product has a special sour-sweet smell, good palatability, and easy for animals to eat.

The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zinzeber officinale extract to improve the bioavailability of a wide variety of drugs.