This application is the divisional application of an inventive
patent application with the application number of 201110004638.9, the application date of January 11th, 2011 and the name of compound
medicine composition for improving oral
bioavailability of
paclitaxel and the application of the compound
medicine composition. The invention discloses a compound
medicine composition for improving oral
bioavailability of
paclitaxel and the application of the composition. The invention further discloses a medicine composition comprising the compound medicine composition and
paclitaxel monomer compounds. The compound medicine composition provided by the invention can be used for improving the oral
bioavailability of the paclitaxel; and when being used for preparing anti-
cancer drugs, the compound medicine composition can improve the anti-
cancer effect of the paclitaxel. In the compound medicine composition provided by the invention, the paclitaxel is the main anti-
cancer ingredient; the
monomer compounds are extracted by
traditional Chinese medicine; the oral bioavailability and anti-cancer effect of the paclitaxel are improved by inhibiting the
first pass effect of the paclitaxel. Experimental investigation shows that the compound medicine composition provided by the invention is prepared into oral medicines so as to improve
blood concentration and anti-cancer effect of the paclitaxel after
oral administration.