The invention discloses a mixing and dust-sucking device for producing anti-radiation dry powder mortar. The mixing and dust-sucking device comprises blanking hoppers, an electromagnetic water valve, spacers, feeding control valves, combined raw material blanking chambers, mixing propeller sets I, mixing propeller sets II, a discharging control valve, a discharging hopper, a support frame, a rinsing tank, a primary mixing chamber, a mixing and stirring chamber, a lead ball coagulation chamber, a machine body, vibration chambers, coagulation chamber discharging openings, coagulation chamber bodies, dust sucking chambers, telescopic dust sucking hoses, a water inlet pipe, a water spraying nozzle, exhaust fan assemblies, lead ball seat plates, vibration modules, a water spraying device, dust sucking devices, mixing and stirring devices, hot air holes and an air heating machine. The present invention aims to provide a mixing and dust-sucking device for producing anti-radiation dry powder mortar; lead ball particles can be uniformly mixed with other raw materials; the device is high in production efficiency, convenient to discharge and low in abrasion on equipment; in addition, the device is capable of adsorbing dust in the raw materials on the surfaces of the lead ball particles; the dust reduction effect can be achieved; the pollution to the air can be reduced.