The invention discloses a fatigue driving preventing device. The fatigue driving preventing device comprises a fatigue predicting module, a face information identifying module, a face information judging module and an inner alarming module. When the anti-fatigue driving device is used, the fatigue predicting module can conduct active prediction on a driver at intervals, and sends out fatigue test signals if conditions are met; the face information identifying module collects face information parameters and conducts analysis and contrast on the face information parameters and preset fatigue parameters through the face information judging module; if alarm sending-out conditions are met, the inner alarming module sends out an alarm to the driver. The fatigue driving preventing device does not need to be hung on the driver, so that subjective rejecting emotions of the driver are avoided. Besides, the fatigue predicting module is arranged in advance, and whether the driver is fatigued or not can be tested irregularly in the whole driving process of the driver, so that leakage judgment is reduced. Moreover, a pre-judging module and the judging module are simultaneously arranged, so that double insurance is achieved, and the probability of misjudgment is reduced. Finally, irregular monitoring is adopted, fatigue monitoring is not continually conducted in the whole driving process, so that resources are greatly saved, and requirements for devices are lowered.