The invention provides a large-span prestressed box-shaped simply supported steel beam-column structure, which includes steel columns, simply supported steel beams, corbels, anchor plates, sleeves, and prestressed tendons, and the right flange of the left steel column is welded and fixed Corbel, the left end of the steel beam is fixed on the upper surface of the corbel by bolts, the right end of the steel beam is welded and fixed to the left flange of the right steel column; the left end of the steel beam is welded with a cover plate, and the lower part of the cover plate is welded with a lower positioning plate, the cover plate An upper positioning block is welded on the upper side, and the anchor plate is clamped between the lower positioning plate and the upper positioning block; the two ends of the prestressed tendons are anchored on the anchor plate and the left flange of the right steel column. The large-span prestressed box-shaped simply supported steel beam-column structure provided by the present invention has high rigidity and high elastic bearing capacity, can effectively reduce the mid-span deflection of the steel beam, reduce the section height of the steel beam, have high safety performance, simple structure, and low cost , good durability, small prestress loss, and may be widely used in long-span structures.