31results about How to "Realize trace detection" patented technology

The invention discloses a biological sensor, which comprises a sensor wafer, a measuring pad point, a differential inductance coil, an air bridge structure, a point array capacitor, a capacitor upper plate, and a capacitor lower plate. The preparation method is as follows: deposit the gallium nitride dielectric layer on the surface of the wafer; use Ti / Au as the first layer of seed metal; use photoresist to define the underlying metal, SiNx dielectric layer, air bridge column, and air bridge metal. structure, electroplating the lower metal and upper metal on the seed metal; depositing the gallium nitride passivation layer on the surface of the wafer; defining the structure of the contact electrode Pad; grinding, polishing, cutting, and metal jumper bonding, and packaging. The present invention forms a microwave resonator device through intertwining differential inductors and circular point array capacitors in series, which greatly reduces the chip size occupied by the device while improving the quality factor of the device; solves the problem of measuring biomarkers by microwave devices The problem of low sensitivity when the solution concentration is low.

The invention relates to a delta type resonant cavity / integrating sphere combination reinforcing cavity capable of improving the sensitivity of gas Raman detection. The delta type resonant cavity / integrating sphere combination reinforcing cavity comprises three endoscopes (M1, M2 and M3) with high reflectivity, a gold-plated integrating sphere, inverse reflecting mirror (M4) with high reflectivityand a sealing chamber, wherein the three endoscopes (M1, M2 and M3) with the high reflectivity are inlaid in three holes corresponding to the gold-plated integrating sphere, the inverse reflecting mirror (M4) with the high reflectivity is arranged outside the gold-plated integrating sphere and in rear of the endoscope (M3), and the inverse reflecting mirror (M4) is arranged in the sealing chamber. The delta type resonant cavity / integrating sphere combination reinforcing cavity capable of improving the sensitivity of the gas Raman detection has the advantages that for the problems that an existing detection device for characteristic gases in a change-over state is low in detection accuracy and cannot measure and distinguish multiple characteristic gases simultaneously, the technical bottleneck that the minimum gas detection concentration of a Raman spectrum cannot meet the requirements is broken through, and the accuracy and sensitivity of the detection of the characteristic gases in the change-over state are greatly improved.

The invention discloses a glucose quantitative testing sensor based on a microwave patch resonator and a preparation method. The sensor solves the problem that a glucose concentration is inaccurate when a microwave device measures the glucose concentration. The method comprises the following steps: firstly manufacturing the patch resonator and a sample patch of a coplanar waveguide feeder on the front side of a semi-conductive substrate, and then manufacturing a fence structure of SU-8 light resistance adhesive on the front side of the substrate containing the sample patch, or manufacturing a groove structure on the back side of the substrate containing the sample patch. The sensor adopts resonant frequency and reflection coefficient as detection parameters, realizes the characteristics that the detection reaction time is not more than one second, the sensitivity is high and the sensor can be reused, and overcomes the disadvantage that generally biosensors based on microwave devices cannot perform quantitative detection.

The present invention relates to a high-sensitivity biosensor and its manufacturing method and application. First, the nano-gold particles or pine-like gold are modified on the surface of the electrode by electroplating, and then the conductive polymer is modified on the surface of gold materials with different morphologies by electrochemical polymerization, by activating the carboxyl groups on the surface of the conductive polymer; finally The activated electrode is immersed in a specific bioidentifier, and the bioidentifier is immobilized through an amide reaction to obtain the high-sensitivity biosensor. Different biomarkers on highly sensitive biosensors can be used for the specific detection of different biomarkers. The invention uses pine tree-like gold or nano-gold and conductive polymers to prepare high-sensitivity biosensors, greatly increases its surface active area, promotes electron transfer, and enhances the electrical conductivity of electrodes; finally, the sensitivity of the biosensor is improved, and the biological marker is realized. Trace detection, the lowest detection limit reaches aM level (10 ‑9 nM).

The invention discloses a reduced glutathione fluorescent probe with pyrazoline as a maternal body. The probe is 2-(1, 5-diphenyl-4, 5-dihydro-1H-pyrazole-3-yl)phenyl acrylate. The probe provided by the invention can selectively interact with reduced glutathione, has a fluorescence enhancement effect, can be used for analysis through fluorophotometry and can realize trace detection of reduced glutathione. With high sensitivity, the reduced glutathione fluorescent probe is suitable for wide popularization.