The invention discloses a combined mold-core insert core full-automatic feeding, discharging and detachment mechanism in cooperation with an injection molding machine. The mechanism comprises the injection molding machine, a combined insert core assembly working station, a formed product discharging working station, a combined insert core feeding conveying device of a butt joint combined insert core assembly working station, a combined insert core detachment mechanism, a robot clamping mechanism, a sub insert core A return stroke conveying line conveyed to the combined insert core assembly working station, sub insert core B return stroke conveying lines of the butt joint combined insert core assembly working station and the formed product discharging working station and a sub insert core Bdischarging conveying line conveyed to the formed product discharging working station, wherein the robot clamping mechanism grabs a combined insert core from the combined insert core feeding conveying device to the interior of the injection molding machine and grabs the formed combined insert core from the injection molding machine to the combined insert core detachment mechanism. According to the combined mold-core insert core full-automatic feeding, discharging and detachment mechanism in cooperation with the injection molding machine, automatic feeding, discharging, detachment and circulation of a combined insert core in a secondary injection molding formation technology can be achieved, the production efficiency is greatly improved, and the safety of operators is improved.