The invention discloses a misgurnus anguillicaudatus red-fin disease prevention and treatment feed additive, which is prepared from the following raw materials: agrimonia pilosa ldb, artemisia anomala s. moore, fructus viticis, nidus vespae, periostracum cicadae, Xiangmo, faeces trogopterpri, myrrh, frankincense, semen persicae, lancea tibetica, adhatodavasicanees, halenia corniculata, adder tongue herb, ginkgo leaf, prunusmlzmesieb.etzucc, pine pollen, corn pollen, compound enzyme A, and compound enzyme B. According to the present invention, the misgurnus anguillicaudatus red-fin disease prevention and treatment feed additive has the rich aroma, and further has effects of misgurnus anguillicaudatus food intake increasing, growth and development promoting and resistance enhancing, wherein the incidence of the red-fin disease is reduced to 3-4%, the mortality rate is reduced to 0%, the disease treatment rate is 84%, and the income is increased by 17.8%; the pollens are added, such that the nutrition and the fragrance are enriched, the intestine and the stomach of the misgurnus anguillicaudatus are protected, and the wound healing is accelerated; and a variety of the traditional Chinese medicine extracts are added, such that the advantages of scientific compatibility, complement efficacy, antibacterial effect, anti-inflammation effect, no drug resistance generation, misgurnus anguillicaudatus immunity enhancing, no agent residue, delicious misgurnus anguillicaudatus meat taste, fishy smell reducing and health function increasing are provided, and the modern consumer demand is met.