The invention discloses grape and apple mixed ready-to-drink wine and a preparation process thereof. The grape and apple mixed ready-to-drink wine is prepared from 150 to 180 parts of grape wine, 15 to 18 parts of vodka, 35 to 45 parts of rum, 22 to 28 parts of gin, 90 to 120 parts of apple juice, 28 to 35 parts of lemon juice, 500 to 1000 parts of water, 30g / L to 40g / L of white granulated sugar and 0.1g / L to 0.3g / L of apple essence. The preparation process comprises the following steps: mixing the vodka, the rum and the gin according to a ratio to form base liquor; adding the freshly pressed apple juice, the grape wine, the apple essence, the freshly pressed lemon juice, the white granulated sugar and the water into the base liquor and uniformly mixing; clarifying, filtering, filling, sterilizing and packaging a mixed solution to prepare the grape and apple mixed ready-to-drink wine. The prepared ready-to-drink wine has a cherry-red color, is transparent and glossy, has grape and apple flavors and has proper sweetness and alcohol content. The styles and characteristics of the grape wine, the gin, the rum and the vodka are fused so that the styles and characteristics of the ready-to-drink wine are more prominent. The ready-to-drink wine adopts two types of flavor raw materials, namely grapes and apples, so that a product prepared by the process has the characteristic of high nutrient value and the taste of the ready-to-drink wine is more abundant, and furthermore, the market of the ready-to-drink wine is more diversified.