The invention relates to a novel high-speed blister packaging machine. The high-speed blister packaging machine comprises a rack which is sequentially provided with a blister support forming device, a forming traction device, a blister heat sealing device, a heat sealing traction device, a blister punching device and a blister grating conveying device, and is characterized in that a blister cooling device is arranged between the blister heat sealing device and the heat sealing traction device; the bubble cap cooling device comprises a cooling box and a cooling plate, the cooling plate is arranged in the cooling box, and a cooling channel for the bubble cap to pass through is arranged below the cooling plate. According to the high-speed blister packaging machine, the blisters subjected to heat sealing can be quickly cooled down, so that the blisters are prevented from being deformed in the blister traction process of the heat sealing traction device.