The invention discloses a CK46 inclined rail numerical control lathe of an integral casting lathe bed. The lathe bed, a drive shell, a transmission mechanism, a machine body shell, a protection mechanism and a control mechanism are included. The drive shell is fixedly arranged at one end of the top of the lathe bed. The position, located on one side of the drive shell, of the top of the lathe bedis fixedly provided with the transmission mechanism. The CK46 inclined rail numerical control lathe is compact in structure, simple and convenient to operate and high in practicability. A bridge typemain shaft is arranged, the 45-degree inclined lathe bed is adopted while 45 degrees are the rigidity and stress balance gold degree, so that stress calculation is simple, scrap discharging is convenient, and tool arranging is smooth; meanwhile, the X-axis stroke can reach one meter, the Z-axis stroke can reach 380 mm, a hiwin RGW35 roller guide rail is adopted in a transmission guide rail, a Yaskawa 7-series bus servo motor is matched, and the machining effect can be played perfectly in software and hardware configuration; and in addition, a resin sand integral casting base is adopted, compared with a traditional welding base, the anti-shock performance is improved, the machining rigidity is enhanced, and form and location tolerance is guaranteed to the maximum degree.