The invention relates to a cefminox sodium crystal as well as a preparation method thereof. The crystal is measured by using a powder X-ray diffraction measuring method, and an X-ray powder diffraction pattern indicated by an diffraction angle of 2 theta + / -0.2 degree shows a characteristic diffraction peak at 8.60 degrees, 9.00 degrees, 10.68 degrees, 12.58 degrees, 12.74 degrees, 13.70 degrees, 15.34 degrees, 15.60 degrees, 17.00 degrees, 18.00 degrees, 18.54 degrees, 19.18 degrees, 21.02 degrees, 21.52 degrees, 21.86 degrees, 22.70 degrees, 23.86 degrees, 24.24 degrees, 24.90 degrees, 25.18 degrees, 25.90 degrees, 26.54 degrees, 27.12 degrees, 27.54 degrees, 29.38 degrees, 30.62 degrees, 31.22 degrees, 32.24 degrees, 32.84 degrees, 34.30 degrees, 35.88 degrees, 36.32 degrees, 36.44 degrees, 36.54 degrees, 38.14 degrees, 39.10 degrees, 39.62 degrees, 40.32 degrees, 41.04 degrees, 41.78 degrees, 43.44 degrees, 43.70 degrees, 44.04 degrees, 45.02 degrees, 45.88 degrees, 47.64 degrees, 48.20 degrees, 48.80 degrees, 55.90 degrees and 57.64 degrees. The cefminox sodium crystal is a novel crystal, and has lowest amount of substance, highest effectiveness, best thermal stability, quickest red-dissolving velocity and highest safety among all crystals. The preparation method disclosed by the invention is simple and good in reproducibility, and has great practical value.