The invention discloses a high-reliability electric power cable. The high-reliability electric power cable comprises multiple conductors, a wrapping layer which is arranged on the exteriors of the conductors in a wrapping manner, an insulating layer which is arranged on the exterior of the wrapping layer in an extrusion manner, a shielding layer which is arranged on the exterior of the insulating layer in a wrapping manner, a waterproof layer which is arranged on the exterior of the shielding layer in a coating manner, a fireproof layer which is arranged on the exterior of the waterproof layer in a packaging manner, and an outer sheath which is arranged on the exterior of the fireproof layer in an extrusion manner. The high-reliability electric power cable provided by the invention has the characteristics of high temperature resistance, fireproof and flame-retardant property, waterproof and oil-resistant property, aging resistance, and long service life; meanwhile, the high-reliability electric power cable also has high physical and mechanical performance, tearing strength and processing property; the high-reliability electric power cable can be applied to occasions of high-rise buildings, airports, wharfs, underground railroads and the like for ensuring continuous operation of firefighting power utilization equipment and important equipment, such as a fire pump, a fire lift, partial lamination, emergency evacuation indication, security and monitoring, a smoke preventing and exhausting system, a self-contained power supply and the like in a fire situation; and in addition, the high-reliability electric power cable is applicable to water treatment equipment, such as a submerged pump, a coal mine, an underwater operation, a water landscape lamp and the like.