The invention discloses a construction method of a progressive
cerebral arterial thrombosis model. Progressive
cerebral arterial thrombosis is a special type of
stroke, and has the characteristics of continuous
exacerbation of
neurological dysfunction,
poor prognosis, lack of effective drugs, and very difficult
clinical treatment. Due to the lack of animal models capable of accurately simulating the
pathological process of progressive
stroke, the research on the
pathological mechanism of the
disease and the research and development of therapeutic drugs are greatly limited. According to the method, related experimental parameters of a photochemical
embolism method are improved, so that the cerebral
ischemia injury degree of animals accords with the
pathological characteristics of progressive
stroke, and the progressive cerebral
ischemic stroke model is successfully constructed. The method has the main beneficial effects that a new modeling method of the mouse progressive
cerebral arterial thrombosis model is provided, and the blank of progressive cerebral arterial
thrombosis animal models in academic circles is filled. Meanwhile, the operation is simple, convenient and feasible, the animal wound is small, the
repeatability is good, the process is close to the
pathogenesis process of human thrombotic cerebral apoplexy, and the method has important application value in the research of the pathological mechanism of the
disease and the research and development of new drugs and new targets.