The invention provides full water-based plastic flexible printing ink. The full water-based plastic flexible printing ink is prepared by the following raw materials by weight: 35-70 parts of printing ink connection materials, 25-50 parts of color paste, 1-10 parts of a flatting agent, 1-10 parts of a defoamer, 1-8 parts of wax emulsion, and 5-20 parts of deionized water. The color paste is prepared by mixing the following raw materials by weight: 20-55 parts of printing ink resin, 20-50 parts of organic pigments, 1-8 parts of a wetting dispersant, 1-6 parts of the defoamer, and 20-40 parts of the deionized water. The full water-based printing ink has abroad application range, and has environment-friendly feature compared with the normal water-based printing ink, and is capable of greatly reducing the pollutant residue and volatility gases on the surface of a printed matter, and realizing the zero release of VOC in the printing ink products. The full water-based printing ink has the characteristics of good adhesive force, rub resistance, scratch resistance, weather resistance, water resistance, chemical resistance, resistance and so on, and the high-speed flexible printing is more than 150 m / min.