35results about How to "Efficient localization" patented technology

A directional brain stimulation lead assembly provides a lead body and an insulating member defining one or more windows that selectively expose portions of electrodes carried by the lead body to produce a directional stimulation current field. The lead assembly can achieve more effective localization of electrical stimulation to very small brain targets, and thereby reduce the incidence of material side effects caused by collateral stimulation of brain tissue adjoining a desired brain target. In addition, the directional lead can sense brain activity on a more localized basis.

Electrocardiogram (ECG) recorded signals are processed by a computer-implemented method to substantially remove extraneous signals to produce intermediary signals, and to separate the intermediary signals using a non-orthogonal transformation method such as independent component analysis to produce independent components of signals. The separated signals are displayed to help physicians to analyze medical conditions and to identify locations of abnormal heart conditions.

Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.

The present invention relates to a method for detecting an analyte in a sample, said method comprising: (a) contacting said sample with at least one set of at least first and second proximity probes, wherein said probes each comprise an analyte-binding moiety and can simultaneously bind to the analyte, and wherein (i) said first proximity probe comprises a nucleic acid moiety attached at one end to the analyte-binding moiety, wherein a circular or circularizable oligonucleotide is hybridized to said nucleic acid moiety before, during or after said contacting step; and (ii) said second proximity probe comprises an enzyme moiety, attached to the analyte-binding moiety, capable of directly or indirectly enabling rolling circle amplification (RCA) of the circular or, when it is circularized, of the circularizable oligonucleotide hybridized to the nucleic acid moiety of the first proximity probe, wherein said RCA is primed by said nucleic acid moiety of said first proximity probe; (b) if necessary, circularizing said oligonucleotide, to produce a circularized template for RCA; (c) subjecting said circular or circularized template to RCA, wherein if the enzyme moiety of the second proximity probe in step (a)(ii) is a DNA polymerase, this step does not utilize a free DNA polymerase; and (d) detecting a product of said RCA.

Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.

The present invention features a solar-to-electric energy conversion device based on a light absorbing electrode coupled to a one-dimensional nanoparticle based photonic crystal. The function of the latter is to localize the incident light within the electrode thus enhancing the optical absorption and the power conversion efficiency of the so called dye-sensitized and organic (polymer based or hybrids) cell. The photonic crystal comprises alternating layers possessing different index of refraction and can be easily integrated into the cell.

The present invention concerns peptide sequences that specifically recognize cells of human hepatic metastases. The invention comprises also the use of nucleic acids coding for such peptides, as well as conjugates and formulations of such peptides for diagnostic and therapeutic purposes.

The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the local treatment of tumors, in particular glioblastoma.

The invention discloses a secure distributed database interaction method suitable for a mobile positioning system. The secure distributed database interaction method comprises seven modules, wherein arest data transceiving and attribution region division module is used for receiving client data and determining an attribution through an improved trie tree algorithm; a read-write separation local database module designs a statistical-based read-write separation algorithm to carry out read-write separation and temporary table establishment; a local key agreement module is used for designing a key agreement protocol on the basis of the pre-shared key and generating a session key; an attribution secret key negotiation module interacts with the local secret key negotiation module to generate asession secret key each time; a local data encryption and decryption and integrity protection module is responsible for encryption and decryption of local interaction data through an improved SM4 encryption algorithm; an attribution data encryption and decryption and integrity protection module is used for realizing encryption and decryption of attribution interaction data by designing and improving an SM4 encryption algorithm; and a read-write separation attribution database module is used for realizing read-write of the attribution database based on a statistical read-write separation algorithm.

A method is described for localizing a motor vehicle, comprising the following steps:transmitting via a wireless communication network configured within a parking lot, for a predetermined motor vehicle, a request that the predetermined motor vehicle carry out a predetermined action;after transmission of the request, checking whether a motor vehicle located within the parking lot is carrying out or has carried out the predetermined action;if the result of the check is that a motor vehicle located within the parking lot is carrying out or has carried out the predetermined action, authenticating the motor vehicle as the predetermined motor vehicle and localizing the predetermined motor vehicle at a current position of the motor vehicle.Also described are an apparatus for localizing a motor vehicle, a parking lot for motor vehicles, and a computer program.

The present disclosure provides a two-dimensional material detector with an asymmetrically integrated optical microstrip antenna, structurally including a metal reflecting surface, a dielectric spacer layer, a two-dimensional active material layer, a top source electrode, and a drain electrode integrated with a metal strip array. Self-driven photoresponse of a metal / two-dimensional material / metal structure is induced by a Schottky junction formed due to contact between the two-dimensional material and the metal. The asymmetrically integrated optical microstrip antennas break the symmetry between the two contact / two-dimensional material junctions. Light absorption in the contact / two-dimensional material junction integrated with optical patch antennas is significantly enhanced by efficient light in-coupling and intensified light localization; meanwhile, the extended boundary of the contact / two-dimensional material junction enlarges the photocurrent collection area. The light absorption in the other contact / two-dimensional material junction is significantly inhibited by a metal bottom surface which is very close to the two-dimensional material.

Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.

An improved magnetically-confined anode plasma pulsed ion beam source. Beam rotation effects and power efficiency are improved by a magnetic design which places the separatrix between the fast field flux structure and the slow field structure near the anode of the ion beam source, by a gas port design which localizes the gas delivery into the gap between the fast coil and the anode, by a pre-ionizer ringing circuit connected to the fast coil, and by a bias field means which optimally adjusts the plasma formation position in the ion beam source.

Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

A method, a system and a computer readable medium for automatic segmentation of a 3D medical image, the 3D medical image comprising an object to be segmented, the method characterized by comprising: carrying out, by using a machine learning model, in at least two of a first, a second and a third orthogonal orientation, 2D segmentations for the object in slices of the 3D medical image to derive 2D segmentation data; determining a location of a bounding box (10) within the 3D medical image based on the 2D segmentation data, the bounding box (10) having predetermined dimensions; and carrying out a 3D segmentation for the object in the part of the 3D medical image corresponding to the bounding box (10).

Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

An image forming apparatus includes an image bearing member, a developing device, and an intermediate transfer member. The developing device includes a toner container containing a toner. The intermediate transfer member is charged to 3.0 nC / g or less in terms of absolute value at the surface thereof. The toner particles include a surface layer, and the brightness histogram of the toner particles has two local maximums P1 and P2 and a local minimum between P1 and P2. P2 is derived from the organosilicon polymer. P1 lies in a brightness range of 20 to 70, and P2 lies in a brightness range of 130 to 230. The number of pixels of P1 and the number of pixels of P2 are each 0.50% or more relative to the total number of pixels. The total numbers of pixels A1, AV, and A2 each in a specific brightness range satisfy specific relationships.

A biocompatible, resorbable collagen membrane containment member for a bone regenerative material, and a method of using such a containment member to regenerate a bone defect by surgically accessing the bone defect; disposing the containment member adjacent the bone defect, and thereafter injecting a bone regenerative material into the containment member.

A method for coding at least one holographic pattern recording a light signal representative of light received by a perspective object in a scene. The method includes: determining, from the light signal and for each point xj(1≦j≦M) of the holographic pattern, a set of N light rays passing through the point and corresponding respectively to N different viewing positions for viewing the pattern; generating from the M sets of N determined light rays, a plurality N of two-dimensional views of the object corresponding respectively to the N viewing positions of the pattern, by causing M determined rays to intersect at each of the viewing positions that are contained in a viewing plane parallel to a plane containing the holographic pattern; arranging the N generated views as a multi-view image of the object, the N views corresponding respectively to sub-images of the multi-view image; and compressing the multi-view image.

The invention relates to a nanoparticle preparation comprising nanoparticles of well-defined and reproducible sizes, that are substantially free of aggregate formation.